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Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernandez, Maria; Lucena-Serrano, Cristina; Rivera-Ramirez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
Differential effect of c-Fos activation associated with JNJ16259685 after an agonistic encounter as compared with grouped mice
Castro, Vanessa de; Suárez, Diana; Rivera-Ramirez, Alicia; Martín, Mercedes; Navarro-Humanes, Jose Francisco (European Neuropsychopharmacology 23, SUPPL. 2, S251, 2013-10)Glutamate is the major excitatory neurotransmitter in the brain, with widespread projections and localization of its various receptors. In a recent study, Navarro et al. [1] demonstrated that JNJ16259685 (a selective ... -
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramirez, Alicia; Suárez-Boomgaard, Diana; Gago, Belén; Valderrama-Carvajal, Alejandra; Medina-Luque, José; [et al.] (2013)Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
Dopamine D4 receptor counteracts morphine-induced changes in M opioid receptor signaling in the striosomes of the rat caudate putamen.
Rivera-Ramirez, Alicia; Valderrama-Carvajal, Alejandra; Roales-Buján, Ruth; Suárez-Boomgaard, Diana; Medina-Luque, José; [et al.] (2015-10-05)Morphine is one of the most potent analgesic drugs used to relieve moderate to severe pain. After long-term use of morphine, neuroadaptive changes in the brain promotes tolerance, which result in a reduced sensitivity to ... -
Dopamine D4R restores morphine-induced impairment of adult neurogenesis in the subventricular zone
Gago, Belén; Real-Aviles, Maria Angeles; Ponce-Velasco, Marina; Rivera-Ramirez, Alicia (2021)In the adult mammalian brain, neuroblasts from the subventricular zone (SVZ) migrate along the rostral migratory stream into the olfactory bulb, where they differentiate and synaptically integrate to contribute with the ... -
Estudio de la modulación del receptor µ opioide por el receptor dopaminérgico D4. Implicación en la adicción a morfina
Valderrama-Carvajal, Alejandra (Servicio de Publicaciones y Divulgación Científica, 2014)La morfina se utiliza en el ámbito clínico por ser un potente analgésico, sin embargo produce efectos adversos como la adicción. La administración de morfina induce una liberación masiva de dopamina en el estriado, produciendo ... -
Implicación del receptor dopaminérgico D4 en la adicción a morfina
Shumilov Bartenev, Kirill (UMA Editorial, 2020-09-30)La adicción es un trastorno asociado a un comportamiento compulsivo de consumo de drogas, en el que se produce una activación de las vías dopaminérgicas. El consumo prolongado desencadena un proceso de neuroadaptación. La ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros Gil, Silvia; Cabrera, Pablo; Valverde, Nadia; Romero-Zerbo, Silvana Y.; Lara, Estrella; [et al.] (2022-07-12)Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
Interacción de los receptores dopaminérgicos D4 y opioides tipo [micra] en el estriado: implicación en la fase inicial del consumo de morfina
Gago, Belén (Universidad de Málaga, Servicio de Publicaciones, 2007) -
On the balance of D2R-MOR and D4R-MOR in the dorsal and ventral striatum. Putative link to morphine dependence and addiction
Fores-Pons, Ramon; Narváez, Manuel; Vasudevan, Lakshmi; Crespo-Ramirez, Minerva; Rivera-Ramirez, Alicia; [et al.] (8th Mediterranean Neuroscience Society (MNS), 2022-05-30)The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was ... -
Role of dopamine D4 receptor in the development of morphine-induced analgesic tolerance
Ponce-Velasco, Marina; Rivera-Ramirez, Alicia; Gago, Belén; Real-Aviles, Maria Angeles (2021)Morphine is one of the most effective analgesic used in the clinical management of pain. However, long-term use of morphine can cause many side effects including respiratory depression, constipation, analgesic tolerance, ... -
Role of dopamine D4 receptor in the develpment of morphine-induced analgesic tolerance
Ponce-Velasco, Marina; Real-Aviles, Maria Angeles; Gago, Belén; Rivera-Ramirez, Alicia (Federation of European Neuroscience, 2022-07-10)Morphine is one of the most effective drugs used for pain management. However, prolonged exposition to morphine produces a wide variety of side effects such as tolerance to analgesia, hyperalgesia and addiction. Downregulation ...