Listar por autor "Lechuga-Sancho, Alfonso María"

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Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

González-Domínguez, Álvaro; Belmonte, Thalía; Domínguez-Riscat, Jesús; Ruíz-Ocaña, Pablo; Muela-Zarzuela, Inés; Saez-Benito, Ana; Montañez, Raúl; Mateos, Rosa María; Lechuga-Sancho, Alfonso María[et al.] (Springer Nature, 2023-08-20)

Background: Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no ...
VUS next in rare diseases? Deciphering genetic determinants of biomolecular condensation

Heredia-Torrejón, María; Montañez, Raúl; González-Menese, Antonio; Carcavilla, Atilano; Lechuga-Sancho, Alfonso María; Medina, Miguel Ángel[et al.] (BioMed Central, 2024-09-06)

The diagnostic odysseys for rare disease patients are getting shorter as next-generation sequencing becomes more widespread. However, the complex genetic diversity and factors influencing expressivity continue to challenge ...