Listar por autor "García-León, Juan Antonio"
Mostrando ítems 1-10 de 10
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Co-cultures between neurons and astrocytes to address Alzheimer´s disease pathology.
Cáceres Palomo, Laura; García-León, Juan Antonio
; Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Fast and efficient generation of oligodendrocytes from human induced pluripotent stem cells (hiPSCs)
García-León, Juan Antonio; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Verfaillie, Catherine M.; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2021-07)
Oligodendrocytes (OLs) are highly specialized cells of the central nervous system responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including ... -
Genetically Engineered Triple MAPT-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics.
Szabo, Leonora; Grimm, Amandine; García-León, Juan Antonio; Verfaillie, Catherine M.; Eckert, Anne (MDPI, 2023-05-13)
Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have been identified in the tau-encoding gene MAPT, affecting either ... -
Glia and neurons from human iPSCs to address the pathology of Alzheimer´s disease
García-León, Juan Antonio; Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling
Cáceres Palomo, Laura; López Oliva, Elba; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; García-León, Juan Antonio[et al.] (2022)
Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
García-León, Juan Antonio; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia (2020-12-18)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
In vitro modeling of dysfunctional glial cells in neurodegenerative diseases using human pluripotent stem cells
García-León, Juan Antonio; Eggermont, K; Neyrinck, K; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Verfaillie, Catherine M.; Gutiérrez-Pérez, Antonia[et al.] (2019-07-26)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable models, have precluded the development of effective therapies counteracting ... -
Neurons and astrocytes derived from human iPSCs to model Alzheimer´s disease
Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia; García-León, Juan Antonio[et al.] (2023)
Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, several ... -
Suitability of human-derived cells as a platform for Alzheimer's disease modeling
Cáceres Palomo, Laura; García-León, Juan Antonio; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia (2021)
Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ...