Listar por autor "Real-Navarrete, Luis Miguel"
Mostrando ítems 1-10 de 10
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A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer’s Disease
Esteban-Martos, Alvaro; Brokate-Llanos, Ana María; Real-Navarrete, Luis Miguel
; Melgar-Locatelli, Sonia; De Rojas, Itziar; Castro-Zavala, Adriana; Bravo-Romero, María José; Mañas-Padilla, María del Carmen; García-González, Pablo; Ruiz-Galdón, Maximiliano; Pacheco-Sánchez, Beatriz; Polvillo, Rocío; Rodriguez-de-Fonseca, Fernando; González, Irene; Castilla-Ortega, María Estela; Muñoz-Gómez, Manuel; Rivera, Patricia; Reyes-Engel, Armando; Ruiz, Agustín; Royo-Sánchez-Palencia, José Luis[et al.] (MDPI, 2023)
Genome-wide association studies (GWAS) constitute a powerful tool to identify the different biochemical pathways associated with disease. This knowledge can be used to prioritize drugs targeting these routes, paving the ... -
A metagenome-wide association study of HIV disease progression in HIV controllers.
Real-Navarrete, Luis Miguel; Saéz, María E; Corma-Gómez, Anaïs; González-Pérez, Antonio; Thorball, Christian; Ruiz, Rocío; Jiménez-León, María Reyes; González-Serna, Alejandro; Gasca-Capote, Carmen; Bravo-Romero, María José; Royo-Sánchez-Palencia, José Luis; Pérez-Gómez, Alberto; Camacho-Sojo, María Inés; Gallego, Isabel; Joana, Vitalle; Bachiller, Sara; Gutierrez-Valencia, Alicia; Vidal, Francisco; Fellay, Jacques; Lichterfeld, Mathias; Ruiz-Mateos, Ezequiel[et al.] (Elsevier, 2023)
Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 ... -
An intragenic duplication within SIRPβ1 shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial response.
García-Alberca, JM; de Rojas, I; Sánchez-Mejías, Elisabeth; Garrido-Martín, D; Gonzalez-Palma, L; Jimenez, S; Pino-Angeles, A; Cruz-Gamero, JM; Mendoza, S; Alarcón-Martín, E; Muñoz-Castro, Clara; Real-Navarrete, Luis Miguel; Tena, Juan J.; Polvillo, R; Govantes, F; Lopez, A; Royo-Aguado, JL; Navarro, V; Gonzalez, I; Ruiz, M; Reyes-Engel, Armando; Gris, E; Bravo, MJ; Lopez-Gutierrez, L; Mejías-Ortega, Marina; De la Guía, María Paz; López de la Rica, M; Ocejo, Olga; Torrecilla, J; Zafra, C; Nieto, MD; Urbano, C; Jiménez-Sánchez, R; Pareja, N; Luque, M; García-Peralta, María; Carrillejo, Rosario; Furniet, MDC; Rueda, L; Sánchez-Fernández, A; Mancilla, T; Peña, I; García-Casares, N; Moreno-Grau, S; Hernández, I; Montrreal, L; Quintela, I; González-Pérez, A; Calero, M; Franco-Macías, Emilio; Macías, J; Menéndez-González, M; Frank-García, A; Huerto Vilas, R; Diez-Fairen, M; Lage, C; García-Madrona, S; García-González, P; Valero, S; Sotolongo-Grau, O; Pérez-Cordón, A; Rábano, A; Arias Pastor, A; Pastor, AB; Espinosa, A; Corma-Gómez, A; Martín Montes, A; Sanabria, A; Martínez Rodríguez, C; Buiza-Rueda, D; Rodriguez-Rodriguez, E; Ortega, G; Alvarez, I; Rosas Allende, I; Pineda, JA; Rosende-Roca, M; Bernal Sánchez-Arjona, M; Fernández-Fuertes, M; Alegret, M; Roberto, N; Del Ser, T; Garcia-Ribas, G; Sánchez-Juan, P; Pastor, P; Piñol-Ripoll, G; Bullido, MJ; Álvarez, V; Mir, P; Medina, M; Marquié, M; Sáez, ME; Carracedo, A; Laplana, M; Tomas-Gallardo, L; Orellana, A; Tárraga, LL; Boada, M; Fibla Palazon, J; Vitorica Ferrández, Javier; Ruiz, A; Guigo, R; Gutiérrez-Pérez, Antonia; Royo-Sánchez-Palencia, José Luis[et al.] (SAGE, 2024)
Microglia play an important role in the maintenance of brain homeostasis, and microglial dysfunction plays a causative role in Alzheimer disease pathogenesis. Here we focus on the signal regulatory protein SIRPβ1, a surface ... -
Correction to: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano, Antonio; Ruiz, Rocío; Sánchez-Varo, Raquel María; García-Revilla, Juan; Yang, Yiyi; Jiménez-Ferrer, Itzia; Paulus, Agnes; Wennström, Malin; Vilalta, Anna; Allendorf, David; Dávila-Cansino, José Carlos; Stegmayr, John; Jiménez, Sebastián; Roca-Ceballos, Maria A.; Navarro-Garrido, Victoria; Swanberg, Maria; Hsieh, Christine L; Real-Navarrete, Luis Miguel; Englund, Elisabeth; Linse, Sara; Leffler, Hakon; Nilsson, Ulf J.; Brown, Guy C; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Venero, José Luis; Deierborg, Thomas[et al.] (Springer, 2023-02-15)
