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Aggregate-Depleted Brain Fails to Induce Ab Deposition in a Mouse Model of Alzheimer’s Disease.
Duran-Aniotz, Claudia; Morales, Rodrigo; Moreno-González, Inés; Hu, Ping Ping; Fedynyshyn, Joseph; Soto, Claudio[et al.] (PLOS, 2014-02-12)Recent studies in animal models of Alzheimer’s disease (AD) show that amyloid-beta (Ab) misfolding can be transmissible; however, the mechanisms by which this process occurs have not been fully explored. The goal of this ... -
Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo.
Duran-Aniotz, Claudia; Morales, Rodrigo; Moreno-González, Inés; Hu, Ping Ping; Soto, Claudio (BMC, 2013-11-18)Background: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidosis ...