Listar por autor "Nuñez-Diaz, Cristina"
Mostrando ítems 1-13 de 13
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Amyloid propagation in a sporadic model of Alzheimer disease
Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; Cheung, Alwin; Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel
; Nuñez-Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutierrez-Perez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2021-11-04)
Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura Isabel; Sanchez-Varo, Raquel; Dávila-Cansino, José Carlos; Dávila-Cansino, José Carlos; Gutierrez-Perez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Sanchez-Varo, Raquel; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-18)
The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2018-07-20)
AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Romero-Molina, Carmen; Sanchez-Mejias, Elisabet; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Navarro, Victoria; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-19)
Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Human amyloid seeds aggregate more efficient than seeds from old 3xtg-ad mice
Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Thu Nguyen, Marie Minh; Cheung, Alwin; Tran, Janine Pham; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Nuñez-Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutierrez-Perez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2022)
Aims: Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Jimenez, Sebastian; Sanchez-Varo, Raquel; Muñoz-Castro, Clara; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2018-07-20)
Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Sanchez-Varo, Raquel; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-17)
The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gómez-Arboledas, Ángela; Moreno González, Inés; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2020-12-17)
Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sanchez-Mejias, Elisabet; Navarro, V; Jimenez, Sebastian; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Moreno-Gonzalez, Ines; Moyano, F; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
The effect of different amyloid seeds and animal hosts on amyloid propagation in Alzheimer's Disease
Andreo-Lopez, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Thu Nguyen, Marie Minh; Cheung, Alwin; Pham Tran, Janine; Trujillo-Estrada, Laura Isabel; Nuñez-Diaz, Cristina; Martini, Alessandra; Forner, Stefania; Gutierrez-Perez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2022-07-13)
Abstract text: Alzheimer's Disease is a neurodegenerative proteinopathy in which recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Sanchez-Varo, Raquel; Jimenez, Sebastian; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2021-03-09)
Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ...