Listar por autor "Sánchez-Jiménez, Francisca María"
Mostrando ítems 1-15 de 15
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A role for antizyme inhibitor 2 in the biosynthesis and content of histamine and serotonin in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, José Luis
; Sánchez-Jiménez, Francisca María; Peñafiel, Rafael; Fajardo-Paredes, Ignacio José[et al.] (2015-09-14)
Polyamines (putrescine, spermidine and spermine; PAs) are required for the survival of the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine ... -
A role for antizyme inhibitor 2 in the biosynthesis and content of serotonin and histamine in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Peñafiel, Rafael; Fajardo-Paredes, Ignacio José[et al.] (2015-09-04)
Polyamines (putrescine, spermidine and spermine; PAs) are essential for the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase and PA ... -
Aminooxi análogos de histidina: una posible estrategia para modular la histidina descarboxilasa humana.
Sánchez-Jiménez, Francisca María (2014-09-26)
La histamina (Hia) es una amina biógena implicada en procesos fisiológicos esenciales (respuesta inmune, neurotransmisión y otros). El desequilibrio de su metabolismo juega un destacado papel en muchas patologías. El control ... -
AMMO-Prot: Amine system project 3D-model finder
Navas-Delgado, Ismael; Pino-Ángeles, Almudena; Montañez, Raúl; Moya-García, Aurelio Ángel; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Aldana-Montes, José Francisco[et al.] (Springer Nature, 2008-04)
Background: Amines are biogenic amino acid derivatives, which play pleiotropic and very important yet complex roles in animal physiology. For many other relevant biomolecules, biochemical and molecular data are being ... -
Análisis de relaciones fenotípicas mediante el uso de ontologías biomédicas: aplicaciones a enfermedades genéticas
(UMA Editorial, 2017-11-09)El incremento en la eficiencia de las técnicas de alto rendimiento y el avance de los métodos de integración y análisis de información, han permitido estudiar las enfermedades integrando varios niveles de complejidad. El ... -
Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients
López-Gómez, Carlos; Pino-Ángeles, Almudena; Órpez-Zafra, Teresa; Pinto-Medel, Mª Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Arnáiz, Carlos; Guijarro-Castro, Cristina; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Sánchez-Jiménez, Francisca María; Fernández Fernández, Oscar; Leyva-Fernández, Laura[et al.] (Public Library of Sciences, 2013)
TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of these genes in relation to ... -
Exploring and challenging the network of angiogenesis
Montañez, Raúl; Sánchez-Jiménez, Francisca María; Medina, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer Nature, 2011-08-11)
Angiogenesis is one of the hallmarks of cancer and, as such, one of the alternative general targets for anticancer therapy. Since angiogenesis is a complex process involving a high number of interconnected components, a ... -
Mathematical Modeling of Polyamine Metabolism in Mammals.
Rodríguez-Caso, Carlos Francisco; Montañez, Raúl; Cascante, Marta; Sánchez-Jiménez, Francisca María; Medina-Torres, Miguel Ángel (Elsevier, 2006)
Polyamines are considered as essential compounds in living cells, since they are involved in cell proliferation, transcription, and translation processes. Furthermore, polyamine homeostasis is necessary to cell survival, ... -
Network perspective of histamine related diseases
Moya-García, Aurelio Ángel; Rodríguez-López, Rocío; Medina-Torres, Miguel Ángel; Sánchez-Jiménez, Francisca María (2017-08-29)
Histamine is the most pleiotropic biogenic amine. Produced and stored by a limited set of cells—histaminergic neurons, enterochromaffin-like cells, and mast cells—it broadcasts intercellular communication signals to a wide ... -
New findings on the cellular effects of newly synthetized histamine in mammalian cells
Histamine (Hia) is the most multifunctional biogenic amine. It is synthetized by histidine decarboxylase (HDC) in a reduced set of mammalian cell types. Mast cells and histaminergic neurons store Hia in specialized organelles ... -
Polyamines and other biogenic amines at the molecular basis of low prevalence diseases
Sánchez-Jiménez, Francisca María (2014-09-26)
Biogenic amines are amino acid-derived compounds involved in the most important physiological functions: cell proliferation and differentiation, immunity, neurotransmission and neuroendocrine system, fertility. Diseases ... -
Una propuesta de la biología de sistemas para el estudio de enfermedades raras
Sánchez-Jiménez, Francisca María (UMA / SEDOC, 2010)
El grupo de Bases Moleculares de la Proliferación Celular de la Universidad de Málaga estudia patologías muy poco convencionales. Su poca incidencia en la población, menos de cinco casos por cada diez mil habitantes, las ... -
Sensitivity of polyamine metabolism to glucose deprivation is increased in neuroblastoma cells with N-myc amplification
Ruiz-Pérez, M. Victoria; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Medina-Torres, Miguel Ángel (2014-07-10)
Ornithine-derived polyamines are essential for cell proliferation, and their levels are elevated in many human tumors. Neuroblastoma, the most frequent extra-cranial solid tumor in children, harbors amplification of n-myc ... -
Structural and functional interaction between polyamine related molecules and biological membranes
Acosta-Andrade, Carlos; Artetxe, I; Lete, MG; Ruiz-Mirazo, Kepa; Goñi, Félix; Urdiales-Ruiz, José Luis; Fajardo-Paredes, Ignacio José; Sánchez-Jiménez, Francisca María[et al.] (2016-09-22)
Changes induced by PA on nucleic acid (NA) conformation and synthesis is proven to be a major reason for PA essentiality (1-3). However, PA interactions with other polyanions, for instance polyanionic membrane lipid bilayers ... -
Systems Biology Approaches to Evaluate Disease Modularity
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)Biological systems are in a constant process of innovation as an essential precondition to evolve. For this reason, the emergence of phenotypic variation is an inherent property of complex adaptive systems. Even though ...