Listar por autor "Trujillo Estrada, Laura"
Mostrando ítems 1-20 de 28
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María
; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabet; Jimenez, Sebastian; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gomez-Arboledas, Angela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Amyloid propagation in a sporadic model of Alzheimer disease
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Nguyen, Marie; Cheung, Alwin; Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Nuñez-Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2021-11-04)
Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Nunez-Diaz, Cristina; Forner, Stefania; Martini, Alessandra; Da Cunha, Celia; Shahnawaz, Mohammad; Soto, Claudio; Moreno-Gonzalez, Ines; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2020-12-17)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
Trujillo-Estrada, Laura Isabel; Minh Thu Nguyen, Marie; Baglietto-Vargas, David; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Moreno-Gonzalez, Ines; Soto, Claudio; Shahnawaz, Mohammad; Da Cunha, Celia; Forner, Stefania; Nunez-Diaz, Cristina; Pham Tran, Janine; Cheung, Alwin; Do Huynh, Kelly; Martinie, Alessandra C.[et al.] (Cold Spring Harbor Laboratory, 2020-12-02)
Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sanchez Mejias, Elisabeth; Mejias-Ortega, Marina; Fernández-Valenzuela, Juan José; Gomez-Arboledas, Angela; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Caracterización neuropatológica y evaluación preclínica de potenciales estrategias terapéuticas en modelos animales transgénicos de la enfermedad de Alzheimer
Trujillo-Estrada, Laura Isabel (Servicio de Publicaciones y Divulgación Científica, 2015)
La enfermedad de Alzheimer (EA), principal causa de demencia en personas mayores de 65 años, constituye uno de los problemas socio-sanitarios más importantes de nuestra época. Su etiología no es conocida y, actualmente, ... -
Co-cultures between neurons and astrocytes to address Alzheimer´s disease pathology.
Cáceres Palomo, Laura; García-León, Juan Antonio; Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabet; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura Isabel; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain
Mejias-Ortega, Marina; Sánchez-Mejías, Elisabet; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ... -
Glia and neurons from human iPSCs to address the pathology of Alzheimer´s disease
García-León, Juan Antonio; Cáceres Palomo, Laura; Trujillo Estrada, Laura; López Oliva, Elba; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
Human amyloid seeds aggregate more efficient than seeds from old 3xtg-ad mice
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Huynh, Kelly; Thu Nguyen, Marie Minh; Cheung, Alwin; Tran, Janine Pham; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Nuñez-Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2022)
Aims: Most age-associated neurodegenerative disorders involve the aggregation of specific proteins within the nervous system, as occurs in Alzheimer’s disease (AD). Recent evidence indicates that Aβ can misfold and aggregate ... -
Human and mouse seeds differentially affect AB aggregation by modulating the inflammatory response.
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Da Cunha, Celia; Morales-Cabello, Mario; Fatuarte Juli, Ivan; Trujillo-Estrada, Laura Isabel; Núñez Díaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2023)
Abstract text: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prionlike process. These amyloid aggregation ... -
Human and mouse seeds differentially affect Aβ aggregation by modulating the inflammatory response
Andreo-López, Juana; Cantero-Molina, Francisco; Bettinetti-Luque, Miriam; Do Huynh, Kelly; Minh Thu Nguyen, Marie; Cheung, Alwin; Pham Tran, Janine; Da Cunha, Celia; Trujillo-Estrada, Laura Isabel; Nuñez Diaz, Cristina; Cadete-Martini, Alessandra; Forner, Stefania; Gutiérrez-Pérez, Antonia; LaFerla, Frank; Baglietto-Vargas, David[et al.] (2023)
Background: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. These amyloid aggregation ... -
Impact of white adipose tissue in AD pathology
Bettinetti-Luque, Miriam; Andreo-López, Juana; Cantero-Molina, Francisco; Trujillo-Estrada, Laura Isabel; Rodriguez-Ortiz, Carlos J; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2021-11-04)
Introduction: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ... -
Impact of white adipose tissue in AD pathology
Bettinetti-Luque, Miriam; Trujillo-Estrada, Laura Isabel; Andreo-López, Juana; Cantero-Molina, Francisco; Rodriguez-Ortiz, Carlos J; LaFerla, Frank; Gutiérrez-Pérez, Antonia; Baglietto-Vargas, David[et al.] (2022)
Aims: Alzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences has suggested that metabolic alterations are an important ... -
Involvement of different aβ-associated myeloid populations in the human alzheimer’s brain
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabet; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Parenchymal microglia, the brain-resident immune cells, have been postulated as a critical factor in Alzheimer´s disease (AD) since the identification of genetic risk factors related to their functions. Though the role of ... -
Lithium, as a neuroprotective therapy for Alzheimer’s disease pathology, modifies abeta plaque toxicity
Trujillo-Estrada, Laura Isabel; De Castro Carratalá, Vanessa; Jimenez, Sebastian; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabet; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2014-07-02)
BACKGROUND: Despite the relatively large information about the Alzheimer’s disease (AD) pathology, no effective disease-modifying treatment has been yet developed. Lithium, a primary drug to treat bipolar disorder, has ... -
LITIO COMO TERAPIA NEUROPROTECTORA EN EL MODELO APPSL/PS1M146L DE LA ENFERMEDAD DE ALZHEIMER
Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno González, Inés; De Castro Carratalá, Vanessa; Jimenez, Sebastian; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabet; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2013)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). ... -
Mitochondrial ultrastructural defects in reactive astrocytes of Alzheimer's mice hippocampus.
Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Fernández-Valenzuela, Juan José; Sánchez-Mejías, Elisabet; Mejías-Ortega, Marina; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is a complex neurodegenerative condition that causes progressive memory loss and dementia. In AD brains astrocyte become reactive potentially contributing to cognitive decline. Astrocyte reactivity ... -
Monocyte-derived cells invade amyloid plaques in human alzheimer’s disease hippocampus.
Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabet; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ...