Listar por autor "Pérez-Martín, Margarita"
Mostrando ítems 1-20 de 20
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro
; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes, Manuel; Pérez-Martín, Margarita; Grondona, Jesús M; Rodriguez-de-Fonseca, Fernando; López-Ávalos, María Dolores[et al.] (2014-07-14)
Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, Maria Estela; García-Fernández, Maria Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, Maria Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Acute psychological stress: effects on hippocampal neurogenesis and the role of microglia
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Tabbai, Sara; Muñoz-Martin, José; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen[et al.] (2022)
Among all the factors that can contribute to the onset of psychopathological disorders, stress is the main environmental factor. The hippocampus is one of the most sensitive regions to the harmful effects of stress, in ... -
Determinación de las especies de LPA en hipocampo de ratón. Efecto de diferentes protocolos de estrés
(UMA Editorial, 2020)El LPA es un lípido bioactivo que está involucrado en la señalización intracelular a través de los seis receptores acoplados a proteínas G (LPA1-6). Entre estos receptores, LPA1 es un fuerte candidato para mediar los efectos ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Santin-Nuñez, Luis Javier; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen (ELSEVIER, 2021-11)
Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
Efectos del estrés sobre comportamientos de tipo depresivo, la microglía y la neurogénesis hipocampal. Papel del sistema LPA endógeno
(UMA Editorial, 2022)El estrés constituye el principal factor ambiental en la etiología de los trastornos psicopatológicos, entre ellos la depresión. El hipocampo es una de las regiones más sensibles a los efectos nocivos del estrés, pudiendo ... -
Effects of chronic stress on hippocampal microglia and neurogenesis of mice under social defeat stress.
Muñoz-Martín, José; Infantes-López, M. Inmaculada; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Pedraza-Benítez, Maria del Carmen; Pérez-Martín, Margarita[et al.] (2022-07)
Introduction: Chronic stress is the main environmental factor in the aetiology of depression and it is known that this type of stress may cause alterations in brain regions such as the hippocampus. Nevertheless, changes ... -
Effects on the hippocampal microglia after acute treatment of a psychological stressor associated with depressive-like behaviours
Nieto-Quero, Andrea; Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen[et al.] (2021-07)
Stressful life events may have a negative impact on mental health compromising people's well-being, so knowing the neurobiological changes that occur after psychosocial stressors can have an impact on overall health. ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes, Manuel; Grondona, Jesús M; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)
Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes, Manuel; Pérez-Martín, Margarita; Gavito, A.L.; García-Fernández, Maria Inmaculada; Estivill-Torrús, G.; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, Maria del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ... -
Microglial and neurogenic alterations in hypothalamus due to acute stress
Infantes-López, M. Inmaculada; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Tabbai-Amal, Sara; Pedraza-Benítez, Maria del Carmen; Pérez-Martín, Margarita[et al.] (2021-07)
Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous ... -
Propuesta de evaluación del Trabajo Fin de Grado de Biología basada en competencias
Altamirano-Jeschke, Maria; Rubio-Valverde, Lourdes; Muñoz-Gallego, Antonio Roman; Figueirido, Borja; Pérez-Martín, Margarita; Sanchez-Romero, Carolina; Trigo-Perez, Maria del Mar; Blanco-Lopez, Angel[et al.] (2014-07-01)
La formación del profesorado para las tareas de evaluación y tutorización de los Trabajos Fin de Grado (TFG) constituye uno de los factores importantes a tener en cuenta para su exitosa implantación. Así, el objetivo de ... -
Role of the LPA1 receptor in mood and emotional regulation
Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, Maria Estela; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2015-09-16)
Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ... -
Social avoidance and altered stress axis in a mouse model of anxious depression
Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Cifuentes, Manuel; García-Fernández, Maria Inmaculada; Chun, Jerold; Estivill Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-17)
Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ... -
Social defeat stress induces microglial alterations and impaired cell survival in the hypothalamus according to behavioral phenotype
Infantes-López, M. Inmaculada; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Muñoz-Martín, José; Pedraza-Benítez, Maria del Carmen; Pérez-Martín, Margarita[et al.] (2022-07)
Stress is the main environmental cause for depression, known to cause brain immune alterations. As major brain immune cells, microglia undergo transcriptional and, consequently, morphological changes that result in ... -
Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach
Moreno-Fernández, Román; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, Maria Inmaculada; Chun, Jerold; Pedraza-Benítez, Maria del Carmen; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier[et al.] (2018-07-16)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ... -
Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment
Moreno-Fernández, Román; Bacq, Alexandre; Rosell-del-Valle, Cristina; Zanoletti, Olivia; Cifuentes, Manuel; Pérez-Martín, Margarita; García-Fernández, Maria Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, Maria del Carmen[et al.] (2019-06-25)
The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ... -
The ependymal detach due to neuraminidase provokes hydrocephalus
Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Grondona, Jesús M; Cifuentes, Manuel; Pérez-Martín, Margarita; Fernández-Llebrez, Pedro[et al.] (2015-05-27)
Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ... -
The limbic brain under stress: a role for the LPA1 receptor
Moreno-Fernández, Román D.; Tabbai, S.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, Maria Estela; García-Fernández, Maria Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (UNED, 2017-07)
Adverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing ...