Listar por autor "Borroto-Escuela, Dasiel"
Mostrando ítems 1-4 de 4
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Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
Borroto-Escuela, Dasiel; Serrano-Castro, Pedro Jesús
; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; Fuxe, Kjell; Narváez-Peláez, Manuel[et al.] (Taylor & Francis, 2024-04-21)
Background: Major Depressive Disorder (MDD) is a prevalent and debilitating condition, necessitating novel therapeutic strategies due to the limited efficacy and adverse effects of current treatments. We explored how galanin ... -
Intranasal Delivery of Galanin 2 and Neuropeptide Y1 Agonists Enhanced Spatial Memory Performance and Neuronal Precursor Cells Proliferation in the Dorsal Hippocampus in Rats.
Borroto-Escuela, Dasiel; Fores, Ramón; Pita-Rodríguez, Mariana; Barbancho-Fernández, Miguel Ángel; Zamorano-González, Pablo; García-Casares, Natalia; Fuxe, Kjell; Narváez-Peláez, Manuel[et al.] (Frontiers, 2022)
A need for new therapeutic approaches are necessary for dementia conditions and memory deficits of different origins, such as Alzheimer’s disease. There is complex pathophysiological mechanisms involved, affecting adult ... -
On the Role of Neuropeptide Y Receptor 1 (NPY1R)-Galanin Receptor 2 (GALR2) Heteroreceptor Complexes in Enhancing Adult Hippocampal Neurogenesis and Cognitive Function
(UMA Editorial, 2024-09)This PhD thesis investigates the roles of Neuropeptide Y receptor 1 (NPY1R) homo- and heteroreceptor complexes, specifically NPY1R- galanin receptor 2 (GALR2) heteroreceptor complexes, within the Central Nervous System ... -
Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus
(Taylor & Francis, 2024-04-18)Background: Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects ...