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Listar por autor "Suárez-Pérez, Juan"
Mostrando ítems 1-20 de 21
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Antipsychotic Medication Influences the Discriminative Value of Acylethanolamides as Biomarkers of Substance Use Disorder.
Herrera-Imbroda, Jesús; Flores-López, María; Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Ropero, Jessica; García-Marchena, Nuria; Bordallo Aragón, Antonio; Suárez-Pérez, Juan; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Rodriguez-de-Fonseca, Fernando[et al.] (MDPI, 2023-05-27)Plasma acylethanolamides (NAEs), including the endocannabinoid anandamide (AEA), have been proposed as circulating biomarkers of substance use disorders. However, the concentration of these lipid transmitters might be ... -
Behavioral traits predicting cocaine-conditioned place reference in mice: role of anxiety adn the basolateral amygdala
Ladrón de Guevara-Miranda, David; Pavón-Morón, Francisco Javier; Serrano, Antonia; Rivera, Patricia; Estivill-Torrús, Guillermo; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2016-07-13)Aims. The individual susceptibility to cocaine addiction, a factor of interest in the understanding and prevention of this disorder, may be predicted by certain behavioral traits. However, these are not usually taken into ... -
Chronic ethanol induces morpohological changes on hippocampal microglia, which are reverted by pharmacological blockade of faah with urb597
Fernández-Arjona, María del Mar; Rivera, Patricia; Silva-Peña, Daniel; Blanco, Eduardo; Vargas, Antonio; López-Ávalos, María Dolores; Mateos-Grondona, Jesús; Serrano, Antonia; Pavón-Morón, Francisco Javier; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2018-11-29)Here, we evaluated the pharmacological effects of fatty-acid amide-hydrolase (FAAH) inhibitor URB597 (0.3 mg/kg), oleoylethanolamide (OEA, 10 mg/kg), arachidonoylethanolamide (AEA, 10 mg/kg), the CB1 receptor agonist ACEA ... -
Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis
Vega-Núñez, Amanda; Gómez-Sánchez-Lafuente, Carlos; Mayoral Cleries, Fermín; Bordallo Aragón, Antonio; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (IOAP-MPDI, 2022-06-09)Bipolar disorder (BD) is a multifactorial chronic psychiatric disease highly defined by genetic, clinical, environmental and social risk factors. The present systematic review and meta-analysis aimed to examine the ... -
Dental color measurement to estimate age in adults: a systematic review and meta‑analysis
Martín-Martín, Jaime; Santos-Amaya, Ignacio Miguel; Gaitán‑Arroyo, María J.; Suárez-Pérez, Juan; Rubio-Lamia, Leticia Olga; Martin-de-las-Heras, Stella[et al.] (Springer Nature, 2024-03-08)Age estimation is a major challenge in anthropology and forensic odontology laboratories, as well as in judicial settings, as one of the tools used in human identification. The aim of this study was to evaluate the usefulness ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ... -
Efecto del tratamiento antidepresivo fluoxetina sobre la microglía en regiones del sistema corticolímbico en un modelo preclínico de autoadministración de alcohol, fase de abstinencia y recaída
Aranda-López, Jesús (UMA Editorial, 2023-03-02)Estado actual y justificación de la tesis: El alto consumo de alcohol (abuso y dependencia), principalmente en la población joven, y su alta comorbilidad con trastornos ansiosos-depresivos y su ulterior asociación con ... -
Estudio de la eficacia de la administración dietética del D-Chiro-inositol en la señalización de insulina, neuroinflamación y alteraciones metabólicas en un modelo animal de la enfermedad de Alzheimer
López Gambero, Antonio Jesús (UMA Editorial, 2023-03-02)La enfermedad de Alzheimer (EA) es un trastorno con un origen mayoritariamente esporádico caracterizado por el deterioro de la memoria, razonamiento y lenguaje, que conduce a la muerte pocos años después del diagnóstico. ... -
LH-21, a CB1 antagonist, reduces hepatotoxic damage produced by paracetamol overdose in a mice model.
Rodríguez-Pozo, Miguel; Gavito, Ana Luisa; Jagerovic, Nadine; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan; Rivera, Patricia; Decara, Juan[et al.] (2023)Drug-induced liver injury (DILI) is one of the main causes of hepatic acute failure. Paracetamol can cause it when is ingested in excessive doses, leading to the depletion of the antioxidant mechanisms of the hepatocytes ... -
Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Pavón-Morón, Francisco Javier; Serrano, Antonia; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2019)Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal- directed behaviors become corrupted, which may lead ... -
Partners in postmortem interval estimation: X-ray diffraction and Fourier transform spectroscopy
Rubio-Lamia, Leticia Olga; Suárez-Pérez, Juan; Martín-de-las-Heras, Stella; Zapico, Sara C. (MDPI, 2023-04-05)The postmortem interval (PMI) is difficult to estimate in later stages of decomposition. There is therefore a need to develop reliable methodologies to estimate late PMI. This study aims to assess whether there is a ... -
Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease.
Flores-López, María; García-Marchena, Nuria; Pavón-Morón, Francisco Javier; Lara, Estrella; Porras Perales, Óscar; Araos, Pedro; Requena-Ocaña, Nerea; Torres-Galván, Sandra; Mañas-Padilla, María del Carmen; Rubio, Gabriel; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; García-Fernández, María Inmaculada; Serrano, Antonia[et al.] (2021-09-13)Lysophosphatidic acid (LPA) is an endogenous lysophospholipid and a bioactive lipid that is synthesized by the enzyme autotaxin (ATX). The ATX-LPA axis has been associated with cognitive dysfunction and inflammatory diseases, ... -
Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder
Requena-Ocaña, Nerea; Araos Gómez, Pedro Fernando; Serrano-Castro, Pedro Jesús; Flores-López, María; García-Marchena, Nuria; Oliver-Martos, Begoña; Ruiz-Ruiz, Juan Jesús; Gavito, Ana L.; Pavón-Morón, Francisco Javier; Serrano, Antonia; Mayoral Cleries, Fermín; Suárez-Pérez, Juan; Rodriguez-de-Fonseca, Fernando[et al.] (IOAP-MDPI, 2023-01-07)For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced ... -
Plasma endocannabinoid alterations as a link in the comorbidity of Alzheimer's disease and type 2 diabetes mellitus.
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (2023)Over the last several years, studies have suggested a role of endocannabinoids such as 2-AG and 2-OG in the impairment of β-cell function and insulin secretion, as well as in the control of lipid and glucose metabolism in ... -
Plasma endocannabinoids as potential biomarkers of type 2 diabetes mellitus in elderly patients with mild cognitive impairment
López-Gambero, Antonio J.; Reyes, José Antonio; Fernández-Arjona, María del Mar; Rubio-Lamia, Leticia Olga; Rivera, Patricia; Serrano-Castro, Pedro Jesús; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Sociedad Española de Investigación sobre Cannabinoides (SEIC), 2022)Background: Besides their role in the nervous system and the development of cognitive impairment in elderly patients, compelling evidence suggests that endocannabinoids (ECBs) are related to motivational responses in obesity ... -
¿Por qué no preguntarle a los dientes? Un estudio en difracción de RX para la estimación del intervalo postmortem.
La determinación del Intervalo Postmortem (IPM) en etapas prolongadas es difícil de estimar con precisión. El objetivo principal de este trabajo fue estudiar la existencia de una correlación entre los cambios en la ... -
¿Por qué no preguntarle a los dientes?. Un estudio en difracción de RX para la estimación del intervalo postmortem
Rubio-Lamia, Leticia Olga; Suárez-Pérez, Juan; Santos-Amaya, Ignacio Miguel; Martín-de-las-Heras, Stella; Zapico, Sara C. (2022)La determinación del intervalo postmortem (IPM) a partir de restos mineralizados es de gran interés científico, pero también tiene importantes implicaciones legales. Aunque existen varios métodos para la estimación del IPM ... -
Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with Pappa2 Deficiency
Rubio-Lamia, Leticia Olga; Vargas, Antonio; River, Patricia; López-Gambero, Antonio J.; Tobar, Rubén; Christians, Julian K.; Martín-de-las-Heras, Stella; Rodriguez-de-Fonseca, Fernando; Chowen, Julie A.; Argente, Jesús; Suárez-Pérez, Juan[et al.] (MDPI, 2021)Deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), an IGF-1 availability regulator, causes postnatal growth failure and dysregulation of bone size and density. The present study aimed to determine the effects ... -
Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders
Flores-López, María; García-Marchena, Nuria; Araos Gómez, Pedro Fernando; Requena-Ocaña, Nerea; Porras-Perales, Oscar; Torres-Galván, Sandra; Suárez-Pérez, Juan; Pizarro Lozano, Nieves; De la Torre, Rafael; Rubio, Gabriel; Ruiz-Ruiz, Juan Jesús; Rodriguez-de-Fonseca, Fernando; Serrano, Antonia; Pavón-Morón, Francisco Javier[et al.] (IOAP-MPDI, 2022-04-30)Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder ... -
Spectrophotometric color measurement to assess temperature of exposure in cortical and medullar of heated human bones: a preliminary study
Rubio-Lamia, Leticia Olga; Díaz-Vico, Ramona; Smith-Fernández, Inés María; Smith-Fernández, José Aníbal; Suárez-Pérez, Juan; Martín-de-las-Heras, Stella; Santos-Amaya, Ignacio Miguel[et al.] (2020)Heated-bone color changes may provide information about temperature of exposure, with interest for anthropologists and forensic experts. The aim of this study was to assess heat-induced color changes by spectrophotometry ...