Listar por autor "Montañez-Vega, María Isabel"
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A perspective of nanotechnology in hypersensitivity reactions including drug allergy
Montañez-Vega, María Isabel
; Ruiz-Sánchez, Antonio Jesús; Perez-Inestrosa, Ezequiel (Lippincott Williams & Wilkins, 2010-08)
Purpose of review We provide an overview of the application of the concepts of nanoscience and nanotechnology as a novel scientific approach to the area of nanomedicine related to the domain of the immune system. Particular ... -
Allergic reactions to β-lactam antibiotics: chemical approaches for improving in vitro diagnosis
(UMA Editorial, 2018-10-16)Drug hypersensitivity reactions are a significant public health problem with important consequences on patient health and healthcare costs. It has been reported that only a low percentage of initial cases suspected of ... -
Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel; González Morena, Juan Manuel; Sanchez Gomez, Francisco J; Salas, María; Montañez-Vega, María Isabel; Altomare, Alessandra; Aldini, Giancarlo; Pajares, Maria Angeles; Pérez-Sala, Dolores[et al.] (Frontiers, 2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
Dendrimer-Modified Solid Supports: Nanostructured Materials with Potential Drug Allergy Diagnostic Applications
Ruiz-Sanchez, Antonio Jesus; Montañez-Vega, María Isabel; Nájera-Albendín, Francisco; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel (Bentham Science, 2012)
Complex functional materials consisting of bioactive molecules immobilized on solid supports present potential applications in biosensoring. Advances in the fabrication of these surface materials are of growing interest ... -
Dendrimeric Antigens. New Approaches Towards Detection of IgE‐Mediated Drug Allergy Reactions
Montañez-Vega, María Isabel; Mayorga, Cristobalina; Torres-Jaén, María Josefa; Ruiz-Sánchez, Antonio Jesús; Malkoch, M; Hult, A; Blanca, Miguel; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (RSC Publishing, 2013-05-31)
Drugs are low molecular weight substances which cannot cause an immune response on their own. However, they can act as haptens and form covalent adducts with proteins. The resulting hapten‐carrier (drug‐protein) conjugate ... -
Dendrímeros antigénicos sobre partículas de sílica para determinar IgE específicas de antibióticos betalactámicos
Matamoros Castellano, Esther; Jiménez, Isabel M.; Gil-Ocaña, Violeta; Mayorga Mayorga, Cristobalina; Doña, Inmaculada; Céspedes Lagos, José Antonio; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Torres-Cazorla, María Isabel[et al.] (2022)
Los inmunoensayos empleados para el diagnóstico in vitro de alergias a antibióticos betalactámicos actualmente presentan una limitada sensibilidad y pobre especificidad, además de no estar disponibles de forma comercial ... -
Design and synthesis of nanostructures to study the specific molecular recognition and effector Cell activation in the immunological responses to amoxicillin
(UMA Editorial, 2022)Amoxicillin (AX) is the penicillin currently regarded as the main culprit in eliciting allergic reactions. According to hapten hypothesis, AX immunogenicity can only be gained by forming covalent conjugates with proteins. ... -
Design of multi-haptenized dendrimeric-antigens for in vitro IgE recognition
Nájera-Albendín, Francisco; Montañez-Vega, María Isabel; Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda; Collado-Martín, Daniel; Pérez-de-Inestrosa-Villatoro, Ezequiel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Blanca Gómez, Miguel[et al.] (2014-06-12)
Reactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, ... -
Fijación de dendrímeros antigénicos en superficies para determinación de IgE
Vida-Pol, Yolanda; Montañez-Vega, María Isabel; Mesa, Pablo; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2016-02-15)
Actualmente, el diseño de nuevos materiales con potenciales aplicaciones biomédicas es de gran importancia , sobre todo para su uso directo en diagnóstico clínico . En particular, los dispositivos que ... -
Identification of an Antigenic Determinant of Clavulanic Acid Responsible for IgE‐mediated Reactions
Barbero, Nekane; Fernández-Santamaría, Rubén; Mayorga, Cristobalina; Martín-Serrano Ortiz, Ángela; Salas, Maria; Bogas, Gador; Nájera-Albendín, Francisco; Pérez-Sala, Dolores; Perez-Inestrosa, Ezequiel; Fernandez, Tahia D; Montañez-Vega, María Isabel; Torres, Maria J[et al.] (John Wiley and Sons Ltd., 2019)
Background: Selective reactions to clavulanic acid (CLV) account for around 30% of immediate reactions after administration of amoxicillin‐CLV. Currently, no immunoas‐ say is available for detecting specific IgE to CLV, ... -
Influence of pore size in protein G'-grafted mesoporous silica nanoparticles as a serum pretreatment system for in vitro allergy diagnosis
Paris, Juan Luis; Monío, Cristina; Pérez-Moreno, Ana M.; Jurado-Escobar, Raquel; Bogas Herrera, Gádor; Fernández-Duarte, Tahía Diana; Montañez-Vega, María Isabel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (Wiley, 2023)
Particles with the capacity to bind to immunoglobulin G (IgG) can be used for the purification of IgG or to process clinical samples for diagnostic purposes. For in vitro allergy diagnosis, the high IgG levels in serum can ... -
New approaches for Basophil Activation Tests employing Dendrimeric Antigen-Silica Nanoparticle composites.
Calvo-Serrano, Silvia; Matamoros, Esther; Céspedes, José Antonio; Fernández-Santamaría, Rubén; Gil-Ocaña, Violeta; Pérez-Inestrosa, Ezequiel; Frecha, Cecilia; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (MDPI, 2024-08-03)
In vitro detection of specific IgE bound to high-affinity receptor on basophils’ surface is 25 a widely used strategy for the evaluation of IgE-mediated immediate hypersensitivity reactions to 26 drugs. Due to the drug ... -
Recognition of multiepitope dendrimeric antigens by human immunoglobulin E.
Montañez-Vega, María Isabel; Nájera-Albendín, Francisco; Mayorga, Cristobalina; Ruiz-Sánchez, Antonio Jesús; Vida-Pol, Yolanda; Collado-Martín, Daniel; Blanca, Miguel; Torres-Jaén, María Josefa; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (Elsevier, 2015-02-07)
In vitro drug allergy tests have limited sensitivity, partly due to a poor understanding of the immunological recognition of in vitro drug–protein conjugates. We have designed and synthesized multivalent mono- and bi-epitope ... -
Role of minor determinants of amoxicillin in the diagnosis of immediate allergic reactions to amoxicillin.
Background: Skin testing of subjects with immediate hypersensitivity to amoxicillin is performed using major and minor determinants of benzylpenicillin plus amoxicillin. However, sensitivity is not optimal, and other ... -
Silica Particle based nanocomposites for Specific IgE Determination to Betalactams
Matamoros Castellano, Esther; Gil-Ocaña, Violeta; Jiménez, Isabel M.; Mayorga Mayorga, Cristobalina; Doña, Inmaculada; Céspedes Lagos, José Antonio; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel; Torres-Jaén, María Josefa[et al.] (2023)
Current immunoassays for diagnosing betalactam (BL) allergy have limited sensitivity and poor specificity. These include ImmunoCAP, the commercial immunoassay, and the radioallergosorbent test (RAST), a handmade test ... -
Síntesis y estudio de determinantes antigénicos de cefalosporinas y antígenos dendriméricos de penicilinas, para la detección de IgE dirigidas a â-lactamas
Montañez-Vega, María Isabel (Universidad de Málaga,Servicio de Publicaciones, 2006)
El objetivo de este estudio está enfocado al desarrollo y la mejora de los métodos de diagnósticos in vitro e in vivo, para la detección de anticuerpos IgE dirigidos a antibióticos â-lactámicos. -
Synthetic antigenic determinants of clavulanic acid induce dendritic cell maturation and specific T cell proliferation in patients with immediate hypersensitivity reactions
Fernández-Santamaría, Rubén; Bogas Herrera, Gádor; Montañez-Vega, María Isabel; Ariza Veguillas, Adriana; Salas, María; Céspedes Lagos, José Antonio; Labella, Marina; Paris, Juan Luis; Pérez-Sánchez, Natalia Isabel; Pérez-de-Inestrosa-Villatoro, Ezequiel; Vida-Pol, Yolanda; Fernández-Duarte, Tahía Diana; Mayorga Mayorga, Cristobalina[et al.] (Wiley, 2022-05-24)
Background Immediate drug hypersensitivity reactions (IDHRs) to clavulanic acid (CLV) have increased in the last decades due to a higher consumption alongside amoxicillin (AX). Due to its chemical instability, diagnostic ... -
The Role of Benzylpenicilloyl Epimers in Specific IgE Recognition
Mayorga, Cristobalina; Montañez-Vega, María Isabel; Nájera-Albendín, Francisco; Bogas Herrera, Gádor; Rodriguez Gil, David; Palacios, Ricardo; Torres-Jaén, María Josefa; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel[et al.] (Frontiers, 2021)
The high prevalence of allergy to β-lactam antibiotics is a worldwide issue. Accuracy of diagnostic methods is important to prove tolerance or allergy, with skin test considered the best validated in vivo method for ...