Listar por autor "Claros-Díaz, Manuel Gonzalo"
Mostrando ítems 1-20 de 25
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A microRNA signature associated with early recurrence in breast cancer.
Pérez-Rivas, Luis G.; Jerez-Aragonés, José Manuel
; Carmona, Rosario; De Luque, Vanessa; Vicioso-Recio, Luis Prudencio; Claros-Díaz, Manuel Gonzalo; Viguera-Mínguez, Enrique; Pajares, Bella; Sánchez-Muñoz, Alfonso; Ribelles, Nuria; Alba-Conejo, Emilio; Lozano-Castro, José[et al.] (PLOS, 2014-03-14)
Recurrent breast cancer occurring after the initial treatment is associated with poor outcome. A bimodal relapse pattern after surgery for primary tumor has been described with peaks of early and late recurrence occurring ... -
A workflow with dedicated tools for preparing reference transcriptomes from non-model organisms has evidenced important biological information
Claros-Díaz, Manuel Gonzalo; Benzekri, Hicham; Seoane, Pedro; Carmona Muñoz, Rosario Maria; Bautista-Moreno, Rocío; Guerrero-Fernández, Darío; Fernández-Pozo, Noé[et al.] (2014-10-01)
Construction transcriptomes of non-model organisms is a common task nowadays due to the advent of low-cost sequencing platforms. The non-model organisms require a de novo assembling strategy since no reference is available. ... -
Análisis Bioinformático del Transcriptoma del Pino
(UMA Editorial, 2021-09-17)Las especies del género Pinus son de gran interés económico y ecológico en todo el mundo, y especialmente en el hemisferio norte. Sin embargo estas especies carecen de un genoma secuenciado debido a la complejidad y los ... -
Analysis of hypervariable DNA sequences by NGS technologies: QuasiFlow
Viguera-Mínguez, Enrique; Díaz-Martínez, Luis; Grande-Pérez, Ana; Claros-Díaz, Manuel Gonzalo; Seoane Zonjic, Pedro (2016-11-14)
The development of Next Generation Sequencing (NGS) technologies has allowed deep characterization of highly variable sequences such as viral or mitochondrial genomes. With respect to RNA and ssDNA viruses, their low ... -
Analysis of viral quasispecies by NGS technologies: quasiflow
Díaz-Martínez, Luis; Seoane Zonjic, Pedro; Claros-Díaz, Manuel Gonzalo; Viguera-Mínguez, Enrique; Grande-Pérez, Ana (Sociedad Española de Virología, 2017)
We have developed QuasiFlow, a workflow designed in AutoFlow that takes advantage of NGS technologies to reconstruct quasispecies based in Illumina reads. QuasiFlow characterises and computes several key parameters, such ... -
Bioinformatic analyses of olive pollen tube and seed transcriptomes and their integration in an interactive olive expression atlas
Bullones, Amanda; Fernández-Pozo, Noé; Lima-Cabello, Elena; Castro, Antonio Jesús; Alché-Ramírez, Juan de Dios; Claros-Díaz, Manuel Gonzalo[et al.] (2022)
The olive tree (Olea europaea L.) is of great socioeconomic importance due to the production of oil and table olives, and the seed is also an emergent source of nutraceuticals (Jiménez-Ruiz et al., 2020) and feed supplements ... -
Biomarcadores de cáncer de pulmón basados en la expresión de genes, transportes y secuencias repetitivas.
(UMA Editorial, 2020-02-21)Uno de los grandes avances terapéuticos es la medicina personalizada, que se basa en biomarcadores que ayudan en la filiación y elección del tratamiento. La mayoría de los biomarcadores se basan en variaciones génicas y ... -
Biomarker potential of repetitive-element transcriptome in lung cancer
Claros-Díaz, Manuel Gonzalo; Arroyo, Macarena; Bautista-Moreno, Rocío; Larrosa-Jiménez, Rafael; Cobo, Manuel Ángel (PeerJ, 2019)
Since repetitive elements (REs) account for nearly 53% of the human genome, profiling its transcription after an oncogenic change might help in the search for new biomarkers. Lung cancer was selected as target since it is ... -
Comparative bioinformatic analysis by RNA-seq of patients from Regional Hospital of Malaga with two types of lung cancer
(2021-07-15)Differentially genes expressed were identified using iDEP tool. A total of 4513 DEGs were identified in LUAD and 5369 in LUSC. The upregulated and downregulated genes were applied to analyze the GO: biological process, ... -
Construction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsies
Espinosa García, Elena María; Arroyo Varela, Macarena; Larrosa-Jiménez, Rafael; Gómez‑Maldonado, Josefa; Cobo Dols, Manuel Ángel; Claros-Díaz, Manuel Gonzalo; Bautista-Moreno, Rocío[et al.] (Springer Nature, 2022-10-12)
Lung cancer (LC) is the most common cause of cancer death worldwide mostly due to the low survival rate: 75% of cases are identified in advanced stages. In this study, the list of useful biomarkers to make an early diagnosis ... -
Creación y uso de los flujos de trabajo bioinformáticos
(UMA Editorial, 2016)En el año 2012 comencé mi doctorado en el Departamento de Biología Molecular y Bioquímica, aunque alojado en la Plataforma Andaluza de Bioinformática (PAB), emplazado en el edificio de Supercomputación y Bioinnovación sito ... -
Estudio bioinformático del transcriptoma reproductivo de olivo (Olea europaea L.) y aplicaciones
(UMA Editorial, 2021)El olivo (Olea europaea L.) es una planta de gran relevancia tanto social como económica: no solo es una de las especies productoras de aceite más importantes del área mediterránea, sino que también tiene trascendencia en ... -
Exploración funcional y alergénica de los tejidos reproductivos del olivo (Olea europaea)
(2022)El olivo (Olea europaea) tiene una gran importancia socioeconómica debido a la producción de aceite y aceitunas de mesa. España es el primer productor mundial y, de las 272 variedades presentes en nuestro país, Picual es ... -
Genomic analysis of the marine fish pathogen Photobacterium damselae subsp. piscicida: Insertion sequences proliferation is associated with chromosomal reorganisations and rampant gene decay.
