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A Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in rats
Millón, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; [et al.] (2015-10-06)Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been ... -
Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2016-07-20)Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-Valle, Cristina; Castilla-Ortega, Estela; [et al.] (2018-07-18)LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments
Castilla-Ortega, E.; Santin-Nuñez, Luis Javier (Elsevier, 2020)Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate ... -
Alteraciones motoras, cognitivas y emocionales en la encefalomielitis autoinmune experimental
Sánchez Morales, Cristina (2017-02-17)La esclerosis múltiple (EM) es una enfermedad neuroinflamatoria y desmielinizante del sistema nervioso central (SNC). Actualmente, el modelo animal experimental más adecuado para la EM humana es la encefalomielitis ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez, Manuel; Borroto-Escuela, Dasiel; Millón, Carmelo; Gago, Belén; Flores-Burgess, Antonio; [et al.] (2017-08-30)Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Aspectos emocionales y cognitivos relacionados con el consumo de cocaína: Correlatos neurobiológicos y papel de la plasticidad hipocampal
Ladrón de Guevara-Miranda, David (UMA Editorial, 2019-11)El consumo de sustancias de abuso constituye un problema mundial para el que aún no existen soluciones plenamente satisfactorias. En concreto, la cocaína es una de las drogas ilegales con mayor repercusión, debido a sus ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; [et al.] (2016-07-13)Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Central administration of Galanin-N terminal fragment 1-15 decreases the voluntary alcohol intake in rats
Millón, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, Estela; Gago, Belén; García-Fernandez, María; [et al.] (2019) -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-Valle, Cristina; Pedraza-Benítez, Maria del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; [et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero-Zerbo, Silvana Y.; [et al.] (2022-07)Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodríguez de Fonseca, Fernando; [et al.] (2021)Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, ... -
Cognitive impairment in a murine model of experimental autoimmune encephalomyelitis with relapsing-remitting course
Rosell-del-Valle, Cristina; Sánchez-Morales, Cristina; Gómez-Conde, Ana Isabel; Hurtado-Guerrero, Isaac; Fernández-Fernández, Óscar; [et al.] (2015-09-18)Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by demyelination and progressive axonal loss that affects the central nervous system. In addition of physical disability and the neurodegenerative ... -
Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
Sampedro-Piquero, Patricia; Vicario, Selene; Pérez-Rivas, Aroa; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis Javier (2020-03-17)Introduction: The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive ... -
Cognitive reserve mediates the severity of certain neuropsychological deficits related to cocaine use disorder
Vicario, Selene; Pérez-Rivas, Aroa; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis Javier; Sampedro-Piquero, Patricia (Elsevier, 2020-08)The concept of cognitive reserve (CR) is being considered in the field of substance use disorder (SUD) by observing that there are individuals whose brain alterations are not related to the cognitive symptomatology they ... -
Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
Nieto-Quero, Andrea; Chaves-Peña, Patricia; Santin-Nuñez, Luis Javier; Pérez-Martín, Margarita; Pedraza-Benítez, Maria del Carmen (ELSEVIER, 2021-11)Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura; Gago, Belén; Flores-Burgess, Antonio; Alén, Francisco; [et al.] (2019-09-10)Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
Efecto neuroprotector de IGF-II en situaciones de estrés neuronal inducido por corticosterona
Aguirre-Gomez, Jose Angel; Martinez-Montañez, Elisa; Pavia-Molina, Jose; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo; [et al.] (2013-10-02)El daño por estrés en tejido neuronal mediado por la presencia de elevados niveles de corticosterona, se relaciona con la producción de alteraciones en funciones cognitivas. Así, el estrés agudo induce un aumento importante ... -
Efectos de la Palmitoiletanolamida en la adicción a cocaína: influencia en la sensibilización conductual y en el condicionamiento preferencial de lugar.
Zambrana-Infantes, Emma (UMA Editorial, 2016)La adicción a cocaína supone un problema, tanto a nivel individual como social, puesto que conlleva numerosas complicaciones sanitarias para los consumidores e importantes costes económicos para el sistema de salud. La ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodríguez de Fonseca, Fernando; [et al.] (2019-07-03)Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ...