Listar por autor "Millón-Peñuela"
Mostrando ítems 1-20 de 64
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A new pharmacological strategy against treatment-resistant depression
Pineda-Gomez, Juan Pedro; Millón-Peñuela, Carmelo
; Cantero García, Noelia; Flores, Marta; Ladrón de Guevara-Miranda, David; Flores-Burgess, Antonio; Díaz-Cabiale, Zaida[et al.] (Elsevier, 2024)
Major depressive disorder affects more than 50 million people in the world. However, 50% of patients don’t respond to two or more drugs or psychotherapeutic treatments, named treatment-resistant depression (TRD). In this ... -
A Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been ... -
A Role for Galanin N-Terminal Fragment (1–15) in Anxiety- and Depression-Related Behaviors in Rats.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narvaez, Jose Angel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (Oxford Academic, 2015-02-16)
Galanin (GAL) plays a role in mood regulation. In this study we analyzed the action of the active N-terminal fragment [GAL(1–15)] in anxiety- and depression-related behavioral tests in rats. Methods: The effect of ... -
Aggressive behavior of Merkel cell carcinoma of the skin may be related to tumor microvasculature density
Parrado-Romero, Concepción; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Narváez-Bueno, José Ángel; Rios, Maria del Carmen; Navarro, Luis; Díaz-Cabiale, Zaida[et al.] (2014-06-18)
First primary MCC is a disease of elderly people. It is only sporadically reported before age 50; then, its overall age-adjusted incidence rate starts increasing gradually, from age 50 to age 65, then progressively in both ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Flores-Burgess, Antonio; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2017-08-30)
Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura; Gago-Calderón, Belén; Flores-Burgess, Antonio; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo; García-Durán, Laura[et al.] (2019-09-10)
Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-11-18)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; Allén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2019-09-12)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
García-Cantero, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; García-Durán, Laura; Alén, Francisco; Orio, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2021-01-22)
The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
Effects of galanin n-terminal fragment (1-15) in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-21)
Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. The intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) and an ... -
Encapsulación de neuropéptidos mediante la técnica de co-flujo
(2018-03-22)Muchas enfermedades del sistema nervioso central (SNC) pueden ser tratadas dirigiendo fármacos a esta zona del cuerpo. Sin embargo, el camino hacia el encéfalo se ve obstaculizado por una serie de factores, constituyendo ... -
Encapsulación de neuropéptidos mediante la técnica de Electrospraying & Electrospinning coaxial
(2018-03-22)La barrera hematoencefálica (BHE) es una estructura con permeabilidad selectiva que no permite el paso de multitud de sustancias al sistema nervioso central (SNC). Algunos neuropéptidos, como la galanina, y fármacos que ... -
GAL(1-15) induces a depression and anxiogenic effect trough GALR1/GALR2 heteroreceptor: siRNA GALR1/GALR2 knockdown rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
Galanin (1-15) and escitalopram combination in rats reduces alcohol consumption in the ethanol self-administration test and improves escitalopram effects in the forced swimming test.
Cantero-García, Noelia; Flores-Burgess, Antonio; Ladrón de Guevara-Miranda, David; Serrano, Antonia; García-Durán, Laura; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2022-07-12)
Recently, we described that Galanin(1-15)[GAL(1-15)] enhanced Escitalopram(ESC) effectiveness in depression symptoms. Moreover GAL(1-15) induces a substantial reduction in alcohol consumption. To investigate the effect of ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Puigcerver-Martínez, Araceli; Gago-Calderón, Belén; García-Durán, Laura; Cantero-García, Noelia; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2019-06-17)
Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ... -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2017)
The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ...