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Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
Moreno-González, Inés; Edwards III, George; Salvadores, N.; Shahnawaz, Mohammad; Diaz-Espinoza, R.; Soto, C.[et al.] (Springer Nature, 2017)Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association ... -
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.
Diaz-Espinoza, R.; Morales, Rodrigo; Concha-Marambio, Luis; Moreno-González, Inés; Moda, Fabio; Soto, Claudio[et al.] (Springer Nature, 2018)Transmissible spongiform encephalopathies (TSEs) are fatal neurological disorders caused by prions, which are composed of a misfolded protein (PrP Sc) that self-propagates in the brain of infected individuals by converting ...