Listar por autor "Campos-Sandoval, José Ángel"
Mostrando ítems 1-15 de 15
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Antioxidant responses related to temozolomide resistance in glioblastoma
Campos-Sandoval, José Ángel
; Gómez-García, María C.; Santos-Jiménez, Juan de los; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier[et al.] (Elsevier, 2021)
Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ... -
Changes in the nuclear proteomic profiling of human glioblastoma cells after glutaminase overexpression
Márquez-Gómez, Javier; Cardona Ramírez, Carolina; Alonso-Carrión, Francisco José; Lobo, Carolina; Campos-Sandoval, José Ángel; Martín Rufián, Mercedes[et al.] (2013)
Human glutaminase (GA) enzymes are the products of two genes, GLS and GLS2. GA isozymes play markedly different roles in tumour biology: GLS isoforms (KGA and GAC) are related to cell growth and proliferation, whereas GLS2 ... -
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice
Blanco-Calvo, Eduardo; Campos-Sandoval, José Ángel; Palomino, Ana; Luque-Rojas, María Jesús; Bilbao, Ainhoa; Suárez, Juan; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons. The role of both enzymes in psychopharmacological responses ... -
Design and generation of a glutaminase GLS2 conditional knockout mice
Peñalver, Ana; Tosina, Marta; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Ramírez, Miguel Ángel; Gutiérrez-Adán, Alfonso; Márquez-Gómez, Javier[et al.] (2014-10-04)
Mammalian glutaminase (GA; EC 3.5.1.2) is the main enzyme involved in brain generation of glutamate (Glu). This amino acid acts as an excitatory neurotransmitter within the CNS, and it is also implicated in behavioral ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Cardona, Carolina; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Vitorica, Javier; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Segura-Checa, Juan Antonio; Norenberg, Michael D.; Rama Rao, Kakulavarapu V.; Jayakumar, Arumugan R.; Gutiérrez-Pérez, Antonia; Márquez-Gómez, Javier[et al.] (Wiley, 2015-03)
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glu-taminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Cardona, Carolina; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Vitorica Ferrández, Javier; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Segura-Checa, Juan Antonio; Norenberg, Michael; Rama Rao, Kakulavarapu; Jayakumar, Arumugan; Gutiérrez-Pérez, Antonia; Márquez-Gómez, Javier[et al.] (Wiley, 2015)
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glutaminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel (MDPI, 2024-06-20)
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver Alonso, Ana; Campos-Sandoval, José Ángel; Blanco-Calvo, Eduardo; Cardona Ramírez, Carolina; Castilla, Laura; Martín-Rufián, Mercedes; Estivill-Torrús, Guillermo; Sánchez-Varo, Raquel María; Alonso-Carrión, Francisco José; Pérez-Hernández, Mercedes; Colado, María Isabel; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (Frontiers, 2017-09-05)
Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)
Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
Ojeda-Pérez, Betsaida; Campos-Sandoval, José Ángel; García-Bonilla, María; Cárdenas García, Casimiro; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (BMC, 2021)
Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter is the most ... -
Lysophosphatidic Acid and Glutamatergic Transmission.
Roza, Carolina; Campos-Sandoval, José Ángel; Gómez García, María del Carmen; Peñalver Alonso, Ana; Márquez-Gómez, Javier (Frontiers, 2019-05-28)
Signaling through bioactive lipids regulates nervous system development and functions. Lysophosphatidic acid (LPA), a membrane-derived lipid mediator particularly enriched in brain, is able to induce many responses in ... -
Mammalian Glutaminase Gls2 Gene Encodes Two Functional Alternative Transcripts by a Surrogate Promoter Usage Mechanism.
Martín-Rufián, Mercedes; Tosina, Marta; Campos-Sandoval, José Ángel; Manzanares, Elisa; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Márquez-Gómez, Javier[et al.] (PLOS, 2012-06-05)
Glutaminase is expressed in most mammalian tissues and cancer cells, but the regulation of its expression is poorly understood. An essential step to accomplish this goal is the characterization of its species- and cell-specific ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Ratones knock-out del receptor lpa1 de ácido lisofosfatídico presentan un acusado déficit de la isoenzima glutaminasa KGA (GLS) y una morfología alterada en las espinas dendríticas de hipocampo y corteza
Peñalver, Ana; Campos-Sandoval, José Ángel; Sánchez-Varo, Raquel María; Cardona Ramírez, Carolina; Castilla, Laura; Blanco, Eduardo; Martín-Rufián, Mercedes; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (2015-09-25)
Objectives: The objective of the present study was to utilize mice with knocked-down lysophosphatidic acid 1 (LPA1) receptor to ascertain changes in glutamatergic transmission that may help to explain part of the cognitive ... -
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Mates-Sánchez, José Manuel; di Paola, Floriana J.; Campos-Sandoval, José Ángel; Mazurek, Sybille; Márquez-Gómez, Javier (Elsevier, 2020-02)
Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy, biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine is also a ...