Listar por autor "García-León, Juan Antonio"
Mostrando ítems 1-20 de 31
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Animal and cellular models of Alzheimer’s disease: Progress, promise, and future approaches.
Trujillo-Estrada, Laura Isabel
; Sánchez-Mejías, Elisabeth; Sánchez-Varo, Raquel María; García-León, Juan Antonio; Nuñez-Diaz, Cristina; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; LaFerla, Frank; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (SAGE, 2022-12-06)
Alzheimer’s disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms ... -
Co-cultures between neurons and astrocytes to address Alzheimer´s disease pathology.
Cáceres Palomo, Laura; García-León, Juan Antonio; Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Dataset seeding paper JAL.
Andreo-López, Juana; Núñez-Díaz, Cristina; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Da Cunha, Celia; Cantero-Molina, Francisco; Campos-Moreno, Cynthia; Zimbone, Stefania; Bellia, Francesco; Giuffrida, Maria Laura; Trujillo-Estrada, Laura Isabel; García-León, Juan Antonio; Bettinetti-Luque, Miriam; Gámez, Nazaret; Valdés, Catalina; Morales, Rodrigo; Forner, Stefania; Martini, Alessandra C.; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (Universidad de Málaga, 2023-11-24)
Este trabajo se centra en el estudio de la propagación de la patología amiloidea en diferentes modelos animales para la Enfermedad de Alzheimer (EA). Los resultados sugieren que existen diversos factores que modulan este ... -
Desarrollo de precursores neurales, astrocitos y microglía derivados de células madre pluripotentes inducidas (iPSCs) humanas como modelos celulares para el estudio de la enfermedad de Alzheimer.
(UMA Editorial, 2025)La enfermedad de Alzheimer (AD) es la principal causa de demencia y la patología neurodegenerativa más prevalente en el mundo. Afecta a la población mayor de 65 años y se proyecta un aumento significativo debido al ... -
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Mejías-Ortega, Marina; Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2020-03)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ... -
Fast and efficient generation of oligodendrocytes from human induced pluripotent stem cells (hiPSCs)
García-León, Juan Antonio; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Verfaillie, Catherine M.; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2021-07)
Oligodendrocytes (OLs) are highly specialized cells of the central nervous system responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including ... -
Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Pinto-Medel, Maria Jesús; Mayorga Mayorga, Cristobalina; García-León, Juan Antonio; Maldonado-Sanchez, Rafael; Suardíaz García, Margarita; Guerrero, Miguel; Luque, Gloria; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (Elsevier, 2011)
IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged ... -
Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration
García-León, Juan Antonio; Cabrera-Socorro, Alfredo; Eggermont, Kristel; Swijsen, Ann; Terryn, Joke; Fazal, Raheem; Nami, FatemehArefeh; Ordovás, Laura; Quiles, Ana; Lluis, Frederic; Serneels, Lutgarde; Wierda, Keimpe; Sierksma, Annerieke; Kreir, Mohamed; Pestana, Francisco; Van Damme, Philip; De Strooper, Bart; Thorrez, Lieven; Ebneth, Andreas; Verfaillie, Catherine M[et al.] (Wiley, 2018-10)
Introduction Tauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but ... -
Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.
Baglietto-Vargas, David; Forner, Stefania; Cai, Lena; Martini, Alessandra C; Trujillo-Estrada, Laura; Swarup, Vivek; Minh Thu Nguyen, Marie; Do Huynh, Kelly; Javonillo, Dominic I; Minh Tran, Kristine; Phan, Jimmy; Jiang, Shan; Kramár, Enikö A; Nuñez-Diaz, Cristina; Balderrama-Gutierrez, Gabriela; Garcia, Franklin; Childs, Jessica; Rodriguez-Ortiz, Carlos J; Garcia-Leon, Juan Antonio; Kitazawa, Masashi; Shahnawaz, Mohammad; Matheos, Dina P; Ma, Xinyi; Da Cunha, Celia; Walls, Ken C; Ager, Rahasson R; Soto, Claudio; Gutierrez, Antonia; Moreno-Gonzalez, Ines; Mortazavi, Ali; Tenner, Andrea J; MacGregor, Grant R; Wood, Marcelo; Green, Kim N; LaFerla, Frank M[et al.] (Springer Nature, 2021-04-23)
The majority of Alzheimer’s disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant ... -
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells
García-León, Juan Antonio; Garcia Diaz, Beatriz; Eggermont, Kristel; Cáceres Palomo, Laura; Neyrinck, Katrien; Madeiro da Costa, Rodrigo; Dávila-Cansino, José Carlos; Baron Van Evercooren, Anne; Gutiérrez-Pérez, Antonia; Verfaille, Catherine M[et al.] (Springer Nature, 2020)
Oligodendrocytes (OLs) are responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including multiple sclerosis (MS) and amyotrophic lateral ... -
Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics.
Szabo, Leonora; Grimm, Amandine; García-León, Juan Antonio; Verfaillie, Catherine M.; Eckert, Anne (MDPI, 2023-05-13)
Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have been identified in the tau-encoding gene MAPT, affecting either ... -
Glia and neurons from human iPSCs to address the pathology of Alzheimer´s disease
García-León, Juan Antonio; Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling
Cáceres Palomo, Laura; López Oliva, Elba; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; García-León, Juan Antonio[et al.] (2022)
Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal ... -
Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease.
García-León, Juan Antonio; Cáceres Palomo, Laura; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Núñez-Díaz, Cristina; Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (MDPI, 2020-09-18)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still not fully understood, since different ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
García-León, Juan Antonio; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia (2020-12-18)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
Alcina, Antonio; Fedetz, María; Fernández, Óscar; Saiz, Albert; Izquierdo, Guillermo; Lucas, Miguel; Leyva-Fernández, Laura; García-León, Juan Antonio; Abad-Grau, María del Mar; Alloza, Iraide; Antigüedad, Alfredo; Garcia-Barcina, María Jesús; Vandenbroeck, Koen; Varadé, Jezabel; de la Hera, Belén; Arroyo, Rafael; Comabella, Manuel; Montalban, Xavier; Petit-Marty, Natalia; Navarro, Arcadi; Otaegui, David; Olascoaga, Javier; Blanco, Yolanda; Urcelay, Elena; Matesanz, Fuencisla[et al.] (BMJ Journals, 2013-01)
Background and aim: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants ... -
In vitro modeling of dysfunctional glial cells in neurodegenerative diseases using human pluripotent stem cells
García-León, Juan Antonio; Eggermont, K; Neyrinck, K; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Verfaillie, Catherine M.; Gutiérrez-Pérez, Antonia[et al.] (2019-07-26)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable models, have precluded the development of effective therapies counteracting ... -
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients
García-León, Juan Antonio; Pinto-Medel, Mª Jesús; García-Trujillo, Lucía; López-Gómez, Carlos; Oliver-Martos, Begoña; Prat-Arrojo, Isidro; Marín-Bañasco, Carmen; Suardíaz-García, Margarita; Maldonado-Sánchez, Rafael; Fernández Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Elsevier, 2011)
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients.
García-León, Juan Antonio; Pinto-Medel, María-Jesús; García-Trujillo, Lucía; López-Gómez, Carlos; Oliver-Martos, Begoña; Prat-Arrojo, Isidro; Marín-Bañasco, Carmen; Suardíaz-García, Margarita; Maldonado-Sánchez, Rafael; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Elsevier, 2011-09)
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response
García-León, Juan Antonio; López-Gómez, Carlos; Orpez-Zafra, Teresa; Reyes-Garrido, Virginia; Marín Bañasco, Carmen; Oliver-Martos, Begoña; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Springer Link, 2014)
Background: Both the adaptative and the innate immune systems interplay in multiple sclerosis (MS) pathogeny. Killer-cell immunoglobulin-like receptors (KIRs) are key regulators of the immune response, with activating and ...