- RIUMA Principal
- Listar por autor
Listar por autor "Sanchez-Varo, Raquel"
Mostrando ítems 1-12 de 12
-
Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sanchez-Varo, Raquel; De Castro, Vanessa; Trujillo-Estrada, Laura; Sanchez-Mejias, Elisabeth; Jimenez, Sebastian; [et al.] (2017-10-02)We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sanchez-Mejias, Elisabeth; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura; Sanchez-Varo, Raquel; [et al.] (2020-12-16)Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
Fernandez-Valenzuela, Juan Jose (UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sanchez-Mejias, Elisabeth; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; [et al.] (2019-07-18)The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabeth; [et al.] (2018-07-20)AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan Jose; Romero-Molina, Carmen; Sanchez-Mejias, Elisabeth; Gomez-Arboledas, Angela; [et al.] (2019-07-19)Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice
Ferbandez-Valenzuela, Juan Jose; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco; Vizuete, Marisa; [et al.] (2016-09-09)AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ... -
Lithium, as a neuroprotective therapy for Alzheimer’s disease pathology, modifies abeta plaque toxicity
Trujillo-Estrada, Laura; De Castro, Vanesa; Jimenez, S; Sanchez-Varo, Raquel; Sanchez-Mejias, Elisabet; [et al.] (2014-07-02)BACKGROUND: Despite the relatively large information about the Alzheimer’s disease (AD) pathology, no effective disease-modifying treatment has been yet developed. Lithium, a primary drug to treat bipolar disorder, has ... -
Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
Sanchez-Mejias, Elisabeth; Navarro, Victoria; Nuñez-Diaz, Cristina; Jiménez, Sebastián; Sanchez-Varo, Raquel; [et al.] (2018-07-20)Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabeth; Navarro, Victoria; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; [et al.] (2019-07-17)The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; De Castro, Vanessa; Sanchez-Mejias, Elisabeth; Nuñez-Diaz, Cristina; [et al.] (2020-12-17)Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
SYSTEMIC ADMINISTRATION OF EPOTHYLONE-D RECUES MEMORY AND AMELIORATES ALZHEIMER’S DISEASE-LIKE PATHOLOGY IN APP/PS1 MICE
Fernandez-Valenzuela, Juan José; Sanchez-Varo, Raquel; De Castro, Vanessa; Moyano, Francisco José; Vizuete, Marisa; [et al.] (2017-04-17)Aims Cognitive and memory decline in Alzheimer's disease (AD) patients is highly related to synaptic dysfunction and neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure, ...