Listar por autor "Álvarez-Contino, José Erik"
Mostrando ítems 1-9 de 9
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Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion
Díaz-Sánchez, Estela; López-Salas, Alexander; Mirchandani-Duque, Marina; Álvarez-Contino, José Erik; Sánchez-Pérez, José Andrés; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia
; Narváez-Peláez, Manuel[et al.] (Elsevier, 2023)
Different brain regions’ interactions have been implicated in relevant neurological diseases, such as major depressive disorder (MDD), anxiety disorders, age-dependent cognitive decline, Alzheimer’s disease (AD) and addiction. ... -
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.
Sánchez-Varo, Raquel María; López-Salas, Alexander; Rasiel, Beltran-Casanueva; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (Springer Nature, 2024-03-28)
Background: Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This ... -
Evidence for a synergistic effect of NPY1R agonist co-administered with Ketamine in rats: relevance to neurodegenerative and mood disorders.
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Beltrán-Casanueva, Rasiel; Hernández-García, Aracelis; Bayolo-Guanche, Juan Vicente; Romero-Imbroda, Jesús; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Serrano-Castro, Pedro; Narváez-Peláez, Manuel[et al.] (2024)
Introduction/Objetives: Major depressive disorder is one of the most prevalent health problems worldwide and its current therapeutic approach still generates great dissatisfaction due to its limited efficacy, unwanted ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (IOAP-MPDI, 2022-06-01)
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (2022-09-22)
Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses ... -
GALR2 and Y1R agonists intranasal infusion enhanced adultventral hippocampal neurogenesis and antidepressant‐likeeffects involving BDNF actions
Álvarez-Contino, José Erik; Díaz-Sánchez, Estela; Mirchandani-Duque, Marina; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; Narváez-Peláez, Manuel[et al.] (Wiley, 2023)
Dysregulation of adult hippocampal neurogenesis is linked to major depressive disorder(MDD), with more than 300 million people diagnosed and worsened by the COVID‐19pandemic. Accumulating evidence for neuropeptideY (NPY) ... -
On the Role of Neuropeptide Y Receptor 1 (NPY1R)-Galanin Receptor 2 (GALR2) Heteroreceptor Complexes in Enhancing Adult Hippocampal Neurogenesis and Cognitive Function
(UMA Editorial, 2024-09)This PhD thesis investigates the roles of Neuropeptide Y receptor 1 (NPY1R) homo- and heteroreceptor complexes, specifically NPY1R- galanin receptor 2 (GALR2) heteroreceptor complexes, within the Central Nervous System ... -
Synergistic Effects of Intranasally Administered GALR2 and Y1R Agonists on Cognitive and Mood-Related Behaviors in Adult Rats: Implications for Neurodegenerative and Mood Disorders
Moreno Madrid, Isabel; Arrabal-Gómez, José Carlos; Serrano-Castro, Pedro; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel-Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2024-06)
Abstract body: Background: The complexity of neurodegenerative and mood disorders necessitates innovative therapeutic strategies beyond current treatments. This study explores the combined therapeutic potential of Galanin ... -
Unveiling the Synergistic Interplay of Neuropeptides for Novel Therapeutic Approaches in Neurodegenerative and Depressive Disorders.
Díaz-Sánchez, Estela; López-Salas, Alexander; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Brito Rodríguez, Ismel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2023)
The intricate relationship between hippocampal neurogenesis dysregulation and neurodegenerative diseases such as Alzheimer's, as well as depression, has sparked an urgent call for innovative therapeutic strategies. Our ...