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Listar por autor "Santin-Nuñez, Luis Javier"
Mostrando ítems 1-9 de 9
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Efectos de la Palmitoiletanolamida en la adicción a cocaína: influencia en la sensibilización conductual y en el condicionamiento preferencial de lugar.
Zambrana-Infantes, Emma (UMA Editorial, 2016)La adicción a cocaína supone un problema, tanto a nivel individual como social, puesto que conlleva numerosas complicaciones sanitarias para los consumidores e importantes costes económicos para el sistema de salud. La ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara Miranda, David; Gil Rodríguez, Sara; Rodríguez de Fonseca, Fernando; [et al.] (2019-07-03)Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil-Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill Torrús, Guillermo; [et al.] (2018-06-28)Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millon, Carmelo; Puigcerver-Martinez, Araceli; Gago, Belén; García-Durán, Laura; [et al.] (2019-06-17)Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millón, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, Estela; Gago, Belén; Serrano, Antonia; [et al.] (2018-06-28)Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Improvement on hippocampal neuroproliferation through galanin and neuropeptide y y1 receptor agonist interaction
Narváez, Manuel; Santin-Nuñez, Luis Javier; Tif, Maria; Fuxe, Kjell; Borroto-Escuela, Dasiel (2019-09-11)Neurogenesis persists in the hippocampus throughout the lifespan in a wide variety of species including humans. Within the dentate gyrus of the hippocampus, the subgranular zone (SGZ) is maintained as a stem cell niche. ... -
Social avoidance and altered stress axis in a mouse model of anxious depression
Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Moreno-Fernández, Román; Rosell-del-Valle, Cristina; Pérez-Martín, Margarita; [et al.] (2018-07-17)Prevalence of stress-related disorders, such as depression, is raising in modern societies. Indeed, current neurobiological research aims to elucidate the link between deregulation of the hypothalamic-pituitary-adrenal ... -
Stress coping behaviour, brain connectivity and LPA1 receptor: similarities and differences between the genetic and the pharmacological approach
Moreno-Fernández, Román; Nieto-Quero, Andrea; Gómez-Salas, Francisco Javier; Tabbai-Amal, Sara; García-Fernández, María; [et al.] (2018-07-16)LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signalling molecule. It has been recently proposed that this receptor has a ... -
Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment
Moreno-Fernández, Román; Bacq, Alexandre; Rosell-Valle, Crisitina; Zanoletti, Olivia; Cifuentes, Manuel; [et al.] (2019-06-25)The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ...