his PhD Thesis proposes the discovery and development of new drugs inspired by bioactive natural products, which represent valid platforms for the generation of new chemical entities of pharmaceutical interest. In particular, ...

(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ...