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Listar por autor "Jiménez-Guardeño, José Manuel"
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Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies.
Martínez-Fernández, Diana Emilia; Fernández-Quezada, David; Casillas-Muñoz, Fidel Antonio Guadalupe; Carrillo-Ballesteros, Francisco Josué; Ortega-Prieto, Ana María; Jiménez-Guardeño, José Manuel; Regla-Nava, Jose Ángel[et al.] (2023-07-18)Monkeypox virus (MPXV) is an emerging zoonotic virus that belongs to the Orthopoxvirus genus and presents clinical symptoms similar to those of smallpox, such as fever and vesicular-pustular skin lesions. However, the ... -
Immunoproteasome activation enables human TRIM5α restriction of HIV-1
Jiménez-Guardeño, José Manuel; Apolonia, Luis; Betancor, Gilberto; Malim, Michael H. (Springer Nature, 2019)Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties1. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally ... -
Interferon-stimulated genes and their antiviral activity against SARS-CoV-2.
Ortega-Prieto, Ana María; Jiménez-Guardeño, José Manuel (American Society of Microbiology, 2024)The coronavirus disease 2019 (COVID-19) pandemic remains an international health problem caused by the recent emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of May 2024, SARS-CoV-2 has ... -
Severe acute respiratory syndrome coronavirus envelope protein regulates cell stress response and apoptosis.
DeDiego, Marta L.; Nieto-Torres, José Luis; Jiménez-Guardeño, José Manuel; Regla-Nava, Jose Ángel; Álvarez, Enrique; Oliveros, Juan Carlos; Zhao, Jincun; Fett, Craig; Perlman, Stanley; Enjuanes, Luis[et al.] (PLOS, 2011)Severe acute respiratory syndrome virus (SARS-CoV) that lacks the envelope (E) gene (rSARS-CoV-ΔE) is attenuated in vivo. To identify factors that contribute to rSARS-CoV-ΔE attenuation, gene expression in cells infected ... -
TRIM5-mediated retrovirus restriction is modulated by type I interferon.
Ortega-Prieto, Ana María; Boehmer, Nina; Dinc, Hanife; Betancor, Gilberto; Petrosyan, Eduard; Malim, Michael H.; Jiménez-Guardeño, José Manuel[et al.] (2024)Since the identification in 2004 of the interferon-stimulated gene (ISG) tripartite motif-containing protein 5 α (TRIM5α) from rhesus macaques as a restriction factor preventing HIV-1 infection in these monkeys, the ...