Listar por autor "Sanchez-Mico, María Virtudes"
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sánchez-Varo, Raquel María
; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gómez-Arboledas, Ángela; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Gutiérrez-Pérez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.
Sanchez-Mico, Maria Virtudes; Jiménez, Sebastián; Gómez-Arboledas, Ángela; Muñoz-Castro, Clara; Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Mejías, Elisabeth; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Galea, Elena; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Wiley, 2020-12-07)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ... -
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Fernández-Valenzuela, Juan José; Sanchez-Mico, Maria Virtudes; Muñoz-Castro, Clara; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Vizuete, Marisa[et al.] (Frontiers, 2018-11-14)
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ... -
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Baglietto-Vargas, David; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Gómez-Arboledas, Ángela; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Vizuete, Marisa; Dávila-Cansino, José Carlos; García-Verdugo, José Manuel; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2017)
Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gómez-Arboledas, Ángela; Davila, Jose Carlos; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Fernández-Valenzuela, Juan José; Vizuete, Marisa; Comella, Joan X.; Galea, Elena; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2018-03)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Mejías-Ortega, Marina; Gómez-Arboledas, Ángela; Jimenez, Sebastian; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; Baglietto-Vargas, David; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Frontiers, 2021-11-04)
Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ... -
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Springer Nature, 2016-10-14)
El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ...