Listar por autor "Mayorga Mayorga, Cristobalina"
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Advances and highlights in T and B cell responses to drug antigens
Fernández-Santamaría, Rubén; Ariza Veguillas, Adriana; Fernández-Duarte, Tahía Diana
; Céspedes Lagos, José Antonio; Labella, Marina; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (Wiley, 2021-10-07)
The immunological mechanisms involved in drug hypersensitivity reactions (DHRs) are complex, and despite important advances, multiple aspects remain poorly understood. These not fully known aspects are mainly related to ... -
Allergen exposure boosts peripheral Th9 responses in patients with local allergic rhinitis
Palomares, Francisca; Aranda, Carlos José; Saenz de Santa María-García, Rocío; Mayorga Mayorga, Cristobalina; Rondón Segovia, Carmen; Testera Montes, Almudena; Alba-Linero, Carmen; Bentabol-Ramos, Guillermo; Torres-Jaén, María Josefa; Eguiluz-Gracia, Ibón[et al.] (Wiley, 2023)
Key points ∙ Intranasal allergen exposure increases peripheral total Th2 and Th9 cells in patients with local allergic rhinitis (LAR). ∙ Peripheral T-cell response seems dominated by Th9 cells in patients with LAR, ... -
Basophil activation test positivity decreases with time in immediate allergic reactions to proton pump inhibitors
Fernández-Santamaría, Rubén; Salas, Maria; Ariza Veguillas, Adriana; Jiménez, María A.; González-Mendiola, María R.; Sánchez, María L.; Boteanu, Cosmin; Mayorga Mayorga, Cristobalina; Fernández-Duarte, Tahía Diana; Torres, María José; Laguna, José J.[et al.] (Wiley, 2024-11-27)
Omeprazole is a widely prescribed proton pump inhibitor [1], with 1%–3% of adverse reactions being reported. Up to 86% of these reactions are IgE mediated [2] and half of them anaphylaxis [1]. An accurate diagnosis is ... -
Basophil Activation Test Utility as a Diagnostic Tool in LTP Allergy
Cañas, José Antonio; Pérez-Sánchez, Natalia Isabel; Palomares, Francisca; Molina, Ana; Bartra, Joan; Torres-Jaén, María Josefa; Gómez, Francisca; Mayorga Mayorga, Cristobalina[et al.] (IOAP-MPDI, 2022-04-29)
Plant-food allergy is an increasing problem, with nonspecific lipid transfer proteins (nsLTPs) triggering mild/severe reactions. Pru p 3 is the major sensitizer in LTP food allergy (FA). However, in vivo and in vitro ... -
Biomarkers of immediate drug hypersensitivity
Mayorga Mayorga, Cristobalina; Ariza, Adriana; Muñoz-Cano, Rosa; Sabato, Vito; Doña, Inmaculada; Torres-Jaén, María Josefa[et al.] (Wiley, 2023-11-10)
Immediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic ... -
Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests.
Torres-Jaén, María Josefa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; Guzmán, Antonio-Eloy; Cornejo García, José Antonio; Juárez, Carlos; Blanca, Miguel[et al.] (Wiley, 2002)
Although subjects with a positive history of immediate allergy to penicillin and negative skin test are considered to tolerate penicillin, they may develop an immediate reaction despite negative skin and serum specific IgE ... -
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity.
Posadas, Sinforiano Jose; Padial, Antonia; Torres-Jaén, María Josefa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; Sánchez, Elena; Álvarez, Javier; Romano, Antonino; Juárez, Carlos; Blanca, Miguel; Sánchez, Elena[et al.] (Elsevier, 2002)
Background Drugs can induce different immunologic reactions; T-cell mediated responses produce the most severe reactions. Although in vitro studies show that T cells recognize drugs or their metabolites and induce an ... -
Dendrímeros antigénicos sobre partículas de sílica para determinar IgE específicas de antibióticos betalactámicos
Matamoros Castellano, Esther; Jiménez, Isabel M.; Gil-Ocaña, Violeta; Mayorga Mayorga, Cristobalina; Doña, Inmaculada; Céspedes Lagos, José Antonio; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Torres-Cazorla, María Isabel[et al.] (2022)
Los inmunoensayos empleados para el diagnóstico in vitro de alergias a antibióticos betalactámicos actualmente presentan una limitada sensibilidad y pobre especificidad, además de no estar disponibles de forma comercial ... -
Design of multi-haptenized dendrimeric-antigens for in vitro IgE recognition
Nájera-Albendín, Francisco; Montañez-Vega, María Isabel; Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda; Collado-Martín, Daniel; Pérez-de-Inestrosa-Villatoro, Ezequiel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Blanca Gómez, Miguel[et al.] (2014-06-12)
Reactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, ... -
Detection of Serum-Specific IgE by Fluoro-Enzyme Immunoassay for Diagnosing Type I Hypersensitivity Reactions to Penicillins
Ariza Veguillas, Adriana; Mayorga Mayorga, Cristobalina; Bogas Herrera, Gádor; Gaeta, Francesco; Salas, María; Valluzzi, Rocco Luigi; Labella, Marina; Pérez-Sánchez, Natalia Isabel; Caruso, Cristiano; Molina, Ana; Fernández-Duarte, Tahía Diana; Torres-Jaén, María Josefa; Romano, Antonino[et al.] (IOAP-MPDI, 2022-06-23)
Diagnosis of type I hypersensitivity reactions (IgE-mediated reactions) to penicillins is based on clinical history, skin tests (STs), and drug provocation tests (DPTs). Among in vitro complementary tests, the fluoro-enzyme ... -
Diagnosis and Treatment in Asthma and Allergic Rhinitis: Past, Present, and Future
Espada-Sánchez, Marta; Saenz de Santa María-García, Rocío; Martín Astorga, María del Carmen; Lebrón-Martín, Clara; Romero-Delgado, María-Jesús; Eguiluz-Gracia, Ibón; Rondón Segovia, Carmen; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Aranda, Carlos José; Cañas, José Antonio[et al.] (IOAP-MDPI, 2023-01-18)
Respiratory diseases are pathological conditions that affect airways, hampering breathing and causing high mortality. In particular, asthma and allergic rhinitis (AR) are two of the most common airway diseases that affect ... -
Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study
Céspedes Lagos, José Antonio; Fernández-Santamaría, Rubén; Ariza Veguillas, Adriana; Bogas Herrera, Gádor; Doña, Inmaculada; Rondón, Carmen; Salas, María; Labella, Marina; Frecha, Cecilia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (Wiley, 2022-12-07)
Amoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high-risk ... -
Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose
Ruiz-Sanchez, Antonio Jesus; Collado-Martín, Daniel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Pérez-de-Inestrosa-Villatoro, Ezequiel (2020-10-01)
β-lactams are the most widely drug prescribed against infections, but they are the most commonly reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid rejecting them by other ... -
DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain.
Fernández-Fernández, Óscar; Fernández, Victoria; Alonso, Antonio; Caballero-González, Abelardo; Luque, Gloria; Bravo, Mariano; León-Martín, Antonio; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; De Ramón Garrido, Enrique[et al.] (Springer, 2004-04)
Background The human leukocyte antigen (HLA) class II DR2 haplotype (DRB1*1501, DQA1*0102, DQB1*0602) has been associated with multiple sclerosis (MS) in all ethnic groups and very strongly in Caucasians. Aim To investigate ... -
Estudio de los mecanismos inmunológicos implicados en la inmunoterapia específica con alérgenos. Papel de las células T reguladoras y efectoras específicas
(UMA Editorial, 2018)Dentro de las reacciones alérgicas originadas en las vías respiratorias, la rinitis alérgica (RA) es la que cobra mayor importancia en cuanto a su incidencia en la población. Entre los alérgenos más prevalentes en esta ... -
Estudios de la modulación de la respuesta inmunológica y desarrollo de modelos de tolerancia a alérgenos de origen vegetal utilizando nanoestructuras polifuncionales
(UMA Editorial, 2020)La alergia a alimentos es en la actualidad un problema de salud grave, ya que produce reacciones que pueden comprometer la vida del paciente. Su prevalencia va en aumento, llegando a afectar al 3-5% de la población adulta ... -
Estudios ómicos de la respuesta de tolerancia inducida tras inmunoterapia específica de alérgeno en un modelo de anafilaxia a melocotón.
(UMA Editorial, 2024)En la actualidad la alergia a alimentos es una patología en auge, un 3,28% de la población adulta española es alérgica a algún alimento, la mayor parte a alimentos de origen vegetal. De entre los alérgenos de origen vegetal ... -
Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions
Blanca, Miguel; Posadas, Sinforiano Jose; Torres-Jaén, María Josefa; Leyva-Fernández, Laura; Mayorga Mayorga, Cristobalina; González, Lourdes; Juárez, Carlos; Fernández, Javier; Santamaría, Luis F[et al.] (Wiley, 2000)
Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T lymphocytes may play a relevant role. T cells related to skin immune responses express the cutaneous ... -
Flow-based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper
Mayorga Mayorga, Cristobalina; Çelik, G.E.; Pascal, M.; Hoffmann, H.J.; Eberlein, B.; Torres-Jaén, María Josefa; Brockow, K.; Garvey, L.H.; Barbaud, A.; Madrigal-Burgaleta, R.; Caubet, J.C.; Ebo, D.G.[et al.] (Wiley, 2023-11-13)
Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in ... -
Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Pinto-Medel, Maria Jesús; Mayorga Mayorga, Cristobalina; García-León, Juan Antonio; Maldonado-Sanchez, Rafael; Suardíaz García, Margarita; Guerrero, Miguel; Luque, Gloria; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (Elsevier, 2011)
IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged ...