Listar por autor "Phan, Jimmy"
Mostrando ítems 1-3 de 3
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Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Cadete Martini, Alessandra; Gomez-Arboledas, Angela; Forner, Stefania; Rodriguez-Ortiz, Carlos; McQuade, Amanda; Danhash, Emma; Phan, Jimmy; Javoncillo, Dominic; Ha, Jordan-Vu; Tram, Melanie; Trujillo-Estrada, Laura Isabel
; da Cunha, Celia; Ager, Rahasson; Davila, Jose Carlos; Kitazawa, Masashi; Blurton-Jones, Mathew; Gutierrez, Antonia; Baglietto-Vargas, David; Medeiros, Rodrigo; LaFerla, Frank M[et al.] (National Academy of Sciences, 2019-10)
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the ... -
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
(Springer Nature, 2021-04-23)The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ... -
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus
Forner, Stefania; Martini, Alessandra; Prieto, Gilberto Aleph; Dang, Cindy; Rodriguez-Ortiz, Carlos; Reyes Ruiz, Jorge Mauricio; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Andrews, Elizabeth; Phan, Jimmy; Ha, Jordan; Chang, Allissa; Levites, Yona; Cruz, Pedro; Ager, Rahasson; Medeiros, Rodrigo; Kitazawa, Masashi; Glabe, Charles; Cotman, Carl; Golde, Todd; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Springer Nature, 2019-11)
Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with ...