Listar por autor "Alba-Conejo, Emilio"
Mostrando ítems 1-20 de 40
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A Carboxylesterase 2 Gene Polymorphism as Predictor of Capecitabine on Response and Time to Progression
Ribelles, Nuria; López-Siles, J; Sánchez-Muñoz, Alfonso
; Sánchez, E; González, E; Sánchez, MJ; Carabantes, F; Sánchez- Rovira, P; Márquez, A; Dueñas, R; Sevilla, I; Alba-Conejo, Emilio[et al.] (Bentham Science Publishers Ltd, 2008)
Capecitabine is a drug that requires the consecutive action of three enzymes: carboxylesterase 2 (CES 2), cytidine deaminase (CDD), and thymidine phosphorylase (TP) for transformation into 5-fluorouracil (5FU). The ... -
A microRNA signature associated with early recurrence in breast cancer.
Pérez-Rivas, Luis G.; Jerez-Aragonés, José Manuel; Carmona, Rosario; De Luque, Vanessa; Vicioso-Recio, Luis Prudencio; Claros-Díaz, Manuel Gonzalo; Viguera-Mínguez, Enrique; Pajares, Bella; Sánchez-Muñoz, Alfonso; Ribelles, Nuria; Alba-Conejo, Emilio; Lozano-Castro, José[et al.] (PLOS, 2014-03-14)
Recurrent breast cancer occurring after the initial treatment is associated with poor outcome. A bimodal relapse pattern after surgery for primary tumor has been described with peaks of early and late recurrence occurring ... -
A randomized phase II trial of platinum salts in basal-like breast cancer patients in the neoadjuvant setting. Results from the GEICAM/2006-03, multicenter study
Alba-Conejo, Emilio; Chacón, J. L.; Lluc, A.; Antón, A.; Estévez, L.; Cirauqui, B.; Carrasco, E.; Calvo, L.; Seguí, M.A.; Ribelles, Nuria; Álvarez, R.; Sánchez-Muñoz, Alfonso; Sánchez, R.; Lopez Garcia-Asenjo, J.A.; Rodriguez-Martin, C.; Escudero, M.J.; Albanell, J.[et al.] (Springer, 2012-10)
Abstract Chemotherapy remains as the only systemic treatment option available for basal-like breast cancer (BC) patients. Preclinical models and several phase II studies suggested that platinum salts are active drugs in ... -
Association of Circular RNA and Long Non-Coding RNA Dysregulation with the Clinical Response to Immune Checkpoint Blockade in Cutaneous Metastatic Melanoma.
Oliver, Javier; Onieva Zafra, Juan Luis; Garrido-Barros, María; Berciano-Guerrero, Miguel Ángel; Sánchez-Muñoz, Alfonso; Lozano, María José; Farngren, Angela; Álvarez-Pérez, Martina; Martínez-Gálvez, Beatriz; Pérez-Ruiz, Elisabeth; Alba-Conejo, Emilio; Cobo Dols, Manuel Ángel; Rueda-Domínguez, Antonio; Barragán, Isabel[et al.] (MDPI, 2022)
Cutaneous melanoma (CM) is the most lethal form of skin cancer if it becomes metastatic, where treatment options and survival chances decrease dramatically. Immunotherapy treatments based on the immunologic checkpoint ... -
Bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer
Sánchez-Muñoz, Alfonso; Mendiola, César; Pérez-Ruiz, Elisabeth; Rodríguez-Sánchez, César A.; Jurado, José Miguel; Alonso-Carrión, Lorenzo Javier; Ghanem, Ismael; Velasco, Guillermo de; Quero-Blanco, Cristina; Alba-Conejo, Emilio[et al.] (KARGER, 2010-11)
Aim: To retrospectively assess the efficacy and safety of bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer. Patients and Methods: Patients with recurrent ... -
Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index
Cuesta-Vargas, Antonio; Buchan, Jena; Pajares, Bella; Alba-Conejo, Emilio; Roldán-Jiménez, Cristina (Public Library of Science, 2019-04-22)
Although breast cancer mortality is decreasing, morbidity following treatment remains a significant issue, as patients face symptoms such as cancer-related fatigue (CRF). The aim of the present study is to develop a ... -
Clinical text classification in Cancer Real-World Data in Spanish
Moreno-Barea, Francisco J.; Mesa, Héctor; Ribelles, Nuria; Alba-Conejo, Emilio; Jerez-Aragonés, José Manuel (2023-06-29)
Healthcare systems currently store a large amount of clinical data, mostly unstructured textual information, such as electronic health records (EHRs). Manually extracting valuable information from these documents is costly ... -
Deciphering breast cancer intertumor heterogeneity: tumor subtyping and analysis of germline genetic variants
(UMA Editorial, 2018-07)INTRODUCCIÓN: El cáncer de mama no es una única enfermedad, sino un conjunto de enfermedades que presentan una gran variabilidad en todos sus componentes: características histopatológicas, respuesta al tratamiento y ... -
Deciphering HER2 Breast Cancer Disease: Biological and Clinical Implications.
