Listar por autor "Fuxe, Kjell"
Mostrando ítems 1-20 de 49
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A Role For Galanin N-Terminal Fragment (1-15) In Anxiety And Depression in rats
Millon-Peñuela, Carmelo
; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; Narváez, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
Galanin (GAL) is involved in several functions including mood regulation. The GAL N-terminal fragment (1-15) [GAL(1-15)] also participates at central level and a differential role of GAL(1-15) compared with GAL has been ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez, Manuel; Borroto-Escuela, Dasiel; Millon-Peñuela, Carmelo; Gago-Calderon, Belen; Flores-Burgess, Antonio; Santin-Nuñez, Luis Javier; Fuxe, Kjell; Narváez, José Ángel; Díaz-Cabiale, Zaida[et al.] (2017-08-30)
Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramirez, Alicia; Suárez-Boomgaard, Diana; Gago-Calderon, Belen; Valderrama-Carvajal, Alejandra; Medina-Luque, José; Roales-Buján, Ruth; Fuxe, Kjell; De-la-Calle-Martin, Adelaida[et al.] (2013)
Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; Garcia-Duran, Laura; Gago-Calderon, Belen; Flores-Burgess, Antonio; Alén, Francisco; Orio, Laura; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida; Millon-Peñuela, Carmelo; Garcia-Duran, Laura[et al.] (2019-09-10)
Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderon, Belen; Garcia-Duran, Laura; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2019-11-18)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
Garcia-Duran, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderon, Belen; Allén, Francisco; Orio, Laura; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida; Millon-Peñuela, Carmelo[et al.] (2019-09-12)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
Garcia-Cantero, Noelia; Flores-Burgess, Antonio; Gago-Calderon, Belen; Garcia-Duran, Laura; Alén, Francisco; Orio, Laura; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida; Millon-Peñuela, Carmelo[et al.] (2021-01-22)
The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
GAL(1-15) induces a depression and anxiogenic effect trough GALR1/GALR2 heteroreceptor: siRNA GALR1/GALR2 knockdown rats
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; Parrado-Romero, Concepcion; Narváez, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
Galanin (1-15) and escitalopram combination in rats reduces alcohol consumption in the ethanol self-administration test and improves escitalopram effects in the forced swimming test.
Cantero García, Noelia; Flores-Burgess, Antonio; Ladrón de Guevara-Miranda, David; Serrano, Antonia; Garcia-Duran, Laura; Puigcerver-Martinez, Araceli; Fuxe, Kjell; Narváez, José Ángel; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida; Millon-Peñuela, Carmelo[et al.] (2022-07-12)
Recently, we described that Galanin(1-15)[GAL(1-15)] enhanced Escitalopram(ESC) effectiveness in depression symptoms. Moreover GAL(1-15) induces a substantial reduction in alcohol consumption. To investigate the effect of ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millon-Peñuela, Carmelo; Puigcerver-Martinez, Araceli; Gago-Calderon, Belen; Garcia-Duran, Laura; Cantero-García, Noelia; Narváez, José Ángel; Santin-Nuñez, Luis Javier; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2019-06-17)
Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ... -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millon-Peñuela, Carmelo; Gago-Calderon, Belen; Narváez, Manuel; Borroto-Escuela, Dasiel O.; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2017)
The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ... -
Galanin (1-15) potentiates the antidepres-sant-like effects induced by Escitalopram in a rat model of depression
Garcia-Duran, Laura; Flores-Burgess, Antonio; Cantero-García, Noelia; Puigcerver-Martinez, Araceli; Narváez, José Ángel; Fuxe, Kjell; Santin-Nuñez, Luis Javier; Millon-Peñuela, Carmelo; Díaz-Cabiale, Zaida[et al.] (2021-10-07)
Selective 5-HT reuptake inhibitor antidepressants (SSRIs) are the first choice in major depressive disorder (MDD), but 50% of affected patients do not show improvement. Galanin(1-15) [GAL(1-15)] enhanced Fluoxetine ... -
Galanin and galanin fragment 1-15 modulate antidepressant responses by targeting 5-HT1AR-GALR heteroreceptor complexes of the ascending midbrain serotonin pathways.
Millon-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santin-Nuñez, Luis Javier; Narváez, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (Cinp, 2016-07-03)
Mood disorders, including depression and anxiety, are among the most prevalent mental illnesses with high socioeconomic impact. Although the underlying mechanisms have not yet been clearly defined in the last decade the ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory
Mirchandani-Duque, Marina; Barbancho-Fernandez, Miguel Angel; López-Salas, Alexander; Alvarez-Contino, Jose Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; Narváez, Manuel[et al.] (IOAP-MPDI, 2022-06-01)
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory
Mirchandani-Duque, Marina; Barbancho-Fernandez, Miguel Angel; López-Salas, Alexander; Alvarez-Contino, Jose Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel; Narváez, Manuel[et al.] (2022-09-22)
Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses ... -
Galanin and Neuropeptide Y interaction leads to antidepressant effects through hippocampal cell proliferation.
Narváez, Manuel; Fores-Pons, Ramón; Pita-Rodríguez, Mariana; Fuxe, Kjell; Borroto-Escuela, Dasiel (2020-09-01)
Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ...