Listar por autor "Romero-Zerbo, Silvana Yanina"
Mostrando ítems 1-20 de 32
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Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage
González-Mariscal, Isabel; Pozo-Morales, Macarena; Romero-Zerbo, Silvana Yanina
; Espinosa-Jiménez, Vanesa; Escamilla-Sánchez, Alejandro; Sánchez-Salido, Lourdes; Cobo-Vuilleumier, Nadia; Gauthier, Benoit R.; Bermúdez Silva, Francisco Javier[et al.] (Elsevier, 2021-12-03)
The atypical cannabinoid Abn-CBD improves the inflammatory status in preclinical models of several pathologies, including autoimmune diseases. However, its potential for modulating inflammation in autoimmune type 1 diabetes ... -
Alpha-tocopherol protects against oxidative stress in the fragile X knockout mouse: an experimental therapeutic approach for the Fmr1 deficiency.
De Diego‑Otero, Yolanda; Romero-Zerbo, Silvana Yanina; El-Bekay, Rajaa; Decara, Juan; Sánchez-Salido, Lourdes; Rodriguez-de-Fonseca, Fernando; Del Arco-Herrera, Ignacio[et al.] (Springer Nature, 2009)
Fragile X syndrome is the most common genetic cause of mental disability. The mechanisms underlying the pathogenesis remain unclear and specific treatments are still under development. Previous studies have proposed an ... -
Antioxidant and neuroprotective actions of IGF-II against glucocorticoid-induced toxicity in dopaminergic neurons.
Claros-Gil, Silvia; Valverde Moreno, Nadia; Zamorano-González, Pablo; Romero-Zerbo, Silvana Yanina; Lara Fernández, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
The neurodegenerative Parkinson’s disease (PD) affects 1–3% of the population aged over 65. A wide range of pathways and mechanisms are involved in its pathogenesis, such as oxidative stress, mitochondrial dysfunction, ... -
Cannabinoids, eating behaviour, and energy homeostasis
Romero-Zerbo, Silvana Yanina; Bermúdez Silva, Francisco Javier (John Wiley & Sons, 2014)
Soon after the discovery of cannabis by western societies, its psychotropic effects overshadowed its medical benefits. How-ever, investigation into the molecular action of the main constituents of cannabis has led to the ... -
Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas-Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero-Zerbo, Silvana Yanina; García-Fernández, María Inmaculada; Santín-Núñez, Luis Javier[et al.] (2022-07)
Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Cocaine detrimentally affects mitochondrial functionality and cell viability in dopaminergic neurons.
Zamorano-González, Pablo; Bandini, Luca; Valverde, Nadia; Claros-Gil, Silvia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Santín-Núñez, Luis Javier; Martín-Montañez, Elisa; Gago-Calderón, Belén; García-Fernández, María Inmaculada[et al.] (2024)
An elevated consumption of cocaine (benzoylmethylecgonine), which causes anesthetic and stimulant effects on the central nervous system, may be associated with several neurodegenerative conditions affecting dopaminergic ... -
Differences in the neovascular potential of thymus versus subcutaneous adipose-derived stem cells from patients with myocardial ischaemia.
Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Lhamyani, Said; Salas-Millán, Manuel Julián; Gentile, Adriana Mariel; Romero-Zerbo, Silvana Yanina; Zayed, Hatem; Valderrama-Marcos, José Francisco; Tinahones-Madueño, Francisco José; El-Bekay, Rajaa[et al.] (Wiley, 2017)
Adipose tissue‐derived multipotent mesenchymal cells (ASCs) participate in the information ofblood vessels under hypoxic conditions. It is probable that the susceptibility of ASCs to theinfluence of age and ageing‐associated ... -
Dissecting the Brain/Islet Axis in Metabesity
Mellado-Gil, Jose M; Cobo-Vuilleumier, Nadia; Martín-Montalvo, Alejandro; Romero-Zerbo, Silvana Yanina; Diaz Contreras, Irene; Hmadcha, Abdelkrim; Soria, Bernat; Martin Bermudo, Francisco; Reyes, Jose C; Bérmudez-Silva, Francisco Javier; Lorenzo, Petra I; Gauthier, Benoit R[et al.] (MDPI, 2019)
The high prevalence of type 2 diabetes mellitus (T2DM), together with the fact that current treatments are only palliative and do not avoid major secondary complications, reveals the need for novel approaches to treat the ... -
Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats.
Suárez-Pérez, Juan; Llorente, Ricardo; Romero-Zerbo, Silvana Yanina; Mateos, Beatriz; Bermúdez Silva, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Paz Viveros, Maria; Suárez-Pérez, Juan[et al.] (Wiley, 2009)
Early maternal deprivation (MD) in rats (24 h, postnatal day 9–10) is a model for neurodevelopmental stress. There are some data proving that MD affects the endocannabinoid system (ECS) in a gender-dependent manner, and ... -
Efecto del factor de crecimiento insulínico tipo II sobre el daño oxidativo-mitocondrial y neuronal inducido por MPP+ y corticosterona en neuronas dopaminérgicas en cultivo
(UMA Editorial, 2023)La Enfermedad de Parkinson (EP), es el trastorno de movimiento más frecuente, siendo la segunda causa de enfermedad neurodegenerativa en todo el mundo. Se caracteriza por la aparición progresiva de síntomas motores y ... -
Efficacy and safety of basal insulin degludec 100 IU/mL versus glargine 300 IU/mL for type 1 diabetes: the single-center INEOX randomized controlled trial.
