Listar por autor "Trujillo-Estrada, Laura Isabel"
Mostrando ítems 1-20 de 48
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María
; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus.
Sánchez-Varo, Raquel María; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; De Castro, Vanessa; Jiménez, Sebastián; Ruano, Diego; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Jiménez-Lara, Antonio Jesús; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2012)
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus ... -
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease
Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura Isabel; García-Fuentes, Eduardo; Andreo-López, Juana; Sánchez-Varo, Raquel María; Gómez-Mediavilla, Ángela; López, Manuela G.; Gutiérrez, Antonia; Baglietto-Vargas, David; Garrido-Sánchez, Lourdes; García-Caballero, Melissa[et al.] (Wiley, 2023-09-01)
Adipose tissue has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in many metabolic tissues. With this regard, emerging evidence indicates ... -
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
Amyloid propagation in a sporadic model of Alzheimer disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; Cheung, Alwin; Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Núñez-Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2021-11-04)
Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Núñez-Díaz, Cristina; Forner, Stefania; Martini, Alessandra C.; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Cadete Martini, Alessandra; Gomez-Arboledas, Angela; Forner, Stefania; Rodriguez-Ortiz, Carlos; McQuade, Amanda; Danhash, Emma; Phan, Jimmy; Javoncillo, Dominic; Ha, Jordan-Vu; Tram, Melanie; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Ager, Rahasson; Davila, Jose Carlos; Kitazawa, Masashi; Blurton-Jones, Mathew; Gutierrez, Antonia; Baglietto-Vargas, David; Medeiros, Rodrigo; LaFerla, Frank M[et al.] (National Academy of Sciences, 2019-10)
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated the molecular events associated with the ... -
Animal and cellular models of Alzheimer’s disease: Progress, promise, and future approaches.
Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Sánchez-Varo, Raquel María; García-León, Juan Antonio; Nuñez-Diaz, Cristina; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; LaFerla, Frank; Moreno-González, Inés; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (SAGE, 2022-12-06)
Alzheimer’s disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms ... -
Astrocytes: From the physiology to the disease.
Trujillo-Estrada, Laura Isabel; Gómez-Arboledas, Ángela; Forner, Stefania; Cadete Martini, Alessandra; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Betham Science, 2019)
Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many ... -
Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Gómez-Arboledas, Ángela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Caracterización neuropatológica y evaluación preclínica de potenciales estrategias terapéuticas en modelos animales transgénicos de la enfermedad de Alzheimer
Trujillo-Estrada, Laura Isabel (Servicio de Publicaciones y Divulgación Científica, 2015)
La enfermedad de Alzheimer (EA), principal causa de demencia en personas mayores de 65 años, constituye uno de los problemas socio-sanitarios más importantes de nuestra época. Su etiología no es conocida y, actualmente, ... -
Co-cultures between neurons and astrocytes to address Alzheimer´s disease pathology.
Cáceres Palomo, Laura; García-León, Juan Antonio; Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Dataset seeding paper JAL.
Andreo-López, Juana; Núñez-Díaz, Cristina; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Da Cunha, Celia; Cantero-Molina, Francisco; Campos-Moreno, Cynthia; Zimbone, Stefania; Bellia, Francesco; Giuffrida, Maria Laura; Trujillo-Estrada, Laura Isabel; García-León, Juan Antonio; Bettinetti-Luque, Miriam; Gámez, Nazaret; Valdés, Catalina; Morales, Rodrigo; Forner, Stefania; Martini, Alessandra C.; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (Universidad de Málaga, 2023-11-24)
Este trabajo se centra en el estudio de la propagación de la patología amiloidea en diferentes modelos animales para la Enfermedad de Alzheimer (EA). Los resultados sugieren que existen diversos factores que modulan este ... -
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres, Manuel; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Carmona, Irene; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2012-11-22)
Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in patients and transgenic models. These dystrophies could reflect the disruption of axonal transport ... -
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Mejías-Ortega, Marina; Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno-González, Inés; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2020-03)
Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and ... -
Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ... -
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Baglietto-Vargas, David; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Gómez-Arboledas, Ángela; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2017)
Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ... -
Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.
Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Sánchez-Mejías, Elisabeth; Sánchez-Varo, Raquel María; Gómez-Arboledas, Ángela; Vizuete, Marisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2014)
The progressive cognitive decline leading to dementia in Alzheimer’s disease (AD) patients is the consequence of a severe loss of synapses and neurons affecting particular cell subpopulations in selected brain areas, with ...