Listar por autor "Becerra-Ratia, José"
Mostrando ítems 1-20 de 42
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3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep
Crovace, Alberto Maria; Lacitignola, Luca; Monopoli Forleo, Donato; Staffieri, Francesco; Francioso, Edda; Di Meo, Antonio; Becerra-Ratia, José
; Crovace, Antonio; Santos-Ruiz, Leonor[et al.] (MDPI, 2020-08-11)
The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose ... -
A collagen-targeted biomimetic RGD peptide to promote osteogenesis
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Becerra-Ratia, José; Cifuentes-Rueda, Manuel[et al.] (MARY ANN LIEBERT, INC, 2014-01)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of ... -
A model of maxilla resection to test new hybrid implants:macroporous titanium and tissue engineering elements
Santos-Ruiz, Leonor; Monopoli, Donato; Yáñez Vilas, José Ignacio; Mentado, Belinda; Ruiz, F; Argárate, N; Granados, F; Arrabal-García, Pilar María; Belmonte, Rosa María; Becerra-Ratia, José[et al.] (2015-07-23)
Maxillary bone loss in commonly found in humans, due to bone ageing, tooth loos, periodontal disease and, more severely, to trauma, radiotherapy and tumor resection. Masillofacial reconstructive surgery is a still unmet ... -
A Novel Human TGF-β1 Fusion Protein in Combination with rhBMP-2 Increases Chondro-Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Claros-Gil, Silvia; Rico-Llanos, Gustavo Adolfo; Becerra-Ratia, José; Andrades-Gómez, José Antonio (MDPI, 2014)
Transforming growth factor-beta (TGF-β) is involved in processes related to the differentiation and maturation of osteoprogenitor cells into osteoblasts. Rat bone marrow (BM) cells were cultured in a collagen-gel containing ... -
A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (2013-11-27)
RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
Autologous Human-Derived Bone Marrow Cells Exposed to a Novel TGF-β1 Fusion Protein for the Treatment of Critically Sized Tibial Defect.
Becerra-Ratia, José; Guerado-Parra, Enrique; Claros-Gil, Silvia; Alonso, Mónica; Bertrand, María L; González Plata, Carlos; Andrades-Gómez, José Antonio[et al.] (Taylor & Francis, 2006)
We report the first clinical case of transplantation of autologous bone marrow-derived cells in vitro exposed to a novel recombinant human transforming growth factor (rhTGF)-β1 fusion protein bearing a collagen-binding ... -
Basic fibroblast growth factor enhances the osteogenic differentiation induced by bone morphogenetic protein-6 in vitro and in vivo
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (ELSEVIER, 2012-04)
Some members of the bone morphogenetic protein subfamily (BMP-2 and -7) are currently used in orthopedic surgery for several applications. Although their use is considered safe at short term, the high doses of growth factors ... -
Behavior of osteoprogenitor cells on EBM-sintered Ti6Al4V-scaffolds coated RGD-presenting hemidendrons. Implications for prosthesis design
González, Ana; Cabeza, Noemí; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Santos-Ruiz, Leonor; Becerra-Ratia, José; Monopoli, Donato[et al.] (2017-12-12)
Titanium-based prosthetic implants are commonly used in Traumatology and Maxillofacial Surgery to achieve functional recovery of a severely damaged bones. Prosthetic replacements fail in the long term due to poor ... -
Bone marrow mesenchymal stem cells, collagen scaffold and BMP-2 for rat spinal fusio
Arrabal-García, Pilar María; Visser, Rick; Cifuentes-Rueda, Manuel; Becerra-Ratia, José; Jiménez-Enjuto, E. (2013-11-08)
The use of autograft for posterolateral spinal fusion, continue being considered the gold standard for the treatment of spine pathologies. However, due to complications such as donor site morbidity, increased operating ... -
Characterization of adult stem/progenitor cell populations from bone marrow in a three-dimensional collagen gel culture system.
Claros-Gil, Silvia; Rodríguez-Losada, Noela; Cruz, Encarnación; Guerado-Parra, Enrique; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (Sage Publications, 2012-09-01)
Stem cell transplantation therapy using mesenchymal stem cells (MSCs) is considered a useful strategy. Although MSCs are commonly isolated by exploiting their plastic adherence, several studies have suggested that there ... -
Combining tissue engineering with metal scaffolds in orthopaedic to improve osseointegration of endoprothesis
Electron Beam Melting (EBM) technology allows the fabrication of free-formed metal scaffolds, thus creating the possibility of manufacturing patient-specific endo-prostheses. It also allows the production of highly-porous ... -
Comparative analysis and characterization of soluble factors and exosomes from cultured adipose tissue and bone marrow mesenchymal stem cells in canine species
Villatoro, Antonio J; Alcoholado Cueto, Cristina; Martín Astorga, María del Carmen; Fernández, V.; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (Elsevier, 2019-02)
The two main sources of mesenchymal stem cell (MSCs) in the canine species are bone marrow (cBM-MSCs) and adipose tissue (cAd-MSCs). The secretion of multitude bioactive molecules, included under the concept of secretome ... -
Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.
Vida-Pol, Yolanda; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio; Pérez-Inestrosa, Ezequiel[et al.] (Royal Society of Chemistry, 2016-05-17)
Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
Molina, Noemí; González, Ana; Monopoli, Donato; Mentado, Belinda; Becerra-Ratia, José; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel[et al.] (MDPI, 2020-04-01)
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
Desarrollo de prototipos de soportes tridimensionales a base de colágeno tipo I e hidroxiapatita para regeneración ósea
(UMA Editorial, 2022)El hueso es uno de los tejidos de mayor demanda para trasplante a nivel mundial, representando cerca de 2,2 millones de injertos anualmente. Por medio de la ingeniería de tejidos ósea (BTE) se han desarrollado estrategias ... -
Diseño de nuevas estrategias moleculares para la funcionalización de colágeno tipo I en ingeniería tisular ósea
(UMA Editorial, 2018)El colágeno tipo I, funcionalizado con proteína morfogenética de hueso 2 (BMP-2), es un biomaterial ampliamente utilizado en ingeniería tisular y cirugía ortopédica como alternativa al implante de hueso autólogo en los ... -
En memoria de Cajal
Becerra-Ratia, José (Universidad de Málaga, 2006)
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IGF-1 enhances the osteogenic activity of BMP-6 in vitro and in vivo
Rico-Llanos, Gustavo Adolfo; Becerra-Ratia, José; Visser, Rick (2017-10-25)
Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and alternatives are being ... -
IGF-1 enhances the osteogenic activity of BMP-6 in vitro and in vivo, and together have a stronger osteogenic effect than when IGF-1 is combined with BMP-2
Rico-Llanos, Gustavo Adolfo; Becerra-Ratia, José; Visser, Rick (2017-11-24)
Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and alternatives are being ... -
In vitro stimulation of MC3T3-E1cells and sustained drug delivery by a hierarchical nanostructured SiO2-CaO-P2O5 scaffold
Ramiro-Gutiérrez, María Lourdes; Santos-Ruiz, Leonor; Borrego-González, Sara; Becerra-Ratia, José; Díaz-Cuenca, Aránzazu (Elsevier, 2016-07-15)
A hierarchical scaffold, SP1_h_HA, consisting of a biomimetic nano-hydroxyapatite surface coating growth onto a reticulated structure having a nano-organized porous texture was fabricated and functionally studied in vitro ...