Balado, Miguel; Benzekri, Hicham; Labella Vera, Alejandro Manuel; Claros-Díaz, Manuel Gonzalo; Manchado, Manuel; Borrego-García, Juan José; Osorio, Carlos; Lemos, Manuel[et al.] (Elsevier, 2017)
Photobacterium damselae subsp. piscicida (Pdp) is an intracellular fish pathogen that causes photobacteriosis, a disease proven deadly in farmed fish worldwide. This work focuses on the analysis of genome sequences, ... -
Importancia de la bioinformática en la implementación de la medicina personalizada de precisión en los sistemas sanitarios: el caso del cáncer de pulmón
(UMA Editorial, 2023)Esta tesis doctoral aborda la medicina personalizada de precisión (MPP) en distintas fases de su desarrollo, desde la investigación hasta la implementación en la rutina clínica, y desde distintos enfoques. Este trabajo ... -
Insights into ROS‐dependent signalling underlying transcriptomic plant responses to the herbicide 2,4‐D
Romero Puertas, María C.; Peláez-Vico, María Ángeles; Pazmiño, Diana M.; Rodríguez Serrano, María; Terrón Camero, Laura; Bautista-Moreno, Rocío; Gómez-Cadenas, Aurelio; Claros-Díaz, Manuel Gonzalo; León, José; Sandalio, Luisa M.[et al.] (Plant Cell & Environment, 2022)
The synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D) functions as an agronomic weed control herbicide. High concentrations of 2,4-D induce plant growth defects, particularly leaf epinasty and stem curvature. Although ... -
Nitric oxide-dependent regulation of sweet pepper fruit ripening
Claros-Díaz, Manuel Gonzalo; González-Gordo, Salvador; Bautista-Moreno, Rocío; Cañas, Amanda; Palma, José M.; Corpas, Francisco J.[et al.] (Journal of Experimental Botany, 2019)
Ripening is a complex physiological process that involves changes in reactive nitrogen and oxygen species that govern the shelf-life and quality of fruits. Nitric oxide (NO)-dependent changes in the sweet pepper fruit ... -
OliveAtlas: a gene expression atlas tool for olea europaea
Bullones, Amanda; Castro, Antonio Jesús; Lima-Cabello, Elena; Alché, Juan de Dios; Luque, Francisco; Claros-Díaz, Manuel Gonzalo; Fernández-Pozo, Noé[et al.] (MDPI, 2023-03-10)
The olive (Olea europaea L.) is an ancient crop of great importance in the Mediterranean basin due to the production of olive oil and table olives, which are important sources of fat and have benefits for human health. ... -
Plataforma de supercomputación para bioinformática
(Servicio de Publicaciones y Divulgacion Científica, 2015)En el año 2007 la Universidad de Málaga amplió y trasladó sus recursos de cálculo a un nuevo centro dedicado exclusivamente a la investigación: el edificio de Supercomputación y Bioinnovación sito en el Parque Tecnológico ... -
Regulatory role of microRNA in mesenteric lymph nodes after Salmonella Typhimurium infection
Claros-Díaz, Manuel Gonzalo; Herrera‐Uribe, Juber; Zaldívar‐López, Sara; Aguilar, Carmen; Luque, Cristina; Bautista-Moreno, Rocío; Carvajal, Ana; Garrido, Juan José[et al.] (Veterinary Research, 2018)
Salmonellosis is a gastrointestinal disease caused by non‐typhoidal Salmonella serovars such as Salmonella Typhimu‐ rium. This pathology is a zoonosis, and food animals with subclinical infection constitute a vast reservoir ...