Listar por autor "Cifuentes-Rueda, Manuel"
Mostrando ítems 1-20 de 30
-
A collagen-targeted biomimetic RGD peptide to promote osteogenesis
Visser, Rick
; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Becerra-Ratia, José; Cifuentes-Rueda, Manuel[et al.] (MARY ANN LIEBERT, INC, 2014-01)
Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of ... -
A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Mateos-Grondona, Jesús; Rodriguez-de-Fonseca, Fernando; López-Ávalos, María Dolores[et al.] (2014-07-14)
Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (2013-11-27)
RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages
Saldivia, Natalia; Salazar, Katterine; Cifuentes-Rueda, Manuel; Espinoza, F; Harrison, FE; Nualart, Francisco[et al.] (Wiley, 2024-04)
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of ... -
Ascorbic acid and its transporter SVCT2, affect radial glia cells differentiation in postnatal stages
Saldivia, Natalia; Salazar, Katterine; Cifuentes-Rueda, Manuel; Espinoza, Francisca; Harrison, Fiona E.; Nualart, Francisco[et al.] (Wiley, 2024-01-05)
Radial glia (RG) cells generate neurons and glial cells that make up the cerebral cortex. Both in rodents and humans, these stem cells remain for a specific time after birth, named late radial glia (lRG). The knowledge of ... -
Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Ulloa, Viviana; Saldivia, Natalia; Ferrada, Luciano; Salazar, Katherine; Martínez, Fernando; Silva-Álvarez, Carmen; Magdalena, Rocío; Oviedo, María José; Montecinos, Hernán; Torres-Vergara, Pablo; Cifuentes-Rueda, Manuel; Nualart, Francisco[et al.] (Springer Nature, 2019-10)
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the vitamin C transporter, SVCT2, has ... -
Basic fibroblast growth factor enhances the osteogenic differentiation induced by bone morphogenetic protein-6 in vitro and in vivo
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (ELSEVIER, 2012-04)
Some members of the bone morphogenetic protein subfamily (BMP-2 and -7) are currently used in orthopedic surgery for several applications. Although their use is considered safe at short term, the high doses of growth factors ... -
Bone marrow mesenchymal stem cells, collagen scaffold and BMP-2 for rat spinal fusio
Arrabal-García, Pilar María; Visser, Rick; Cifuentes-Rueda, Manuel; Becerra-Ratia, José; Jiménez-Enjuto, E. (2013-11-08)
The use of autograft for posterolateral spinal fusion, continue being considered the gold standard for the treatment of spine pathologies. However, due to complications such as donor site morbidity, increased operating ... -
Bone marrow-derived mesenchymal stem cells characterization and transplantation in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Santos-Ruiz, Leonor; Shumilov, Kirill; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús[et al.] (2015-10-08)
Congenital hydrocephalus is a disorder presenting a degeneration of the periventricular cerebral parenchyma and the white matter, which causes significant mortality and life-long neurological complications. There are ... -
Brain Glucose-Sensing Mechanism and Energy Homeostasis.
López-Gambero, Antonio Jesús; Martínez, Fernando; Salazar, Katty; Cifuentes-Rueda, Manuel; Nualart, Francisco (Springer Nature, 2019)
The metabolic and energy state of the organism depends largely on the availability of substrates, such as glucose for ATP production, necessary for maintaining physiological functions. Deregulation in glucose levels leads ... -
Characterization and administration of bone marrow-derived mesenchymal stem cells in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes-Rueda, Manuel; Ho-Plágaro, Ailec; Shumilov, Kirill; Santos-Ruiz, Leonor; Pérez-Fígares, José Manuel; Jiménez-Lara, Antonio Jesús[et al.] (2015-07-08)
Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool in neurodegenerative diseases, due to their ability to migrate to degenerated tissues and the production of growth factors. ... -
Comparative analysis and characterization of soluble factors and exosomes from cultured adipose tissue and bone marrow mesenchymal stem cells in canine species
Villatoro, Antonio J; Alcoholado Cueto, Cristina; Martín Astorga, María del Carmen; Fernández, V.; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (Elsevier, 2019-02)
The two main sources of mesenchymal stem cell (MSCs) in the canine species are bone marrow (cBM-MSCs) and adipose tissue (cAd-MSCs). The secretion of multitude bioactive molecules, included under the concept of secretome ... -
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Forman, Katherine; Martínez, Fernando; Cifuentes-Rueda, Manuel; Fernández, Marcos; Bertinar, Romina; Torres, Pablo; Salazar, Katherine; Godoy, Alejandro; Nualart, Francisco[et al.] (Wiley, 2020-12)
Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica Ferrández, Javier; García-Martín, María Luisa; Muñoz, Carmen; Jiménez, Sebastián; Navarro, Victoria; García-Cuervo, Luisa; Cifuentes-Rueda, Manuel; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Guitérrez, Antonia; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (2017-06-28)
Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
Nualart, Francisco; Cifuentes-Rueda, Manuel; Ramírez, Eder; Martínez, Fernando; Barahona, M José; Ferrada, Luciano; Saldivia, N; Borgonzone, Ernesto R; Thorens, B; Salazar, Katterine[et al.] (Public Library of Science, 2023-09)
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes-Rueda, Manuel; Mateos-Grondona, Jesús; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)
Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
Baeza, Víctor; Cifuentes-Rueda, Manuel; Martínez, Fernando; Ramírez, Eder; Nualart, Francisco; Ferrada, Luciano; Oviedo, María José; De Lima, Isabelle; Troncoso, Ninoschka; Saldivia, Natalia; Salazar, Katty[et al.] (Springer Nature, 2021)
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such ... -
Insights into the effects of polygalacturonase FaPG1 gene silencing on pectin matrix disassembly, enhanced tissue integrity, and firmness in ripe strawberry fruits,
Posé-Albacete, Sara; Paniagua, Candelas; Cifuentes-Rueda, Manuel; Blanco-Portales, Rosario; Mercado-Carmona, José Ángel (Oxford Academy, 2013-07-19)
Este estudio examina el impacto de la reducción del gen FaPG1 en fresas, que se ha relacionado con la disminución del reblandecimiento de la fruta y la prolongación de la vida útil postcosecha. Se encontró que las fresas ... -
Is IIIG9 a New Protein with Exclusive Ciliary Function? Analysis of Its Potential Role in Cancer and Other Pathologies
Oviedo, MJ; Ramírez, E; Cifuentes-Rueda, Manuel; Farkas, Carlos; Mella, Andy; Bertinat, Romina; Gajardo, Roberto; Ferrada, Luciano; Jara, Nery; De lima, Isabelle; Martínez, Fernando; Nualart, Francisco; Salazar, Katerine[et al.] (MDPI, 2022-10)
The identification of new proteins that regulate the function of one of the main cellular phosphatases, protein phosphatase 1 (PP1), is essential to find possible pharmacological targets to alter phosphatase function in ... -
LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance.
Moreno-Fernández, R.; Rosell-del-Valle, Cristina; Bacq, Alexandre; Zanoletti, Olivia; Cifuentes-Rueda, Manuel; Pérez-Martín, Margarita; Gavito, Ana L.; García-Fernández, María Inmaculada; Estivill-Torrús, Guillermo; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Sandi, Carmen; Pedraza-Benítez, María del Carmen[et al.] (Neuropharmacology, 2020-03-01)
The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. Current data suggest that the ...