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Listar por autor "Cifuentes, Manuel"
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A model of neuroinflammation and demyelination by intracerebroventricular injection of microbial neuraminidase
Fernández-Llebrez, Pedro; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; Cifuentes, Manuel; Pérez-Martín, Margarita; [et al.] (2014-07-14)Neuraminidase from Clostridium perfringens, which cleaves terminal sialic acid from carbohydrate chains, was injected in the lateral ventricle of rats. It diffused in the ipsilateral ventricle, the third ventricle, and ... -
A synthetic collagen-binding arg-gly-asp (rgd) biomimetic peptide enhances bone cell differentiation
Visser, Rick; Arrabal, Pilar M.; Santos-Ruiz, Leonor; Fernández-Barranco, Raúl; Cifuentes, Manuel; [et al.] (2013-11-27)RGD (arginine-glycine-aspartic acid) peptides have shown some promising abilities to promote the attachment of cells to biomaterials and to direct their differentiation. However, anchoring these peptides to the biomaterial’s ... -
Bone marrow mesenchymal stem cells, collagen scaffold and BMP-2 for rat spinal fusio
Arrabal, Pilar M.; Visser, R.; Cifuentes, Manuel; Becerra-Ratia, Jose; Jiménez-Enjuto, E. (2013-11-08)The use of autograft for posterolateral spinal fusion, continue being considered the gold standard for the treatment of spine pathologies. However, due to complications such as donor site morbidity, increased operating ... -
Bone marrow-derived mesenchymal stem cells characterization and transplantation in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes, Manuel; Ho-Plagaro, Ailec; Santos-Ruiz, Leonor; Shumilov, Kirill; [et al.] (2015-10-08)Congenital hydrocephalus is a disorder presenting a degeneration of the periventricular cerebral parenchyma and the white matter, which causes significant mortality and life-long neurological complications. There are ... -
Characterization and administration of bone marrow-derived mesenchymal stem cells in an animal model of congenital hydrocephalus
García-Bonilla, María; Cifuentes, Manuel; Ho-Plagaro, Ailec; Shumilov, Kirill; Santos-Ruiz, Leonor; [et al.] (2015-07-08)Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool in neurodegenerative diseases, due to their ability to migrate to degenerated tissues and the production of growth factors. ... -
Effect of bone marrow-derived mesenchymal stem cells on congenital hydrocephalus in the hyh mouse
García-Bonilla, María; Shumilov, Kirill; Vitorica, Javier; García-Martín, María Luisa; Muñoz, Carmen; [et al.] (2017-06-28)Background Bone marrow-derived mesenchymal stem cells (BM-MSC) are considered as a potential therapeutic tool for neurodegenerative diseases due to their ability for migrating into damaged tissue. Additionally, these cells ... -
IGF-I stimulates cell proliferation in a specific area of the hypothalamic wall
Pérez-Martín, Margarita; Cifuentes, Manuel; Grondona JM; López-Ávalos, María Dolores; Fernández-Llebrez, Pedro (2015-09-15)Neurogenesis in the adult rat hippocampal subgranular zone and the subventricular zone of the lateral ventricles has been well documented. Increasing evidence suggests that neurogenesis also occurs in the adult hypothalamus. ... -
Stress, depression and the hippocampus: modulatory effects of continuous LPA treatment
Moreno-Fernández, Román; Bacq, Alexandre; Rosell-Valle, Crisitina; Zanoletti, Olivia; Cifuentes, Manuel; [et al.] (2019-06-25)The LPA1, one of the six characterized G protein-coupled receptors (LPA1–6) through which lysophosphatidic acid acts may be involved in promoting normal emotional behaviors. Evidence also imply a role for the LPA1 receptor ... -
The effect of combining bone morphogenetic proteins -2 and -6 on osteoblastic differentiation and bone
Rico-Llanos, Gustavo; Bodnárová, Kristina; Arrabal, Pilar M.; Cifuentes, Manuel; Becerra-Ratia, Jose (2015-07-21)Bone morphogenetic proteins-2 and -7 (BMP-2 and -7) are the only two members of the BMP subfamily approved to date to be used in combination with collagen type I in orthopedic surgery, although other BMPs have proven to ... -
The ependymal detach due to neuraminidase provokes hydrocephalus
Fernández-Arjona, María del Mar; Granados-Durán, Pablo; Gómez-Roldán, María del Carmen; López-Ávalos, María Dolores; Grondona, Jesús M; [et al.] (2015-05-27)Background: In many cases there seems to exist a tight relationship between the integrity of the ependymal barrier and the onset of hydrocephalus (see 1). We wanted to investigate this by means of a repetitive model that ...