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Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernandez, Maria; Lucena-Serrano, Cristina; Rivera-Ramirez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; [et al.] (2016-10-14)The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
Differential effect of c-Fos activation associated with JNJ16259685 after an agonistic encounter as compared with grouped mice
Castro, Vanessa de; Suárez, Diana; Rivera-Ramirez, Alicia; Martín, Mercedes; Navarro-Humanes, Jose Francisco (European Neuropsychopharmacology 23, SUPPL. 2, S251, 2013-10)Glutamate is the major excitatory neurotransmitter in the brain, with widespread projections and localization of its various receptors. In a recent study, Navarro et al. [1] demonstrated that JNJ16259685 (a selective ... -
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramirez, Alicia; Suárez-Boomgaard, Diana; Gago, Belén; Valderrama-Carvajal, Alejandra; Medina-Luque, José; [et al.] (2013)Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
Dopamine D4 receptor counteracts morphine-induced changes in M opioid receptor signaling in the striosomes of the rat caudate putamen.
Rivera-Ramirez, Alicia; Valderrama-Carvajal, Alejandra; Roales-Buján, Ruth; Suárez-Boomgaard, Diana; Medina-Luque, José; [et al.] (2015-10-05)Morphine is one of the most potent analgesic drugs used to relieve moderate to severe pain. After long-term use of morphine, neuroadaptive changes in the brain promotes tolerance, which result in a reduced sensitivity to ... -
Estudio de la modulación del receptor µ opioide por el receptor dopaminérgico D4. Implicación en la adicción a morfina
Valderrama-Carvajal, Alejandra (Servicio de Publicaciones y Divulgación Científica, 2014)La morfina se utiliza en el ámbito clínico por ser un potente analgésico, sin embargo produce efectos adversos como la adicción. La administración de morfina induce una liberación masiva de dopamina en el estriado, produciendo ... -
Implicación del receptor dopaminérgico D4 en la adicción a morfina
Shumilov Bartenev, Kirill (UMA Editorial, 2020-09-30)La adicción es un trastorno asociado a un comportamiento compulsivo de consumo de drogas, en el que se produce una activación de las vías dopaminérgicas. El consumo prolongado desencadena un proceso de neuroadaptación. La ... -
Interacción de los receptores dopaminérgicos D4 y opioides tipo [micra] en el estriado: implicación en la fase inicial del consumo de morfina
Gago, Belén (Universidad de Málaga, Servicio de Publicaciones, 2007)