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Effects of cocoa-derived polyphenols treatment in regulating the adverse impacts of early-life stress in male and female mice.
Castro-Zavala, Adriana; Melgar-Locatelli, Sonia; Mañas-Padilla, María del Carmen; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela(2023)
Depression is one of the mental disorders that significantly affects today's society and calls for new treatments. In recent years, the gut microbiota has emerged as a key modulator of behaviour and mood due to the existence ... -
Estudio del cacao como potenciador de la neurogénesis y la función hipocampal en ratones adultos
Introducción: La formación de nuevas neuronas es un fenómeno neuroplástico esencial que se produce en el cerebro adulto, concretamente en el giro dentado del hipocampo (neurogénesis hipocampal adulta, NHA). Numerosos ... -
Exploring the nutritional composition and bioactive compounds in different cocoa powders
Razola-Díaz, María del Carmen; Aznar-Ramos, María José; Verardo, Vito; Melgar-Locatelli, Sonia; Castilla-Ortega, María Estela; Rodríguez-Pérez, Celia[et al.] (MDPI, 2023-03-14)
Cocoa, the main derivative of the seeds of Theobroma cacao L., has been recognized to have several effects on human health including antioxidant and neuro- and cardio-protective effects, among others. These effects have ... -
Impact of a cocoa-based diet rich in polyphenols on cognitive function, emotional behavior, and adult hippocampal neurogenesis in mice.
Melgar-Locatelli, Sonia; Mañas-Padilla, María del Carmen; Castro-Zavala, Adriana; Razola-Díaz, María del Carmen; Palma-Morales, Marta; Rivera-González, Patricia; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (2023)
Cocoa consumption has long been associated with numerous health benefits due to its rich composition of minerals, fiber, methylxanthines, and polyphenols, particularly flavanols. However, the cognitive effects of cocoa ... -
Reduction of adult neurogenesis by temozolomide inhibits intrinsic preference for exploring complex objects in mice
Melgar-Locatelli, Sonia; Mañas Padilla, María del Carmen; Gil-Rodríguez, Sara; Vicente, Lucía; Gálvez-Callejón, Ana Mar; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (2022)
Intrinsic exploratory bias is an innate tendency to prefer certain types of stimuli or environments over others. For example, mice would genuinely spent more time exploring perceptually complex objects (i.e. with edges and ... -
Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: a potential role of adult hippocampal neurogenesis in ‘curiosity’.
Mañas Padilla, María del Carmen; Melgar-Locatelli, Sonia; Vicente, Lucía; Gil-Rodríguez, Sara; Rivera, Patricia; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-12-14)
Intrinsic exploratory biases are an innate motivation for exploring certain types of stimuli or environments over others, and they may be associated with cognitive, emotional, and even personality-like traits. However, ...