Listar por autor "Castilla-Ortega, Maria Estela"
Mostrando ítems 1-20 de 34
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Absence of LPA1 receptor results in altered pattern of limbic activation after tail suspension test
Moreno-Fernández, Román D.; Gómez-Salas, Francisco Javier; Pérez-Martín, Margarita
; Rosell-del-Valle, Cristina; Castilla-Ortega, Maria Estela; García-Fernández, Maria Inmaculada; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2016-07-20)
Stress serves as an adaptive mechanism and helps organisms to cope with life-threatening situations. However, individual vulnerability to stress and dysregulation of this system may precipitate stress-related disorders ... -
The absence of LPA1 receptor results in lipidome dysregulation and Neuropeptide-Y underexpression
Tabbai, Sara; Moreno-Fernández, Román D.; Pérez-Martín, Margarita; Rosell-del-Valle, Cristina; Castilla-Ortega, Maria Estela; Fernández, María; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo; Santin-Nuñez, Luis Javier; Pedraza-Benítez, Maria del Carmen[et al.] (2018-07-18)
LPA1 receptor is one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts as an intercellular signaling molecule. It has been shown that the LPA1 receptor is involved in ... -
Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments
Castilla-Ortega, Maria Estela; Santin-Nuñez, Luis Javier (Elsevier, 2020)
Basic research in rodents has shown that adult hippocampal neurogenesis (AHN) plays a key role in neuropsychiatric disorders that compromise hippocampal functioning. The discovery that dependence-inducing drugs regulate ... -
Aspectos emocionales y cognitivos relacionados con el consumo de cocaína: Correlatos neurobiológicos y papel de la plasticidad hipocampal
(UMA Editorial, 2019-11)El consumo de sustancias de abuso constituye un problema mundial para el que aún no existen soluciones plenamente satisfactorias. En concreto, la cocaína es una de las drogas ilegales con mayor repercusión, debido a sus ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; Suárez, Juan; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, Maria Estela[et al.] (2016-07-13)
Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Chronic central modulation of LPA/LPA receptors-signaling pathway in the mouse brain regulates cognition, emotion, and hippocampal neurogenesis.
Rosell-del-Valle, Cristina; Pedraza-Benítez, Maria del Carmen; Manuel, Iván; Moreno-Rodríguez, Marta; Rodríguez-Puertas, Rafael; Castilla-Ortega, Maria Estela; Carames-Tejedor, Jose Maria; Gómez-Conde, Ana Isabel; Zambrana-Infantes, Emma; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesus; Chun, Jerold; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Estivill-Torrús, Guillermo[et al.] (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021-06-06)
Several studies have demonstrated that lysophosphatidic acid (LPA) acts through its LPA receptors in multiple biological and behavioral processes, including adult hippocampal neurogenesis, hippocampal-dependent memory, and ... -
Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, Maria Estela[et al.] (2021)
Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, ... -
Educación superior y emociones, bases epistemológicas de Maturana
Mañas Padilla, María del Carmen; Edelkraut, Lisa; Castilla-Ortega, Maria Estela; Araos, Pedro (2021-11-20)
Introducción. Las emociones serán entendidas como las disposiciones corporales que especifican el dominio de acción en que ese mueve el organismo. Son el fundamento de muchos aspectos de la vida y la educación es parte de ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, Maria Estela; Santin-Nuñez, Luis Javier[et al.] (2019-07-03)
Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
Effects of palmitoylethanolamide in cocaine-induced behaviours
Santin-Nuñez, Luis Javier; Zambrana-Infantes, Emma; Galeano, Pablo; Rosell-del-Valle, Cristina; Ladrón de Guevara-Miranda, David; Castilla-Ortega, Maria Estela; Rodriguez-de-Fonseca, Fernando; Blanco-Calvo, Eduardo[et al.] (2016-07-13)
Aims. Cocaine addiction is a chronically relapsing disorder characterized by the compulsion to seek and take the drug. Previous investigations have demonstrated that several drugs of abuse, as cocaine, can alter the levels ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, Maria Estela; Santin-Nuñez, Luis Javier[et al.] (2019-10-01)
Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Enhancing adult hippocampal neurogenesis with lysophosphatidic acid: a proposal for erasing cocaine contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, Maria Estela[et al.] (2018-06-28)
Stimulating adult hippocampal neurogenesis (AHN) has been uncovered as a promising approach in the manipulation of retrograde memories. This work aims to study whether increasing AHN with lysophosphatidic acid (LPA, an ... -
Estudio del cacao como potenciador de la neurogénesis y la función hipocampal en ratones adultos
Introducción: La formación de nuevas neuronas es un fenómeno neuroplástico esencial que se produce en el cerebro adulto, concretamente en el giro dentado del hipocampo (neurogénesis hipocampal adulta, NHA). Numerosos ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, Maria Estela; Gago-Calderon, Belen; Serrano, Antonia; Sturla, Antonella; Garcia-Duran, Laura; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2018-06-28)
Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Highlighting the role of cognitive and brain reserve in the substance use disorder field
Culuti, D; Ladrón de Guevara-Miranda, David; Castilla-Ortega, Maria Estela; Santin-Nuñez, Luis Javier; Sampedro-Piquero, Patricia (Bentham Science Publishers, 2019)
Background: Cognitive reserve (CR) refers to the ability of an individual to cope with brain pathology remaining free of cognitive symptoms. This protective factor has been related to compensatory and more efficient brain ... -
LPA1/3 receptor antagonist KI16425 as a novel treatment for the neurobehavioural effects of the ethanol
Ladrón de Guevara-Miranda, David; Sánchez-Marín, Laura; Alén, Francisco; Moreno-Fernández, Román D.; García-Fernández, Maria Inmaculada; Gil Rodríguez, Sara; Gavito, Ana; García-Marchena, Nuria; Pedraza-Benítez, Maria del Carmen; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Serrano, Antonia; Castilla-Ortega, Maria Estela[et al.] (2017-07-24)
Aims. The lysophosphatidic acid (LPA) is an ubiquitous lysophospholipid that acts through G-protein coupled receptors (LPA1-6), and it is involved in the modulation of emotional and motivational behaviors. Recent literature ... -
Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, Maria Estela[et al.] (Wiley, 2019)
Erasing memories of cocaine-stimuli associations might have important clinical implications for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal neurogenesis (AHN) is a promising strategy ... -
More adult-born dentate gyrus neurons to weaken cocaine-related retrograde memories: an in vivo strategy employing exogenous lysophosphatidic acid
Ladrón de Guevara-Miranda, David; Moreno-Fernández, Román D.; Gil Rodríguez, Sara; Rosell-del-Valle, Cristina; Estivill-Torrús, Guillermo; Serrano, Antonia; Pavón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, Maria Estela[et al.] (2019-10-28)
The post-training enhancement of adult hippocampal neurogenesis (AHN) has been receiving growing interest as a potential method to manipulate retrograde memories. Recent hypothesis suggest that the addition of adult-born ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Pavón, F.J.; Serrano, A; Suarez, J; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, Maria Estela[et al.] (Elsevier, 2019)
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ...