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A Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in rats
Millón, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; [et al.] (2015-10-06)Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been ... -
Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gomez-Salas, Francisco J.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2016-07-20)Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2018-07-18)LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Alteraciones motoras, cognitivas y emocionales en la encefalomielitis autoinmune experimental
Sánchez Morales, Cristina (2017-02-17)La esclerosis múltiple (EM) es una enfermedad neuroinflamatoria y desmielinizante del sistema nervioso central (SNC). Actualmente, el modelo animal experimental más adecuado para la EM humana es la encefalomielitis ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez, Manuel; Borroto-Escuela, Dasiel; Millon, Carmelo; Gago, Belén; Flores-Burgess, Antonio; [et al.] (2017-08-30)Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Aspectos emocionales y cognitivos relacionados con el consumo de cocaína: Correlatos neurobiológicos y papel de la plasticidad hipocampal
Ladron De Guevara Miranda, David (UMA Editorial, 2019-11)El consumo de sustancias de abuso constituye un problema mundial para el que aún no existen soluciones plenamente satisfactorias. En concreto, la cocaína es una de las drogas ilegales con mayor repercusión, debido a sus ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; [et al.] (2016-07-13)Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Cognitive impairment in a murine model of experimental autoimmune encephalomyelitis with relapsing-remitting course
Rosell-del-Valle, Cristina; Sánchez-Morales, Cristina; Gómez-Conde, Ana Isabel; Hurtado-Guerrero, Isaac; Fernández-Fernández, Óscar; [et al.] (2015-09-18)Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by demyelination and progressive axonal loss that affects the central nervous system. In addition of physical disability and the neurodegenerative ... -
Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
Sampedro-Piquero, Patricia; Vicario, Selene; Pérez-Rivas, Aroa; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis Javier (2020-03-17)Introduction: The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura; Gago, Belén; Flores-Burgess, Antonio; Alén, Francisco; [et al.] (2019-09-10)Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
Efecto neuroprotector de IGF-II en situaciones de estrés neuronal inducido por corticosterona
Aguirre-Gomez, Jose Angel; Martinez-Montañez, Elisa; Pavia-Molina, Jose; Santin-Nuñez, Luis Javier; Estivill-Torrus, Guillermo; [et al.] (2013-10-02)El daño por estrés en tejido neuronal mediado por la presencia de elevados niveles de corticosterona, se relaciona con la producción de alteraciones en funciones cognitivas. Así, el estrés agudo induce un aumento importante ... -
Efectos de la Palmitoiletanolamida en la adicción a cocaína: influencia en la sensibilización conductual y en el condicionamiento preferencial de lugar.
Zambrana-Infantes, Emma (UMA Editorial, 2016)La adicción a cocaína supone un problema, tanto a nivel individual como social, puesto que conlleva numerosas complicaciones sanitarias para los consumidores e importantes costes económicos para el sistema de salud. La ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara Miranda, David; Gil Rodríguez, Sara; Rodríguez de Fonseca, Fernando; [et al.] (2019-07-03)Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón, Carmelo; Flores-Burgess, Antonio; Gago, Belén; García-Durán, Laura; Cantero-García, Noelia; [et al.] (2019-11-18)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago, Belén; Allén, Francisco; [et al.] (2019-09-12)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
Garcia-Cantero, Noelia; Flores-Burgess, Antonio; Gago, Belén; García-Durán, Laura; Alén, Francisco; [et al.] (2021-01-22)The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
Effects of galanin n-terminal fragment (1-15) in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millón, Carmelo; Narváez, Manuel; Santin-Nuñez, Luis Javier; Narváez, José Ángel; [et al.] (2015-10-21)Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. The intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) and an ... -
Effects of palmitoylethanolamide in cocaine-induced behaviours
Santin-Nuñez, Luis Javier; Zambrana-Infantes, Emma; Galeano, Pablo; Rosell del Valle, Cristina; Ladrón de Guevara-Miranda, David; [et al.] (2016-07-13)Aims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara Miranda, David; Gil Rodríguez, Sara; Rodríguez de Fonseca, Fernando; [et al.] (2019-10-01)Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil-Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill Torrús, Guillermo; [et al.] (2018-06-28)Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ...