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Listar por autor "Bravo-Romero, María José"
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A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer’s Disease
Esteban-Martos, Alvaro; Brokate-Llanos, Ana María; Real-Navarrete, Luis Miguel; Melgar-Locatelli, Sonia; De Rojas, Itziar; Castro-Zavala, Adriana; Bravo-Romero, María José
; Mañas-Padilla, María del Carmen; García-González, Pablo; Ruiz-Galdón, Maximiliano
; Pacheco-Sánchez, Beatriz; Polvillo, Rocío; Rodriguez-de-Fonseca, Fernando; González, Irene; Castilla-Ortega, María Estela
; Muñoz-Gómez, Manuel
; Rivera, Patricia; Reyes-Engel, Armando
; Ruiz, Agustín; Royo-Sánchez-Palencia, José Luis
[et al.] (MDPI, 2023)
Genome-wide association studies (GWAS) constitute a powerful tool to identify the different biochemical pathways associated with disease. This knowledge can be used to prioritize drugs targeting these routes, paving the ... -
A metagenome-wide association study of HIV disease progression in HIV controllers.
Real-Navarrete, Luis Miguel; Saéz, María E; Corma-Gómez, Anaïs; González-Pérez, Antonio; Thorball, Christian; Ruiz, Rocío; Jiménez-León, María Reyes; González-Serna, Alejandro; Gasca-Capote, Carmen; Bravo-Romero, María José
; Royo-Sánchez-Palencia, José Luis
; Pérez-Gómez, Alberto; Camacho-Sojo, María Inés; Gallego, Isabel; Joana, Vitalle; Bachiller, Sara; Gutierrez-Valencia, Alicia; Vidal, Francisco; Fellay, Jacques; Lichterfeld, Mathias; Ruiz-Mateos, Ezequiel[et al.] (Elsevier, 2023)
Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 ... -
Comparative Clinical Study of Different Multiplex Real Time PCR Strategies for the Simultaneous Differential Diagnosis between Extrapulmonary Tuberculosis and Focal Complications of Brucellosis.
Sanjuan-Jimenez, Rocio; Morata-Losa, María Pilar; Bermúdez, Pilar; Bravo-Romero, María José
; Colmenero Castillo, Juan de Dios (PLOS, 2013-12-12)
Background Both brucellosis and tuberculosis are chronic-debilitating systemic granulomatous diseases with a high incidence in many countries in Africa, Central and South America, the Middle East and the Indian subcontinent. ... -
Quantitative real-time polymerase chain reaction improves conventional microbiological diagnosis in an outbreak of brucellosis due to ingestion of unpasteurized goat cheese.
Colmenero Castillo, Juan de Dios; Clavijo-Frutos, Encarnación; Morata-Losa, María Pilar
; Bravo-Romero, María José
; Queipo-Ortuño, María Isabel
(Elsevier, 2011-11)
Rapid diagnosis of individuals involved in brucellosis outbreaks can sometimes be difficult with conventional microbiological techniques. We analyzed, for the first time, the diagnostic yield of a real-time polymerase chain ... -
The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study).
Martín-Sierra, Carmen; Bravo-Romero, María José; Saez, Maria Eugenia; De Rojas, Itziar; Santos, Marta; Martín-Carmona, Jesica; Corma-Gómez, Anaïs; González-Serna, Alejandro; Royo-Sánchez-Palencia, José Luis
; Pineda, Juan A.; Rivero, Antonio; Rivero-Juárez, Antonio; Macías, Juan; Real-Navarrete, Luis Miguel
[et al.] (Elsevier, 2024)
Background & aims It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and ... -
The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective.
Burgos-Molina, Antonio Manuel; Téllez-Santana, Teresa
; Redondo-Bautista, Maximino
; Bravo-Romero, María José
(MDPI, 2024)
Chronic inflammation drives the growth of colorectal cancer through the dysregulation of molecular pathways within the immune system. Infiltration of immune cells, such as macrophages, into tumoral regions results in the ... -
Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
Laplana, Marina; Bravo-Romero, María José; Fernández-Fuertes, Marta; Ruiz-García, Celia; Alarcón-Martín, Emilio; Colmenero Castillo, Juan de Dios; Caruz-Arcos, Antonio; Fibla, Joan; Real-Navarrete, Luis Miguel
; Royo-Sánchez-Palencia, José Luis
[et al.] (Oxford Academy, 2020)
Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its ... -
Unlocking New Avenues in Breast Cancer Treatment: The Synergy of Kinase Inhibitors and Immunotherapy
Bravo-Romero, María José; Burgos-Molina, Antonio Manuel
; García Aranda, Marilina; Redondo-Bautista, Maximino
; Téllez-Santana, Teresa
(MDPI, 2023)
Cancer is one of the world’s most significant health problems today. Currently, breast cancer has globally surpassed lung cancer as the most commonly diagnosed cancer in women. In 2020, an estimated 2,261,419 new cases ...