Listar por autor "Rodríguez-Pérez, Luis Manuel"
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A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis.
Rodríguez-Pérez, Luis Manuel
; López-de-San-Sebastián, Javier; De-Diego-Barbado, Isabel; Smith-Fernández, José Aníbal; Roales-Buján, Ruth; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (Frontiers, 2024-02-21)
INTRODUCTION Dysgenesis of the corpus callosum is present in neurodevelopmental disorders and coexists with hydrocephalus in several human congenital syndromes. The mechanisms that underlie the etiology of congenital ... -
A sequential cell therapy to recover the ependymal cells in posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; González-García, Marcos; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (2022-09)
Background Germinal matrix haemorrhages and intraventricular haemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a relevant cause of morbidity and mortality in the premature neonatal population. The ... -
Desarrollo del epéndimo y subepéndimo en modelos animales en condiciones normales y en la hidrocefalia congénita
Rodríguez-Pérez, Luis Manuel (Servicio de Publicaciones y Divulgacion Cientifica, 2016)
La presente Tesis Doctoral se ha diseñado para responder a las siguientes hipótesis: 1.- El programa de diferenciación de la zona ventricular que se afecta en el ratón hyh pone de manifiesto que la población celular que ... -
Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages
Rodríguez-Pérez, Luis Manuel; Ojeda-Pérez, Betsaida; López-de-San-Sebastián, Javier; García-Bonilla, María; González-García, Marcos; Fernandez-Muñoz, Beatriz; Sánchez Pernaute, Rosario; García-Martín, María L.; Domínguez-Pinos, Dolores; Cárdenas García, Casimiro; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia[et al.] (AHA/ASA Journals, 2024-04)
BACKGROUND: In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities ... -
Gastrointestinal cancer: Relationship between histology and microbiota
García Sanz, A; Escamilla-Sánchez, Alejandro; Mercado-Sáenz, Silvia; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Sánchez-Varo, Raquel María; Peláez-González, Alberto Carlos; López-Villodres, Juan Antonio; Bermúdez-Flores, Diego Teófilo[et al.] (2022-09-09)
Objectives: Review of the published literature concerning the relationship between microbiome and gastrointestinal cancer. Methods: Present work is focused on systematic research in the most prominent biomedical databases ... -
Gastrointestinal Stromal Tumor (GIST) and its relationship with germline mutations
Arranz-Salas, Isabel María; Jiménez-Campillo, Marta; Hierro-Martín, María Isabel; Ortega-Jiménez, María Victoria; Mercado-Sáenz, Silvia; Rodríguez-Pérez, Luis Manuel; Sánchez-Varo, Raquel María; Escamilla-Sánchez, Alejandro; Peláez-González, Alberto Carlos; Bermúdez-Flores, Diego Teófilo[et al.] (2022)
We present the case of a 38-year-old man with a history of abdominal paraganglioma 10 years ago, who consulted for hematemesis and asthenia of 5 days' evolution. An upper gastrointestinal endoscopy was performed where a ... -
Generation of periventricular reactive astrocytes overexpressing aquaporin 4 Is stimulated by mesenchymal stem cell therapy
García-Bonilla, María; Ojeda-Pérez, Betsaida; Shumilov, Kirill; Rodríguez-Pérez, Luis Manuel; Domínguez-Pinos, Dolores; Vitorica Ferrández, Javier; Jiménez, Sebastián; Ramírez-Lorca, Reposo; Echevarría, Miriam; Cárdenas García, Casimiro; Iglesias, Teresa; Gutiérrez-Pérez, Antonia; McAllister, James P. (II); Limbrick, David D. (Jr.); Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (MDPI, 2023-03-15)
Aquaporin-4 (AQP4) plays a crucial role in brain water circulation and is considered a therapeutic target in hydrocephalus. Congenital hydrocephalus is associated with a reaction of astrocytes in the periventricular white ... -
Human Mesenchymal Stem Cells and its Exosomes in Posthemorrhagic Hydrocephalus: A Focus on Edema and Ependymal Repair
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; Anguita-Guardia, Alba; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (SRHSB 2024 Annual Conference, 2023-09-04)
Background Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) often lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH is known to ... -
IPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalus
Introduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) ... -
iPSC differentiation into ependymal progenitors to treat ventricular damage during hydrocephalus
Rodríguez-Pérez, Luis Manuel; Hidalgo-Díaz, Juan Antonio; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (2019-07-03)
Introduction: During both obstructive congenital hydrocephalus and post-hemorrhagic hydrocephalus additional pathological events are intimately associated with their ethiology: a) a detrimental inflammatory response; b) ... -
Microbiome alterations and Alzheimer's Disease: modeling strategies with transgenic mice.
