Listar por autor "Dávila-Cansino, José Carlos"
Mostrando ítems 1-20 de 25
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Abeta from APP/PS1 Alzheimer mice hippocampus induced synaptic damage in vivo and in vitro
Sanchez-Varo, Raquel; De Castro Carratalá, Vanessa; Trujillo-Estrada, Laura Isabel
; Sanchez-Mejias, Elisabet; Jimenez, Sebastian; Navarro, Victoria; Sanchez-Mico, Maria Virtudes; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Gutierrez-Perez, Antonia[et al.] (2017-10-02)
We aim to investigate the effects of Abeta from young APP/PS1 mouse model of Alzheimer`s disease (AD) on the synaptic integrity, as the loss of synapses strongly correlates with cognitive deficits in patients. Plaque-associated ... -
Analyzing hippocampal synaptic damage and glial response in a mouse model of tauopathy
Fernandez-Valenzuela, Juan José; Sánchez-Varo, Raquel; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2017-10-04)
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and dementia in Alzheimer’s disease (AD) and other tauopathies. Tau transgenic mice are widely used to investigate the specific ... -
Astroglial reactivity in response to b-amyloidosis is associated with mithocondrial pathology in the hippocampus of Alzheimer's transgenic mice
López Oliva, Elba; Trujillo-Estrada, Laura Isabel; Sanchez Mejias, Elisabeth; Mejias-Ortega, Marina; Fernandez-Valenzuela, Juan José; Gomez-Arboledas, Angela; Dávila-Cansino, José Carlos; Vitorica, Francisco Javier; Gutierrez-Perez, Antonia[et al.] (2023-04)
Aims: Alzheimer’s diseaase (A)D is associated with early energy hypometabolism, synaptic and mitochondrial dysfunction, oxidative stress, inflammation, abnormal proteostasis and progressive neurodegeneration. During the ... -
Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients
Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Dávila-Cansino, José Carlos; Gutierrez-Perez, Antonia; Vitorica, Javier (Wiley, 2021)
Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
Mejías-Ortega, Marina; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Trujillo-Estrada, Laura Isabel; Sanchez-Varo, Raquel; Dávila-Cansino, José Carlos; Dávila-Cansino, José Carlos; Gutierrez-Perez, Antonia[et al.] (2020-12-16)
Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Comparing astroglial reactivity in two transgenic mouse models of tauopathy
Fernandez Valenzuela, Juan José; Sanchez Varo, Raquel; López Oliva, Elba; Romero Molina, Carmen; Mejias Ortega, Marina; Sanchez-Mejias, Elisabet; Vizuete, Maria Luisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2021-11-03)
Astrocytes are becoming crucial players in the pathology of neurodegenerative disorders, such as Alzheimer’s disease (AD). Astrocyte responses have been mainly analyzed in the context of amyloid-beta (Abeta) pathology, ... -
Decoding damage-associated microglia in post mortem hippocampus of Alzheimer’s disease patients
Sanchez-Mejias, Elisabet; Mejias-Ortega, Marina; Navarro, Victoria; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Sanchez-Varo, Raquel; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-18)
The relationship between Alzheimer’s disease (AD) and neuroinflammation has become stronger since the identification of several genetic risk factors related to microglial function. Though the role of microglial cells in ... -
Disentangling the contribution of tau and abeta pathologies in transgenic models of Alzheimer's disease
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; Navarro, Victoria; Jimenez, Sebastian; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2018-07-20)
AIMS: Amyloid-beta (Abeta) deposits and intraneuronal hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). The coexistence of these aggregates in AD brains leads to synaptic dysfunction, ... -
Dissecting the microglial response in transgenic models of amyloidogenesis and tauopathy
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Romero-Molina, Carmen; Sanchez-Mejias, Elisabet; Gomez-Arboledas, Angela; Nuñez-Diaz, Cristina; Navarro, Victoria; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-19)
Amyloid-beta (Abeta) peptide deposits and hyperphosphorylated tau protein (phospho-tau) accumulate in Alzheimer’s disease (AD) brains. These abnormal protein aggregates leads to glial activation, synaptic dysfunction, ... -
Epothilone-d rescues cognition and attenuates alzheimer’s disease-like pathology in APP/PS1 mice
Ferbandez-Valenzuela, Juan Jose; Sanchez-Varo, Raquel; De Castro Carratalá, Vanessa; Moyano, Francisco; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2016-09-09)
AIMS: Cognitive decline in Alzheimer's disease (AD) patients has been linked to synaptic damage and neuronal loss. Hyperphosphorylation of tau protein destabilizes microtubules leading to the accumulation of autophagy/vesicular ... -
Fast and efficient generation of oligodendrocytes from human induced pluripotent stem cells (hiPSCs)
Garcia-Leon, Juan Antonio; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica, Javier; Verfaillie, Catherine; Gutierrez-Perez, Antonia[et al.] (Wiley, 2021-07)
Oligodendrocytes (OLs) are highly specialized cells of the central nervous system responsible for myelin production and metabolic support of neurons. Defects in OLs are crucial in several neurodegenerative diseases including ... -
Human pluripotent stem cell-derived astrocytes from alzheimer´s disease patients for disease modeling
Cáceres Palomo, Laura; López Oliva, Elba; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia; Garcia-Leon, Juan Antonio[et al.] (2022)
Aims: The lack of reliable models of Alzheimer´s disease (AD) has impeded the development of effective therapies. Glial cells have a key role in AD pathology, but this cannot be properly modeled using available animal ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
Garcia-Leon, Juan Antonio; Cáceres Palomo, Laura; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia (2020-12-18)
Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
In vitro modeling of dysfunctional glial cells in neurodegenerative diseases using human pluripotent stem cells
Garcia-Leon, Juan Antonio; Eggermont, K; Neyrinck, K; Dávila-Cansino, José Carlos; Vitorica, Javier; Verfaillie, C; Gutierrez-Perez, Antonia[et al.] (2019-07-26)
Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable models, have precluded the development of effective therapies counteracting ... -
LITIO COMO TERAPIA NEUROPROTECTORA EN EL MODELO APPSL/PS1M146L DE LA ENFERMEDAD DE ALZHEIMER
Trujillo-Estrada, Laura Isabel; Baglietto-Vargas, David; Moreno González, Inés; De Castro Carratalá, Vanessa; Jimenez, Sebastian; Sanchez-Varo, R; Sanchez-Mejias, Elisabet; Vizuete, M; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2013)
El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). ... -
Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Jimenez, Sebastian; Sanchez-Varo, Raquel; Muñoz-Castro, Clara; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2018-07-20)
Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microglial responses in the human Alzheimer’s disease frontal cortex
Mejias-Ortega, Marina; Sanchez-Mejias, Elisabet; Navarro, Victoria; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Sanchez-Varo, Raquel; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2019-07-17)
The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
Sanchez-Varo, Raquel; Fernandez-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Sanchez-Mejias, Elisabet; Nuñez-Diaz, Cristina; Gómez-Arboledas, Ángela; Moreno González, Inés; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (2020-12-17)
Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sanchez-Varo, Raquel; Fernandez Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sanchez-Mejias, Elisabet; Navarro, V; Jimenez, Sebastian; Nuñez-Diaz, Cristina; Gomez-Arboledas, Angela; Moreno-Gonzalez, Ines; Moyano, F; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutierrez-Perez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Patología glial en el hipocampo de modelos transgénicos de la enfermedad de Alzheimer: un enfoque ultraestructural
(UMA Editorial, 2018)La enfermedad de Alzheimer, principal causa de demencia entre las personas mayores de 65 años, genera un grave impacto socio sanitario y hasta la fecha no existe ninguna terapia eficaz. La hipótesis de la cascada amiloide ...