Listar por autor "Mercado-Sáenz, Silvia"
Mostrando ítems 1-19 de 19
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Acquisition resistance to bleomycin deregulates HSP77 and HSP60 proteins in response to stress
Burgos-Molina, Antonio Manuel
; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
The HSP77 and HSP60 protein overexpression is implicated in bleomycin resistance. The resistant adquisition to antineoplastic drugs deregulate proteins involved in response to stress factors. -
Beneficial interactions between the microbiota and the host increase immunity for a better response to treatment of cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
Numerous beneficial interactions between microbiota and host contribute to produce nutrients, metabolites, immunoglobulins and an increase in lymphocytes. The correct colonization of the intestine by microbiota induces a ... -
Case study of the intestinal microbiota using the XGN-MBI metagenomic assay
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Morales-Moreno, Francisco; Ruiz-Gómez, Miguel José (2019-01-17)
The microbiota of the colon and rectum is the most abundant and diverse of the human body, with a density of up to 1-2 kg of weight and a diversity that exceeds a thousand species. Metagenomics can be defined as the ... -
Cellular microenvironment can be modulated by factors influenced by microbiota to improve cancer treatment
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
Numerous environmental factors affect the ecosystem of the microbiota, so its composition and diversity can be modified by changes produced in these factors. These alterations can facilitate the appearance of pathological ... -
Clinical metagenomic analysis and Cancer
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Morales Moreno, Francisco; González Vidal, Alejandro; Ruiz-Gómez, Miguel José (Aseica, 2022)
After seven years of periodic controls by the SEIMC (Spanish Society of Infectious Diseases and Clinical Microbiology), it can be affirmed that the analysis is capable of detecting microorganisms in any type of sample ... -
Gastrointestinal cancer: Relationship between histology and microbiota
García Sanz, A; Escamilla-Sanchez, Alejandro; Mercado-Sáenz, Silvia; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Sánchez-Varo, Raquel María; Peláez-González, Alberto Carlos; López-Villodres, Juan Antonio; Bermúdez-Flores, Diego Teófilo[et al.] (2022-09-09)
Objectives: Review of the published literature concerning the relationship between microbiome and gastrointestinal cancer. Methods: Present work is focused on systematic research in the most prominent biomedical databases ... -
Gastrointestinal Stromal Tumor (GIST) and its relationship with germline mutations
Arranz-Salas, Isabel María; Jiménez-Campillo, Marta; Hierro-Martín, María Isabel; Ortega-Jiménez, María Victoria; Mercado-Sáenz, Silvia; Rodríguez-Pérez, Luis Manuel; Sánchez-Varo, Raquel María; Escamilla-Sanchez, Alejandro; Peláez-González, Alberto Carlos; Bermúdez-Flores, Diego Teófilo[et al.] (2022)
We present the case of a 38-year-old man with a history of abdominal paraganglioma 10 years ago, who consulted for hematemesis and asthenia of 5 days' evolution. An upper gastrointestinal endoscopy was performed where a ... -
Intestinal microbiota and colorectal cancer
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Morales-Moreno, Francisco; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-16)
Colorectal cancer may be influenced by changes in the intestinal microbiota that affect the mucosa and cause an immune response capable of producing inflammatory effects. Although there are still few studies in this regard, ... -
Methods to study the intestinal microbiota to address the disease in a more precise and personalized way
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Mercado-Sáenz, Silvia; Alamilla Presuel, Juan Carlos; Ruiz-Gómez, Miguel José (2022)
FISH, clone collection, DGGE, PCR and metagenomics techniques contribute to the study of the human microbiota in a precise and effective way, constituting very useful diagnostic tools in precision medicine to address patient ... -
Microbiota and body axes as a new therapeutic approach in precision medicine
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
There is a marked relationship between the composition and diversity of the microbiota and various diseases distant from the intestine. This relationship occurs through different body axes between the intestine and the ... -
Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity.
González Vidal, Alejandro; Mercado-Sáenz, Silvia; Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Alcaraz, Miguel; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (MDPI, 2023-08-30)
The repair of the damage produced to the genome and proteome by the action of ionizing radiation, oxidizing agents, and during aging is important to maintain cellular homeostasis. Many of the metabolic pathways influence ... -
Oligodendrocyte metabolism throughout its differentiation: immunocytochemistry study and its impact in remyelination
Gismero Rodríguez, Javier; López-Villodres, Juan Antonio; Escamilla-Sanchez, Alejandro; García Díaz, Beatriz; Rodríguez-Pérez, Luis Manuel; Mercado-Sáenz, Silvia; Ortega-Jiménez, María Victoria; Arranz-Salas, Isabel María; Peláez-González, Alberto Carlos; Bermúdez-Flores, Diego Teófilo[et al.] (2022-09-07)
Introduction: Oligodendrocytes (OL) role in demyelinating pathologies such as multiple sclerosis and other neurodegenerative diseases is only recently being subject of extensive research. While the genetic and molecular ... -
Protein homeostasis as a therapeutical target for Alzheimer’s disease: analysis in the hippocampus of transgenic mouse models
Sánchez-Varo, Raquel María; Criado-Álamo, Elena; Fernández-Valenzuela, Juan José; Mercado-Sáenz, Silvia; López-Villodres, Juan Antonio; Escamilla-Sanchez, Alejandro; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Ortega-Jiménez, Concepción; Alba-Tercedor, Carmen; Gutiérrez-Pérez, Antonia[et al.] (2022-09)
Alzheimer's disease (AD) constitutes the most prevalent form of dementia. There is no cure so there is an urgent need of novel therapeutic targets and treatments. The main histopathological hallmarks of AD brains are ... -
Proteins involved in carbon metabolism induce bleomycin resistance
Burgos-Molina, Antonio Manuel; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; González Vidal, Alejandro; Ruiz González, Óscar M.; Ruiz-Gómez, Miguel José[et al.] (Aseica, 2022)
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes overexpression of TPIS protein. It could be involved in the resistance process. For this reason, it could be good candidates ... -
Pulsed magnetic feld increases the efect of ultraviolet C radiation and thermal shock in aged yeasts
Mercado-Sáenz, Silvia; González-Vidal, Alejandro; Burgos-Molina, Antonio Manuel; López-Díaz, Beatriz; Sendra-Portero, Francisco; Ruiz-Gómez, Miguel José[et al.] (Springer, 2023)
The study of the efects of the magnetic feld (MF) on living matter continues to be a dilemma. Until now, the interaction mechanisms of MF with living matter that explain the observed phenomena are unknown. Despite the ... -
Relationship between chronological aging and acquired resistance to cisplatin in the yeast saccharomyces cerevisiae
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-17)
The Sir2 gene is associated with an increase in longevity in yeasts, worms, flies and rodents. The human homolog, Sirt1, is also involved in longevity, by inhibiting cellular senescence. Studies carry out in tumor cells ... -
Resistance to bleomycin increases the chronological life of cells
Burgos-Molina, Antonio Manuel; Mercado-Sáenz, Silvia; Gil-Carmona, Luisa; Ruiz-Gómez, Miguel José (2019-01-17)
The identification of genes involved in chronological aging could have a potential utility as molecular markers in the chemotherapy treatment of cancer. The aim of this work is to study the relationship between the ... -
The absence of microbiota dysbiosis is essential to maintain a healthy immune system in cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
Gut microbiota is required for mucosal immunity. The intestinal mucosa is the main location for microbiome-host interactions. The dynamic interaction between microbiome and environmental factors modulate mucosal and systemic ... -
The relationship between SARS-Cov2 infection and microbiota is of special interest in cancer patients
Burgos-Molina, Antonio Manuel; González Vidal, Alejandro; Alamilla Presuel, Juan Carlos; Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José (2022)
SARS-Cov2 can produce an imbalance in the diversity of microbiota leading to different symptoms and affecting the health and response of cancer patients to treatment. Therefore, it is important to further investigate in ...