• A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase 

      Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes, Manuel; Pérez-Martín, Margarita; [et al.] (2014-07-14)
      Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ...
    • Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test 

      Moreno-Fernández, Román D.; Gomez-Salas, Francisco J.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2016-07-20)
      Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ...
    • The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression 

      Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2018-07-18)
      LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ...
    • IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall 

      Pérez-Martín, Margarita; Cifuentes, Manuel; Grondona JM; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)
      Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ...
    • Propuesta de evaluación del Trabajo Fin de Grado de Biología basada en competencias 

      Altamirano-Jeschke, Maria; Rubio, Lourdes; Muñoz-Gallego, Antonio Román; Figueirido, Borja; Pérez-Martín, Margarita; [et al.] (2014-07-01)
      La formación del profesorado para las tareas de evaluación y tutorización de los Trabajos Fin de Grado (TFG) constituye uno de los factores importantes a tener en cuenta para su exitosa implantación. Así, el objetivo de ...
    • Role of the LPA1 receptor in mood and emotional regulation 

      Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; Chun, Jerold; [et al.] (2015-09-16)
      Depression is a debilitating psychiatric condition characterized by anhedonia and behavioural despair among others symptoms. Despite the high prevalence and devastating impact of depression, underlying neurobiological ...
    • Social avoidance and altered stress axis in a mouse model of anxious depression 

      Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; [et al.] (2018-07-17)
      Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ...
    • Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach 

      Moreno-Fernández, Román; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, María; [et al.] (2018-07-16)
      LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ...
    • Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment 

      Moreno-Fernández, Román; Bacq, Alexandre; Rosell-Valle, Crisitina; Zanoletti, Olivia; Cifuentes, Manuel; [et al.] (2019-06-25)
      The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ...
    • The ependymal detach due to neuraminidase provokes hydrocephalus 

      Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Grondona, Jesús M; [et al.] (2015-05-27)
      Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ...
    • The limbic brain under stress: a role for the LPA1 receptor 

      Moreno-Fernández, Román D.; Tabbai, S.; Gómez-Salas, Francisco J.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; [et al.] (UNED, 2017-07)
      Adverse events can impact brain structure and function and are considered primary sources of risk for depression, anxiety, and other psychiatric disorders. In this sense, the neurobiological circuitry in charge of dealing ...