López-Villodres, Juan Antonio; Escamilla-Sánchez, Alejandro; Mercado-Sáenz, Silvia; Alba-Tercedor, Carmen; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Sánchez-Varo, Raquel María; Bermúdez-Flores, Diego Teófilo[et al.] (MDPI, 2023-06-27)
In the last decade, the role of the microbiota-gut-brain axis has been gaining momentum in the context of many neurodegenerative and metabolic disorders, including Alzheimer's disease (AD) and diabetes, respectively. ... -
Multiciliated ependyma recovery through a sequential cell therapy in posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; González-García, Marcos; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús (2023)
Posthemorrhagic hydrocephalus (PHH) is a significant cause for premature children’s morbidity, mortality, and peri/postnatal neurodevelopmental impairment. PHH is mainly triggered by germinal matrix hemorrhages (GMH) and ... -
NG2 cells in an animal model of congenital hydrocephalus
Jiménez-Lara, Antonio Jesús; Ojeda-Pérez, Betsaida; García-Bonilla, María; Ruz-Maldonado, Inmaculada; Mateos-Grondona, Jesús; Rodríguez-Pérez, Luis Manuel; Páez-González, Patricia[et al.] (2017-06-28)
NG2 cells are considered oligodendrocyte precursor cells (OPC). In pathological conditions, NG2 cells contribute to generate oligodendrocytes and reactive astrocytes. This study has been designed to uncover the role of NG2 ... -
Oligodendrocyte metabolism throughout its differentiation: immunocytochemistry study and its impact in remyelination
Gismero Rodríguez, Javier; López-Villodres, Juan Antonio; Escamilla-Sánchez, Alejandro; García Díaz, Beatriz; Rodríguez-Pérez, Luis Manuel; Mercado-Sáenz, Silvia; Ortega-Jiménez, María Victoria; Arranz-Salas, Isabel María; Peláez-González, Alberto Carlos; Bermúdez-Flores, Diego Teófilo[et al.] (2022-09-07)
Introduction: Oligodendrocytes (OL) role in demyelinating pathologies such as multiple sclerosis and other neurodegenerative diseases is only recently being subject of extensive research. While the genetic and molecular ... -
Protein homeostasis as a therapeutical target for Alzheimer’s disease: analysis in the hippocampus of transgenic mouse models
Sánchez-Varo, Raquel María; Criado-Álamo, Elena; Fernández-Valenzuela, Juan José; Mercado-Sáenz, Silvia; López-Villodres, Juan Antonio; Escamilla-Sánchez, Alejandro; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Ortega-Jiménez, Concepción; Alba-Tercedor, Carmen; Gutiérrez-Pérez, Antonia[et al.] (2022-09)
Alzheimer's disease (AD) constitutes the most prevalent form of dementia. There is no cure so there is an urgent need of novel therapeutic targets and treatments. The main histopathological hallmarks of AD brains are ... -
Testing exosomes as a treatment for posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; Anguita-Guardia, Alba; Jiménez-Lara, Antonio Jesús; Páez-González, Patricia (2023)
Germinal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which forms ... -
Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development.
Páez-González, Patricia; López-de-San-Sebastián, Javier; Cerón-Fúnez, Raquel; Jiménez-Lara, Antonio Jesús; Rodríguez-Pérez, Luis Manuel (Frontiers, 2023)
The epithelium covering the surfaces of the cerebral ventricular system is known as the ependyma, and is essential for maintaining the physical and functional integrity of the central nervous system. Additionally, the ...