Ruiz de Adana Navas, María Soledad; Domínguez, Marta Elena; Morillas, Virginia; Colomo, Natalia; Vallejo Mora, María del Rosario; Guerrero, Mercedes; García-Escobar, Eva; Carreira-Soler, Mónica; Romero-Zerbo, Silvana Yanina; Linares, Francisca; González-Mariscal, Isabel; Bermúdez Silva, Francisco Javier; Olveira-Fuster, Gabriel María; Rojo-Martínez, Gemma[et al.] (Elsevier, 2023)
Aims To compare efficacy and safety of degludec 100 IU/mL (Deg-100) and glargine 300 IU/mL (Gla-300) in adults with type 1 diabetes. Methods Open-label, single-center, randomized, parallel-group, 24-week trial in adults ... -
Enhanced markers of oxidative stress, altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice, a pathological model for Fragile X syndrome.
El-Bekay, Rajaa; Romero-Zerbo, Silvana Yanina; Decara, Juan; Sánchez-Salido, Lourdes; Del Arco-Herrera, Ignacio; Rodriguez-de-Fonseca, Fernando; De Diego‑Otero, Yolanda[et al.] (Wiley, 2007)
Fragile X syndrome is the most common form of inherited mental retardation in humans. It originates from the loss of expression ofthe Fragile X mental retardation 1 (FMR1) gene, which results in the absence of the Fragile ... -
IGF-II treatment prevents the oxidative damage derived by MPP+/MPTP administration in a cellular and animal model of Parkinson’s disease.
Zamorano-González, Pablo; Valverde, Nadia; Claros-Gil, Silvia; López-González, Manuel Víctor; Romero-Zerbo, Silvana Yanina; Lara, Estrella; Boraldi, Federica; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (2023)
El factor de crecimiento de la insulina-II (IGF-II) ha mostrado efectos antioxidantes y neuroprotectores en algunos trastornos neurodegenerativos, como es la Enfermedad de Parkinson (EP). Analizamos el efecto de IGF-II ... -
Insulin-like growth factor II neuroprotective effects against mitochondrial-oxidative and neuronal damage induced by CORT and MPP+ in dopaminergic neurons
Claros-Gil, Silvia; Cabrera García, Pablo; Valverde, Nadia; Romero-Zerbo, Silvana Yanina; Lara, Estrella; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (2022-07-12)
Aims: Parkinson’s disease (PD) affects 1–3% of the population aged over 65. Stress seems to contribute to PD neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors are oxidative ... -
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
Claros-Gil, Silvia; Cabrera, Pablo; Valverde, María; Romero-Zerbo, Silvana Yanina; López-González, Manuel Víctor; Shumilov, Kirill; Rivera-Ramírez, Alicia; Pavía-Molina, José; Martín-Montañez, Elisa; García-Fernández, María Inmaculada[et al.] (MDPI, 2021-12-24)
Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial ... -
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Cobo-Vuilleumier, Nadia; Lorenzo, Petra I; García Rodríguez, Noelia; Herrera Gómez, Irene de Gracia; Fuente-Martin, Esther; López-Noriega, Livia; Mellado-Gil, José Manuel; Romero-Zerbo, Silvana Yanina; Baquié, Mathurin; Lachaud, Christian Claude; Stifter, Katja; Perdomo, German; Bugliani, Marco; De Tata, Vincenzo; Bosco, Domenico; Parnaud, Geraldine; Pozo, David; Hmadcha, Abdelkrim; Florido, Javier P; Toscano, Miguel G; de Haan, Peter; Schoonjans, Kristina; Sánchez Palazón, Luis; Marchetti, Piero; Schirmbeck, Reinhold; Martín-Montalvo, Alejandro; Meda, Paolo; Bernat, Soria; Bermúdez Silva, Francisco Javier; St-Onge, Luc; Gauthier, Benoit R[et al.] (Nature Research, 2018)
Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited ... -
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
Gentile, Adriana Mariel; Lhamyani, Said; Coín-Aragüez, Leticia I.; Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana Yanina; García Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez Silva, Francisco Javier; Murri, Mora; Tinahones-Madueño, Francisco José; El-Bekay, Rajaa[et al.] (Wiley, 2019)
Objective: This study aimed to analyze the potential association of different microRNA (miRNA) moleculeswith both type 2 diabetes (T2D) and obesity and determine their target genes.Methods: Quantitative PCR was used to ... -
Neuroprotective effects of insulin-like growth factor II in a mouse model of Parkinson's disease
Ladrón de Guevara-Miranda, David; Martín-Montañez, Elisa; Valverde, Nadia; Lara, Estrella; Romero-Zerbo, Silvana Yanina; Millón-Peñuela, Carmelo; Boraldi, Federica; Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Garrido-Gil, Pablo; Labandeira-García, José Luis; Santín-Núñez, Luis Javier; Pavía-Molina, José; García-Fernández, María Inmaculada[et al.] (2022-07-20)
Progressive degeneration of the nigrostriatal dopaminergic pathway is a core, currently irreversible pathological hallmark of Parkinson’s disease (PD) that leads to a variety of motor and non-motor symptoms. Here, we aimed ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)
Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Overexpression of Cannabinoid CB2 Receptor in the Brain Induces Hyperglycaemia and a Lean Phenotype in Adult Mice
Romero-Zerbo, Silvana Yanina; Garcia-Gutierrez, M S; Suárez-Pérez, Juan; Rivera, Patricia; Ruz-Maldonado, Inmaculada; Vida, M.; Rodriguez-de-Fonseca, Fernando; Manzanares, Jorge; Bermúdez Silva, Francisco Javier[et al.] (Blackwell Publishing Ltd, 2009)
t is well known that the endocannabinoid system, through cannabinoid CB1 receptor activation,has an important role in the main aspects of energy balance (i.e. food intake, energy expenditureand glucose and fat metabolism), ...