Listar por autor "Martinez-Poveda, Beatriz Amparo"
Mostrando ítems 1-20 de 35
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(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martinez-Poveda, Beatriz Amparo
; Rodriguez-Quesada, Ana Maria; Medina Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo
Carrillo Fernández, Paloma; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria (2016-10-03)
Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ... -
Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
Bravo-Ruiz, Inés; Bernal, Manuel; Manrique-Poyato, Maria Inmaculada; Rodriguez-Quesada, Ana Maria; Medina Torres, Miguel Ángel; Castilla, Laura; Martinez-Poveda, Beatriz Amparo[et al.] (43 Congreso Anual SEBBM, 2021)
Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Sarabia-Garcia, Francisco Ramon; Rodriguez-Quesada, Ana Maria[et al.] (2017-11-09)
In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Búsqueda y caracterización de nuevos candidatos a fármacos inhibidores de la angiogénesis
(Uma Editorial, 2019-10)La presente Tesis Doctoral se ha realizado en el grupo de investigación dedicado a la búsqueda y caracterización de nuevos fármacos antiangiogénicos del Departamento de Biología Molecular y Bioquímica de la Universidad de ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Martinez-Poveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
El análogo de las estrigolactonas GR-24 induce cambios en el citoesqueleto de células tumorales y endoteliales y modula su balance rédox
Torres-Vargas, José Antonio; Martinez-Poveda, Beatriz Amparo; Carrillo Fernández, Paloma; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria (2018-12-12)
Las estrigolactonas son hormonas vegetales con estructura terpenoide, implicadas en el control de una serie de procesos que incluyen la inhibición de la ramificación de la raíz y el brote. Recientemente, se ha descrito el ... -
Estudios de preferencia metabólica en células del “microambiente angiogénico”
Ocaña, Mª Carmen; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (2016-10-03)
El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina, Miguel Ángel; Ocaña-Ocaña, Maria del Carmen; Martinez-Poveda, Beatriz Amparo; Carrillo Fernández, Paloma; Urdiales-Ruiz, Jose Luis; Serrano, José J.; Montañez, Raúl; Rodriguez-Quesada, Ana Maria[et al.] (2017-08-29)
The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives
Marrero, Ana Dácil; Martinez-Poveda, Beatriz Amparo; Castillo, Laura; Gallardo, Elena; Espartero, José L.; Carrillo Fernández, Paloma; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel[et al.] (2018-09-19)
Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Carrillo Fernández, Paloma; Rodriguez-Quesada, Ana Maria; López-Romero, Juan Manuel; Sarabia-Garcia, Francisco Ramon[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis
Ocaña, Mª Carmen; Carrillo Fernández, Paloma; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (2017-10-31)
The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ... -
Gastronomía Bioactiva: compuestos bioactivos en alimentos y quimioprevención en enfermedades de alta prevalencia
Martinez-Poveda, Beatriz Amparo; Marrero Capitán, Ana Dácil; Rodriguez-Quesada, Ana Maria; Medina Torres, Miguel Ángel (43 Congreso Anual SEBBM, 2021)
La quimioprevención de enfermedades basada en la dieta ha surgido en los últimos años como un enfoque interesante para la prevención, e incluso la ralentización de fases iniciales, en patologías de alta prevalencia como ... -
Identification and characterization of new anti-angiogenic compounds from natural sources
Carrillo Fernández, Paloma; Ocaña, Mª Carmen; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria (2017-07-21)
The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ... -
Interplay between glucose and palmitate uptake in breast carcinoma in vitro
Ocaña, Mª Carmen; Carrillo Fernández, Paloma; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (2018-07-17)
One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important ... -
La enseñanza del metabolismo: retos y oportunidades
Medina, Miguel Ángel; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José; Valpuesta-Fernandez, Victoriano; Heredia-Bayona, Antonio; Salto-González, Rafael; Vílchez-Rienda, José Dámaso; Girón González, María Dolores; Morata-Losa, Maria Pilar; Urdiales-Ruiz, Jose Luis; Fajardo-Paredes, Ignacio José; García Ponce, Ángel Luis; Torres, Néstor; Santos, Guido; Herráez, Ángel; Roca-Salom, Pilar; Sastre-Serra, Jorge; Oliver, Jordi; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Navas-Delgado, Ismael; García-Godoy, Maria Jesús; López-Camacho, Esteban; Rybinski, Maciej; Aldana-Montes, José Francisco; Rodrígue-Caso, Carlos; Perez-Rodriguez, Josefa; Blanco-Lopez, Angel[et al.] (2017-12)
Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos ... -
Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?
Ocaña-Ocaña, Maria del Carmen; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (2019-04-24)
Metabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as ... -
Learning contract, co-operative and flipped learning as useful tools for studying metabolism
Martinez-Poveda, Beatriz Amparo; García Ponce, Ángel Luis; Blanco-Lopez, Angel; Rodriguez-Quesada, Ana Maria; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José; Medina, Miguel Ángel[et al.] (2018-06-25)
Undergraduate students in Biology identify Metabolic Biochemistry as a particularly difficult subject. This is due to the fact that students need to interconnect properly all the contents of its syllabus throughout their ... -
Libro de actas del Workshop Internacional Metabolic Reprogramming as a Target for Cancer and Other Diseases
Este libro sobre el Workshop Internacional Metabolic Reprogramming as a Target for Cancer and Other Diseases se ha publicado con el apoyo económico de los fondos para difusión y divulgación del Proyecto del Plan Estatal ... -
Marine sponge as a source of antiangiogenic compounds. The case of aeroplysinin-1
Rodriguez-Quesada, Ana Maria; Martinez-Poveda, Beatriz Amparo; Rodríguez-Nieto, S; Medina, Miguel Ángel (2014-04-02)
The vast majority of the natural compounds that have been previously described as inhibitors of angiogenesis have been isolated from plants and terrestrial microorganisms, mainly due to their higher availability and because ...