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Listar por autor "Sarabia-Garcia, Francisco Ramon"
Mostrando ítems 1-8 de 8
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Explorando la química de los iluros de azufre en la síntesis de antibióticos tipo nucleósido: aproximación sintética de liposidomicinas y muraimicinas
Martín Ortiz, Laura (Universidad de Málaga,Servicio de Publicaciones, 2006)El trabajo de investigación desarrollado y expuesto en la presente memoria de Tesis Doctoral, muestra una nueva metodología sintética, basada en la química de los iluros de azufre, bien estudiada en el grupo de ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; Carrillo Fernández, Paloma; [et al.] (2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
An Olefin Metathesis-Based Strategy for the Synthesis of New Antitumoral Compounds Inspired by Natural Products
Cheng Sanchez, Ivan (UMA Editorial, 2019)his PhD Thesis proposes the discovery and development of new drugs inspired by bioactive natural products, which represent valid platforms for the generation of new chemical entities of pharmaceutical interest. In particular, ... -
Síntesis estereoselectiva de amidas glicídicas vía una nueva clase de sales de sulfonio quirales: aplicaciones en síntesis de productos naturales
Vivar García, Carlos (Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)En esta tesis se explora una nueva metodología de síntesis asimétrica de epóxidos mediante el uso de una nueva clase de sales de sulfonio quirales derivadas de aminoácidos y caracterizadas por una estructura bicíclica. Las ... -
Stereoselective synthesis of epoxides and diepoxides. Applications in total synthesis of natural products and analogues
García Ruiz, María Cristina (Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)The present work is on the total synthesis of the natural compounds and/or analogues of Bengamides, Gummiferol and Depudecin. The target molecules, selected in virtue of their prominent biological activity as antibiotic ... -
Synthesis and biological activity of a new class of antitumor cyclopeptides based on the solomonamides
Cheng-Sánchez, Iván; Carrillo, Paloma; Martínez-Poveda, Beatriz; Quesada, Ana R.; Medina, Miguel Ángel; [et al.] (2018-10-15)Solomonamides A (1) and B (2) are novel natural products recently isolated from the marine sponge Theonella swinhoei [1]. Preliminary structural studies revealed an unprecedented cyclic peptide type structure. Interestingly, ... -
Synthesis and Biological Evaluation of Depudecin Analogues
Cheng-Sánchez, Iván; Carrillo, Paloma; García-Ruiz, Cristina; Martínez-Poveda, Beatriz; Quesada, Ana R.; [et al.] (2019-09-18)(-)-Depudecin (1) (Figure 1), isolated from the culture broths of the fungus Alternaria brassicicola,1 and later, from the weed pathogen Nimbya scirpicola,2 has been identified as a selective inhibitor of histone deacetylases ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; [et al.] (IOAP-MPDI, 2022-05-31)The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ...