Listar por autor "Rodriguez-de-Fonseca, Fernando"
Mostrando ítems 1-14 de 14
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Absence of LPA1 signaling results in defective cortical development
Estivill-Torrús, Guillermo; Llebrez Zayas, Pedro; Matas-Rico, Elisa; Rodríguez de Fonseca, Fernando; Chun, Jerold; Santín-Núñez, Luis Javier
; Pedraza-Benítez, María del Carmen; De-Diego-Barbado, Isabel; Del Arco-Herrera, Ignacio; Fernández-Llebrez, Pedro[et al.] (Oxford academy, 2008-04)
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing ... -
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits
Santín-Núñez, Luis Javier; Bilbao, Ainhoa; Pedraza-Benítez, María del Carmen; Matas-Rico, Elisa; López-Barroso, Diana; Castilla-Ortega, María Estela; Sánchez-López, Jorge; Riquelme, Raquel; Varela Nieto, Isabel; de la Villa, P.; Surdiaz, Margarita; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Wiley, 2009-11)
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA1 receptor in the regulation of plasticity and neurogenesis in the ... -
Cannabidiol administration during pregnancy and lactation modulates the suppressive effect of maternal alcohol exposure on cell proliferation and survival in the hippocampus of offspring
Rodríguez-Pozo, Miguel; Rubio-Rodríguez, Pablo; Rodríguez de Fonseca, Fernando; Suárez-Pérez, Juan; Rivera, Patricia (2024-11-28)
Excessive alcohol consumption during pregnancy causes neurodevelopmental disorders due to vulnerability and neuroadaptation of the immature brain with serious consequences on cognition. Since the endocannabinoid system ... -
Cocaine-conditioned place preference is predicted by previous anxiety-like behavior and is related to an increased number of neurons in the basolateral amygdala
(Elsevier, 2016-02-01)The identification of behavioral traits that could predict an individual's susceptibility to engage in cocaine addiction is relevant for understanding and preventing this disorder, but investigations of cocaine addicts ... -
Dataset for: "Cocaine-conditioned place preference is predicted by previous anxiety-like behavior and is related to an increased number of neurons in the basolateral amygdala."
Ladrón de Guevara-Miranda, David; Pavón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; Suárez, Juan; Rodríguez de Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Universidad de Málaga, 2024-01-24)
The identification of behavioral traits that could predict an individual's susceptibility to engage in cocaine addiction is relevant for understanding and preventing this disorder, but investigations of cocaine addicts ... -
Dataset for: "Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory"
Ladrón de Guevara-Miranda, David; Moreno Fernandez, Roman Dario; Gil Rodríguez, Sara; Rosell-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Universidad de Málaga, 2024-01-24)
Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
Evaluación del efecto terapéutico del d-pinitol como modificador multifacético en el curso de la enfermedad de alzheimer.
(UMA Editorial, 2024)La presente tesis doctoral aborda el potencial terapéutico del nutracéutico D-Pinitol (Caromax®-D-Pinitol (DPIN)) en el contexto de la enfermedad de Alzheimer (EA), centrándose en la atenuación de la resistencia a la ... -
Evaluación farmacológica del D-Pinitol como modulador de la insulina: Desarrollo de un nuevo concepto de edulcorante funcional.
(UMA Editorial, 2025)La diabetes mellitus es una enfermedad crónica debida, principalmente, a una incapacidad del páncreas para generar insulina y/o a que el organismo no puede utilizarla adecuadamente. La diabetes produce trastornos heterogéneos ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
Castilla-Ortega, María Estela; Sánchez-López, Jorge; Hoyo-Becerra, Carolina; Matas-Rico, Elisa; Zambrana-Infantes, Emma; Chun, Jerold; Rodríguez de Fonseca, Fernando; Pedraza-Benítez, María del Carmen; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (Elsevier, 2010-07)
Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
Rosell-Valle, Cristina; Martínez-Losa, Magdalena; Matas-Rico, Elisa; Castilla-Ortega, María Estela; Zambrana-Infantes, Emma; Gómez-Conde, Ana Isabel; Sánchez-Salido, Lourdes; Ladrón de Guevara-Miranda, David; Pedraza-Benítez, María del Carmen; Serrano-Castro, Pedro Jesús; Chun, Jerold; Rodríguez de Fonseca, Fernando; Álvarez Dolado, Manuel; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2021-04-01)
Defects in GABAergic function can cause anxiety- and depression-like behaviors among other neuropsychiatric disorders. Therapeutic strategies using the transplantation of GABAergic interneuron progenitors derived from the ... -
Sex-based differences in growth-related IGF1 signaling in response to PAPP-A2 deficiency: comparative effects of rhGH, rhIGF1 and rhPAPP-A2 treatments
Fernández-Arjona, María del Mar; Navarro, Juan Antonio; López-Gambero, Antonio J.; De Ceglia, Marialuisa; Rodríguez, Miguel; Rubio-Lamia, Leticia Olga; Rodríguez de Fonseca, Fernando; Barrios, Vicente; Chowen, Julie A.; Argente, Jesús; Rivera, Patricia; Suárez-Pérez, Juan[et al.] (BMC Springer Nature, 2024-04-08)
Understanding the physiological role of pregnancy-associated plasma protein-A2 (PAPP-A2), a proteinase involved in the insulin-like growth factor-1 (IGF1) availability to regulate growth, could provide insight into new ... -
Sex-specific alterations in emotional behavior and neurotransmitter systems in LPA1 receptor-deficient mice
Sánchez-Marín, Laura; Jiménez-Castilla, Violeta; Flores-López, María; Navarro Galera, Juan Antonio; Gavito, Ana Luisa; Blanco-Calvo, Eduardo; Santín-Núñez, Luis Javier; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Serrano, Antonia[et al.] (Elsevier, 2025-01-24)
Lysophosphatidic acid (LPA) and the endocannabinoid system (ECS) are critical lipid signaling pathways involved in emotional regulation and behavior. Despite their interconnected roles and shared metabolic pathways, the ... -
Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior
Sánchez-Marín, Laura; Ladrón de Guevara-Miranda, David; Mañas-Padilla, María del Carmen; Alén, Francisco; Moreno-Fernández, Román D.; Díaz-Navarro, Caridad; Pérez-del Palacio, José; García-Fernández, María Inmaculada; Pedraza-Benítez, María del Carmen; Pavón, Francisco Javier; Rodríguez de Fonseca, Fernando; Santín-Núñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, María Estela[et al.] (Elsevier, 2018-05-01)
The systemic administration of lysophosphatidic acid (LPA) LPA1/3 receptor antagonists is a promising clinical tool for cancer, sclerosis and fibrosis-related diseases. Since LPA1 receptor-null mice engage in increased ... -
The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder
(Elsevier, 2017-10-01)After discovering that addictive drugs alter adult neurogenesis, the potential role of adult-born hippocampal neurons in drug addiction has become a promising research field, in which cocaine is the most frequently ...