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Listar por autor "Clemente-Postigo, María Mercedes"
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8-oxoguanine DNA glycosylase 1 upregulation as a risk factor for obesity and colorectal cancer
Pilo, Jesús; García-Flores, Libia Alejandra; Clemente-Postigo, María Mercedes; Arranz-Salas, Isabel María; Alcaide, Julia; Ramos-Fernandez, Maria; Lozano-Castro, José; Boughanem Lakhal, Hatim; Kompella, Pallavi; Macías-González, Manuel[et al.] (MDPI, 2023-03-13)DNA damage has been extensively studied as a potentially helpful tool in assessing and preventing cancer, having been widely associated with the deregulation of DNA damage repair (DDR) genes and with an increased risk of ... -
Adipogenic Impairment of Adipose Tissue-Derived Mesenchymal Stem Cells in Subjects With Metabolic Syndrome: Possible Protective Role of FGF2
Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Lhamyani, Said; Clemente-Postigo, María Mercedes; Alcaide Torres, Juan; Bernal-López, María Rosa; El-Bekay, Rajaa; Tinahones-Madueño, Francisco José[et al.] (Endocrine Society, 2017)Context: The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome. Objetive: The aim of this study was to examine the state of adipose tissue-derived ... -
Adipose tissue gene expression of factors related to lipid processing in obesity
Clemente-Postigo, María Mercedes; Queipo Ortuño, María Isabel; Fernandez-García, Diego; Gómez-Huelgas, Ricardo; Tinahones, Francisco J; Cardona, Fernando[et al.] (PLOS One, 2011)Background Adipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is the first step to adipose tissue lipid ... -
Adipose tissue inflammation and VDR expression and methylation in colorectal cancer
Castellano-Castillo, Daniel; Morcillo Espina, Sonsoles; Clemente-Postigo, María Mercedes; Crujeiras Martínez, Ana Belén; Fernández-García, José Carlos; Torres Sánchez, Esperanza; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (BMC (Part of Springer Nature), 2018)Background: Lack of vitamin D (VD) has been associated with colorectal cancer (CRC). VD has anti-inflammatory effects and regulates several cellular pathways by means of its receptor, including epigenetic modifications. ... -
Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients
Clemente-Postigo, María Mercedes; Queipo-Ortuño, María Isabel; Valdivieso-Felices, Pedro; Tinahones-Madueño, Francisco José; Cardona-Díaz, Fernando (Elsevier. The Canadian Society of Clinical Chemists., 2010)Objectives: Apolipoprotein C-III (APOC3) is a component of triglyceride rich lipoproteins, and SstI polymorphism has been associated with hypertriglyceridemia. Apolipoprotein A-I (APOA1) is the major component of HDL and ... -
Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.
El-Bekay, Rajaa; Coín-Aragüez, Leticia I.; Fernandez-García, Diego; Oliva Olivera, Wilfredo; Bernal-López, María Rosa; Clemente-Postigo, María Mercedes; Delgado-Lista, Javier; Díaz-Ruiz, Alberto; Guzmán-Ruiz, Rocio; Vázquez-Martínez, Rafael; Lhamyani, Said; Roca-Rodríguez, María del Mar; Fernández-Veledo, Sonia; Vendrell, Joan; Malagón, Maria M.; Tinahones-Madueño, Francisco José[et al.] (British Pharmacological Society, 2016-03-18)Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, ... -
Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients
Clemente-Postigo, María Mercedes; Queipo-Ortuño, María Isabel; Murri, Mora; Boto-Ordóñez, María; Pérez-Martínez, Pablo; Andrés-Lacueva, Cristina; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (American Society for Biochemistry and Molecular Biology, 2012)The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, ... -
FABP4 Dynamics in Obesity: Discrepancies in Adipose Tissue and Liver Expression Regarding Circulating Plasma Levels
Queipo-Ortuño, María Isabel; Escoté Miró, Xavier; Ceperuelo-Mallafré, Victoria; Garrido-Sánchez, Lourdes; Miranda, Merce; Clemente-Postigo, María Mercedes; Pérez-Pérez, Rafael; Peral Fuentes, Belén; Cardona-Díaz, Fernando; Fernández Real, José M; Tinahones-Madueño, Francisco José; Vendrell Ortega, Joan[et al.] (PLOS (Public Library of Science), 2012)Background FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile. Objective In patients with a wide BMI range, we analyze FABP4 expression ... -
Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery
Clemente-Postigo, María Mercedes; Roca-Rodríguez, María del Mar; Camargo, Antonio; Ocaña-Wilhelmi, Luis Tomás; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (Elsevier (American Society for Metabolic and Bariatric Surgery), 2015)Background: Bariatric surgery usually results in metabolic improvements within a few days from intervention, but the underlying mechanism is not completely understood and may vary depending on the bariatric procedure. ... -
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity
Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Ramos-Molina, Bruno; Giráldez-Pérez, Rosa María; Lhamyani, Said; Alcaide Torres, Juan; Pérez-Martínez, Pablo; El Bekay Rizky, Rajaa; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (American Physiological Society, 2019)Impaired adipose tissue (AT) lipid handling and inflammation is associated with obesity-related metabolic diseases. Circulating lipopolysaccharides (LPSs) from gut microbiota (metabolic endotoxemia), proposed as a triggering ... -
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
Gentile, Adriana Mariel; Lhamyani, Said; Coín-Aragüez, Leticia I.; Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana Yanina; García Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez Silva, Francisco Javier; Murri, Mora; Tinahones-Madueño, Francisco José; El-Bekay, Rajaa[et al.] (Wiley, 2019)Objective: This study aimed to analyze the potential association of different microRNA (miRNA) moleculeswith both type 2 diabetes (T2D) and obesity and determine their target genes.Methods: Quantitative PCR was used to ... -
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
Clemente-Postigo, María Mercedes; Muñoz Garach, Araceli; Serrano, Marta; Garrido-Sánchez, Lourdes; Bernal-López, María Rosa; Fernandez-García, Diego; Moreno Santos, Inmaculada; Garriga, Nuria; Castellano-Castillo, Daniel; Camargo, Antonio; Fernández Real, José M; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Endocrine Society, 2015)Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be ...