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Listar por autor "Moolenaar, Wouter H"
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Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
Matas-Rico, Elisa; Frijlink, Elselien; Morris, Andrew; Moolenaar, Wouter H; Koster, Jan; van der Haar, Irene; Menegakis, Apostolos; van Zon, Maaike; Salgado-Polo, Fernando; De Kivit, Sander; Johnson, Zoe; Haanen, John; Schumacher, Ton; Borst, Jannie; Verbrugge, Inge; van den Berg, Joost; Perrakis, Anastassis[et al.] (2022)To improve the efficacy of immunotherapy, it is essential to better understand how cytotoxic CD8+ T cells infiltrate into tumors. Here, we examine a role for autotaxin (ATX) in this process. ATX (encoded by ENPP2) is a ... -
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
Matas-Rico, Elisa; Moolenaar, Wouter H; Frijlink, Elselien; van der Haar Àvila, Irene; Menegakis, Apostolos; van Zon, Maaike; Morris, Andrew J; Koster, Jan; Salgado-Polo, Fernando; de Kivit, Sander; Lança, Telma; Mazzocca, Antonio; Johnson, Zoë; Haanen, John; Schumacher, Ton N; Perrakis, Anastassis; Verbrugge, Inge; van den Berg, Joost H; Borst, Jannie[et al.] (CELLPRESS, 2021)Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. ATX/LPA promotes tumor cell migration and metastasis via LPAR1 and ... -
GDE2/GDPD5 in neuroblastoma
Matas-Rico, Elisa; van Veen, Michiel; Moolenaar, Wouter H (Impact Journals, 2017-01)No abstract available -
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish
van Veen, Michiel; Mans, Laurie A; Matas-Rico, Elisa; van Pelt, Jason; Perrakis, Anastassis; Moolenaar, Wouter H; Haramis, Anna-Pavlina G[et al.] (Elsevier, 2018-01)Notch signaling plays an essential role in the proliferation, differentiation and cell fate determination of various tissues, including the developing pancreas. One regulator of the Notch pathway is GDE2 (or GDPD5), a ... -
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor
Jongsma, Maikel; Matas-Rico, Elisa; Jalink, Kees; Moolenaar, Wouter H; Rzadkowski, Adrian (PLOS One, 2011-12)Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA1–6, showing ... -
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
van Veen, Michiel; Matas-Rico, Elisa; van de Wetering, Koen; Leyton-Puig, Daniela; Kedziora, Katarzyna M; De Lorenzi, Valentina; Stijf-Bultsma, Yvette; van den Broek, Bram; Jalink, Kees; Sidenius, Nicolai; Perrakis, Anastassis; Moolenaar, Wouter H[et al.] (Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
Salgado-Polo, Fernando; van Veen, Michiel; van den Broek, Bram; Jalink, Kees; Leyton-Puig, Daniela; Perrakis, Anastassis; Moolenaar, Wouter H; Matas-Rico, Elisa[et al.] (The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ... -
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
Keune, Willen-Jan; Hausmann, Jens; Bolier, Ruth; Tolenaars, Dagmar; Kremer, Andreas; Heidebrecht, Tatjana; Joosten, Robbie P; Sunkara, Manjula; Morris, Andrew J; Matas-Rico, Elisa; Moolenaar, Wouter H; Oude Elferink, Ronald P; Perrakis, Anastassis[et al.] (Springer Nature, 2016-04)Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA). ATX-LPA signalling is involved in multiple biological and pathophysiological processes, including vasculogenesis, fibrosis, cholestatic pruritus and ... -
Tumor immune escape by autotaxin: keeping eosinophils at bay
Matas-Rico, Elisa; Moolenaar, Wouter H (Elsevier, 2024-04)Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al. show that ATX/LPA signaling ...