Godoy-Ortiz, Ana; Sánchez-Muñoz, Alfonso; Chica Parrado, María del Rosario; Álvarez-Pérez, Martína; Ribelles, Nuria; Rueda-Domínguez, Antonio; Alba-Conejo, Emilio[et al.] (Frontiers Media, 2019)
The main obstacle for designing effective treatment approaches in breast cancer is the extensive and the characteristic heterogeneity of this tumor. The vast majority of critical genomic changes occurs during breast cancer ... -
Detection of tumor morphology mentions in clinical reports in Spanish using transformers
López-García, Guillermo; Jerez-Aragonés, José Manuel; Ribelles, Nuria; Alba-Conejo, Emilio; Veredas-Navarro, Francisco Javier (Springer, 2021)
The aim of this study is to systematically examine the performance of transformer-based models for the detection of tumor morphology mentions in clinical documents in Spanish. For this purpose, we analyzed 3 transformer ... -
Development of a Novel NGS Methodology for Ultrasensitive Circulating Tumor DNA Detection as a Tool for Early-Stage Breast Cancer Diagnosis
Jiménez-Rodríguez, Begoña; Alba-Bernal, Alfonso; López-López, Esperanza; Quirós-Ortega, María Elena; Carbajosa, Guillermo; Garrido-Aranda, Alicia; Álvarez-Pérez, Martína; Godoy-Ortiz, Ana; Queipo-Ortuño, María Isabel; Vicioso-Recio, Luis Prudencio; Díaz-Córdoba, Gema; Roldán-Díaz, María Dunia; Velasco-Suelto, Jesús; Hernando Melia, Cristina; Bermejo, Begoña; Julve-Parreño, Ana; Lluch, Ana; Pascual, Javier; Comino-Méndez, Iñaki; Alba-Conejo, Emilio[et al.] (IOAP-MDPI, 2022-12-21)
Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. Herein, we developed a novel ultrasensitive pipeline to detect circulating ... -
Different Pathological Complete Response Rates According to PAM50 Subtype in HER2+ Breast Cancer Patients Treated With Neoadjuvant Pertuzumab/Trastuzumab vs. Trastuzumab Plus Standard Chemotherapy: An Analysis of Real-World Data.
Díaz-Redondo, Tamara; Lavado Valenzuela, Rocío; Jiménez-Rodríguez, Begoña; Pascual, Tomás; Gálvez, Fernando; Falcón, Alejandro; Álamo, María del Carmen; Morales-Estévez, Cristina; Amerigo, Marta; Pascual, Javier; Sánchez-Muñoz, Alfonso; González-Guerrero, Macarena; Vicioso-Recio, Luis Prudencio; Laborda-Illanes, Aurora; Ortega-Jiménez, María Victoria; Pérez-Villa, Lidia; Fernández-Martínez, Aranzazu; Chic, Nuria; Jerez-Aragonés, José Manuel; Álvarez-Pérez, Martína; Prat, Aleix; Ribelles, Nuria; Alba-Conejo, Emilio[et al.] (Frontiers Media, 2019)
Double blockade with pertuzumab and trastuzumab combined with chemotherapy is the standard neoadjuvant treatment for HER2-positive early breast cancer. Data derived from clinical trials indicates that the response rates ... -
Efecto de la quimioterapia neoadyuvante en la variación de receptores hormonales, Her2 y Ki67 en pacientes con cáncer de mama
Álvarez-Pérez, Martína; Lavado-Fernández, Ana Isabel; Pérez-Villa, Lidia; Lozano, María José; Jiménez-Rodríguez, Begoña; De Luque, Vanessa; Jiménez-Vista, Álvaro; Ventura, Carmen; Jiménez-Fernández, Ana; Rodrigo-Fernández, Isabel; Ramírez-Tortosa, César; Ribelles, Nuria; Alba-Conejo, Emilio; Vicioso-Recio, Luis Prudencio[et al.] (2016-03-02)
Introducción:Existe controversia respecto al impacto de la quimioterapia en la expresión de marcadores inmunohistoquímicos del cáncer de mama, ya que pueden existir cambios en los marcadores tumorales entre las biopsias ... -
Estudio de factores predictivos de respuesta patológica a quimioterapia neoadyuvante en el cáncer de mama receptores hormonales positivos HER2 negativo
Lavado-Fernández, Ana Isabel; Álvarez-Pérez, Martína; Prieto Cuadra, Juan Daniel; Jiménez-Rodríguez, Begoña; Lozano, María José; De Luque, Vanessa; Jiménez-Vista, Álvaro; Ventura, Carmen; Jiménez-Fernández, Ana; Rodrigo, Isabel; Ramírez, César; Cano, Tatiana; González-Zafra, Virginia; Pérez-Villa, Lidia; Gallego-Domínguez, Elena María; Ortega-Jiménez, María Victoria; Arranz-Salas, Isabel María; Ribelles, Nuria; Alba-Conejo, Emilio; Vicioso-Recio, Luis Prudencio[et al.] (2015-07-02)
La quimioterapia neoadyuvante (QTN) se utiliza cada vez más para conseguir una reducción tumoral que permita una cirugía conservadora y, mediante el grado de respuesta patológica tumoral, determinar el pronóstico de las ... -
Explainable clinical coding with in-domain adapted transformers
López-García, Guillermo; Jerez-Aragonés, José Manuel; Ribelles, Nuria; Alba-Conejo, Emilio; Veredas-Navarro, Francisco Javier (Elsevier, 2023)
Background and Objective: Automatic clinical coding is a crucial task in the process of extracting relevant in-formation from unstructured medical documents contained in Electronic Health Records (EHR). However, most of ... -
Forearm Muscle Activity During the Handgrip Test in Breast Cancer Survivors: A Cross-Sectional Study
Fuentes-Abolafio, Iván José; Roldán-Jiménez, Cristina; Iglesias-Campos, Marcos; Pajares-Hachero, Bella I.; Alba-Conejo, Emilio; Cuesta-Vargas, Antonio[et al.] (Elsevier, 2023)
We recruited 102 breast cancer survivors at a secondary care in Malaga. Included breast cancer survivors showed a good upper limb functionality but a reduced forearm muscle activity. Forearm muscle activity showed a poor ... -
High IGKC-Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint Blockade.
Onieva Zafra, Juan Luis; Xiao, Qingyang; Berciano-Guerrero, Miguel Ángel; Laborda-Illanes, Aurora; de Andrea, Carlos; Chaves, Patricia; Piñeiro Pereda, María del Pilar; Garrido-Aranda, Alicia; Gallego-Domínguez, Elena María; Sojo, Belén; Gálvez Carvajal, Laura; Chica Parrado, María del Rosario; Prieto Cuadra, Juan Daniel; Pérez-Ruiz, Elisabeth; Farngren, Angela; Lozano, María José; Álvarez-Pérez, Martína; Jiménez, Pedro; Sánchez-Muñoz, Alfonso; Oliver, Javier; Cobo Dols, Manuel Ángel; Alba-Conejo, Emilio; Barragán, Isabel[et al.] (MDPI, 2022)
Resistance to Immune Checkpoint Blockade (ICB) constitutes the current limiting factor for the optimal implementation of this novel therapy, which otherwise demonstrates durable responses with acceptable toxicity scores. ... -
Identificación de una firma de expresión génica mediante el sistema de análisis nCounter como marcador pronóstico de recaída en pacientes con tumores de células germinales no seminoma estadio I
(UMA Editorial, 2020-09-16)INTRODUCCIÓN Actualmente para el 15-20% de los pacientes con tumores de células germinales (TCG) mestastásicos las opciones curativas son limitadas, estando en investigación la respuesta a terapias diana. La infiltración ... -
Inertial Sensors Embedded in Smartphones as a Tool for Fatigue Assessment Based on Acceleration in Survivors of Breast Cancer.
Cuesta-Vargas, Antonio; Pajares, Bella; Trinidad-Fernández, Manuel; Alba-Conejo, Emilio; Roldán-Jiménez, Cristina (OXFORD UNIV PRESS INC, 2020)
Background. Cancer-related fatigue is a symptom commonly reported in survivors of breast cancer and is the most variable symptom. Besides questionnaires like PIPER to assess cancer-related fatigue, there is a need to ... -
Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer.
Sánchez-Muñoz, Alfonso; Gallego-Domínguez, Elena María; De Luque, Vanessa; Pérez-Rivas, Luis G.; Vicioso-Recio, Luis Prudencio; Ribelles, Nuria; Lozano-Castro, José; Alba-Conejo, Emilio[et al.] (Springer Nature, 2010-04-13)
Background: Mutational analysis of the KRAS gene has recently been established as a complementary in vitro diagnostic tool for the identification of patients with colorectal cancer who will not benefit from anti-epidermal ...