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ... -
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano, Antonio; Ruiz, Rocio; Sánchez-Varo, Raquel María; García‑Revilla, Juan; Yang, Yiyi; Jiménez-Ferrer, Itzia; Paulus, Agnes; Wennström, Malin; Vilalta, Ana; Allendorf, David; Dávila-Cansino, José Carlos; Stegmayr, John; Jiménez, Sebastián; Roca-Ceballos, Maria A.; Navarro-Garrido, Victoria; Swanberg, Maria; Hsieh, Christine L.; Real-Navarrete, Luis Miguel; Englund, Elisabeth; Linse, Sara; Leffler, Hakon; Nilsson, Ulf J.; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Venero, José Luis; Deierborg, Thomas[et al.] (Springer, 2019-04-20)
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ... -
Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic
Fernández-Fuertes, Marta; Corma-Gómez, Anaïs; Torres, Eva; Rodriguez-Pineda, Elena; Fuentes-López, Ana; Rincon, Pilar; Fernández, Nieves; García, Federico; Bernal, Samuel; Real-Navarrete, Luis Miguel; Macías, Juan; Pineda, Juan A.[et al.] (Wiley, 2021-08-17)
Whether people living with HIV (PLWH) are at greater risk of acquiring SARS-CoV-2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. ... -
Incidence of recently acquired hepatitis C virus infection among HIV-infected patients in southern Spain.
González-Serna, A.; Macías, Juan; Palacios-Muñoz, María Rosario; Gómez Ayerbe, Cristina; Téllez-Rico, Francisco Javier; Rivero-Juárez, Antonio; Fernández, M.; Santos-González, Jesús Leandro; Real-Navarrete, Luis Miguel; González-Doménech, Carmen María; Gómez-Mateos, J.; Pineda, Juan Antonio; HEPAVIR study group[et al.] (2020-12-26)
Objectives: Spain is close to HCV microelimination, so rates of recently acquired HCV infection (RAHC) should decrease. Nowadays, men who have sex with men (MSM) carry the highest risk of HCV acquisition. Our aim was to ... -
Mendelian Randomisation Confirms the Role of Y-Chromosome Loss in Alzheimer’s Disease Aetiopathogenesis in Men
García-González, Pablo; Rojas, Itziar de; Moreno-Grau, Sonia; Montrreal, Laura; Puerta, Raquel; Alarcón-Martín, Emilio; Quintela, Inés; Orellana, Adela; Andrade, Victor; Martino Adami, Pamela V.; Heilmann-Heimbach, Stefanie; Gómez-Garre, Pilar; Periñán, María Teresa; Alvarez, Ignacio; Díez-Fairen, Mónica; Nuñez Llaves, Raul; Olivé Roig, Claudia; García-Ribas, Guillermo; Menéndez-González, Manuel; Martínez, Carmen; Aguilar, Miquel; Buongiorno, Mariateresa; Franco-Macías, Emilio; Saez, Maria Eugenia; Cano, Amanda; Bullido Gómez-Heras, Maria Jesús; Real-Navarrete, Luis Miguel; Rodríguez-Rodríguez, Eloy; Royo-Sánchez-Palencia, José Luis; Álvarez, Victoria; Pastor, Pau; Piñol-Ripoll, Gerard; Mir, Pablo; Calero Lara, Miguel; Medina Padilla, Miguel; Sánchez-Juan, Pascual; Carracedo Álvarez, Ángel María; Valero, Sergi; Hernández, Isabel; Tàrraga, Lluis; Ramirez, Alfredo; Boada, Mercé; Ruiz Laza, Agustín[et al.] (IOAP-MDPI, 2023-01-04)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY ... -
The absence of seroconversion after exposition to hepatitis C virus is not related to KIR-HLA genotype combinations (GEHEP-012 study).
Martín-Sierra, Carmen; Bravo-Romero, María José; Saez, Maria Eugenia; De Rojas, Itziar; Santos, Marta; Martín-Carmona, Jesica; Corma-Gómez, Anaïs; González-Serna, Alejandro; Royo-Sánchez-Palencia, José Luis; Pineda, Juan A.; Rivero, Antonio; Rivero-Juárez, Antonio; Macías, Juan; Real-Navarrete, Luis Miguel[et al.] (Elsevier, 2024)
Background & aims It has been reported that specific killer-cell immunoglobulin-like receptors (KIRs) and HLA genotype combinations, such as KIR2DS4/HLA-C1 with presence of KIRDL2 or KIRDL3, homozygous KIRDL3/HLA-C1 and ... -
Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
Laplana, Marina; Bravo-Romero, María José; Fernández-Fuertes, Marta; Ruiz-García, Celia; Alarcón-Martín, Emilio; Colmenero Castillo, Juan de Dios; Caruz-Arcos, Antonio; Fibla, Joan; Real-Navarrete, Luis Miguel; Royo-Sánchez-Palencia, José Luis[et al.] (Oxford Academy, 2020)
Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its ...