Listar por autor "Díaz-Morilla, Amelia"
Mostrando ítems 1-20 de 21
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Adsorbatos isoquinolínicos y benzazepínicos: síntesis e incorporación a superficies de silicio y nanopartículas
(UMA Editorial, 2019)La mayoría de los productos farmacéuticos aprobados por la FDA presentan en su estructura átomos de nitrógeno. De hecho, más de la mitad de ellos incluyen un heterociclo de nitrógeno. Entre los heterociclos de nitrógeno ... -
Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernández, María
; Lucena-Serrano, Cristina; Rivera-Ramírez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
Fuentes-Ríos, David; Muñoz, Carmen; Díaz-Morilla, Amelia; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel (Royal Society of Chemistry, 2023-03-13)
The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Diastereoselective synthesis of chiral amines by imines alkylation
Díaz-Morilla, Amelia; Muñoz, Carmen; Sánchez, María; Valpuesta-Fernández, María (2013-10-03)
En esta comunicación se aborda la síntesis de aminas quirales utilizando como agente alquilante trietilborano. -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
Contreras-Cáceres, Rafael; Cabeza, Laura; Perazzoli, Gloria; Díaz-Morilla, Amelia; López-Romero, Juan Manuel; Melguizo, Consolación; Prados, Jose[et al.] (MDPI, 2019-04)
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery
García-Pinel, Beatriz; Ortega Rodríguez, Alicia; Porras Alcalá, Cristina; Cabeza, Laura; Contreras-Cáceres, Rafael; Ortiz, Raúl; Díaz-Morilla, Amelia; Moscoso, Ana; Sarabia-García, Francisco Ramón; Prados, Jose; López-Romero, Juan Manuel; Melguizo, Consolación[et al.] (Taylor and Francis, 2020-04-19)
Here, temperature-sensitive hybrid poly(N-isopropylacrylamide) (pNIPAM) nanosystems with magnetic response are synthesised and investigated for controlled release of 5-fluorouracil (5FU) and oxaliplatin (OXA). Initially, ... -
n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine
García-Castro, Miguel; Fuentes-Ríos, David; López-Romero, Juan Manuel; Romero, Antonio; Moya-Utrera, Federico; Díaz-Morilla, Amelia; Sarabia-García, Francisco Ramón[et al.] (MDPI, 2023-12-13)
A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic ... -
Nanoscale biocompatible structures generated from fluorinated tripodal phenylenes on gold nanoprisms
García-Castro, Miguel; Moscoso, Ana; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel; Contreras-Cáceres, Rafael; Díaz-Morilla, Amelia[et al.] (Wiley, 2022-03-09)
Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio-devices. We present the fabrication of hybrid systems consisting ... -
Síntesis de tetrahidroisoquinolinas y tetrahidro-3-benzazepinas. Evaluación de su actividad dopaminérgica.
(Publicaciones y Divulgación Científica. Universidad de Málaga, 2020)Las tetrahidro-3-benzazepinas (THBs) son una clase de compuestos heterocíclicos que se caracterizan por la presencia en su estructura de un anillo bencénico condensado con un anillo de azepina. La importancia de estos ... -
SPION Nanoparticles for Delivery of Dopaminergic Isoquinoline and Benzazepine Derivatives.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; Villaverde, Gonzalo; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón; Laurenti, Marco; Rubio Retama, Jorge; Contreras-Cáceres, Rafael[et al.] (Elsevier, 2022-06-27)
Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with ... -
Study and characterization of modified silicon surfaces with organic molecules
Valpuesta-Fernández, María; Sánchez-Molina, María; Lucena-Serrano, Ana; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows ... -
Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Rivera-Ramírez, Alicia; López-Romero, Juan Manuel; Valpuesta-Fernández, María; Díaz-Morilla, Amelia[et al.] (Elsevier, 2018-07-05)
A series of new 1-aryl-6,7-dihydroxy tetrahydroisoquinolines with several substitution patterns in the 1-aryl group at C-1 were prepared in good yields. The influence of each substituent on the affinity and selectivity for ... -
Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines
Lucena-Serrano, Ana; Lucena-Serrano, Cristina; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ... -
Synthesis of (-)-cannabidiol (CBD),(-)-Δ9- and(-)--Δ8-tetrahydrocannabinols, encapsulation of CBD with nanoparticles for controlled delivery and biological evaluation
Moya-Utrera, Federico; Fuentes-Ríos, David; Romero-Carrasco, Antonio; Doña Flores, Manuel; Cheng-Sánchez, Iván; Díaz-Morilla, Amelia; Pino-González, María Soledad; Martínez-Férez, Antonio; Moreno, Javier; Mesas, Cristina; Melguizo, Consolación; Prados, José; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel[et al.] (Wiley, 2024-12)
Cannabidiol (CBD) is garnering increasing interest due to its significant biological activity. This natural compound is one of the major cannabinoids in Cannabis sativa L. In this work, we describe the encapsulation of CBD ... -
Synthesis of bioactive compounds. Studies of their attachment to nanoparticles
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ... -
The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria
Porras Alcalá, Cristina; Moya-Utrera, Federico; García-Castro, Miguel; Sánchez-Ruiz, Antonio; López-Romero, Juan Manuel; Pino-González, María Soledad; Díaz-Morilla, Amelia; Kitamura, Seiya; W. Wolan, Dennis; Prados, Jose; Melguizo, Consolación; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón[et al.] (IOAP-MPDI, 2022-05-31)
The bengamides comprise an interesting family of natural products isolated from sponges belonging to the prolific Jaspidae family. Their outstanding antitumor properties, coupled with their unique mechanism of action and ... -
Transformaciones, reactividad y síntesis de protopinas
Díaz-Morilla, Amelia (Universidad de Málaga, Servicio de Publicaciones, 2003)
Esta tesis se enmarca dentro del campo de los alcaloides isoquinolínicos. La búsqueda de nuevas estructuras, el estudio de reactividad y sintesis, su posible actividad biológica y otros aspectos relacionados con su ... -
Tripod-shaped molecules: Synthesis and immobilization on Au(1 1 1) substrates.
Sánchez-Molina, María; Díaz-Morilla, Amelia; Sauter, Eric; Zharnikov, Michael; López-Romero, Juan Manuel (2018-11-09)
We describe design and synthesis of novel tripod-shaped molecules that are potentially capable of monomolecular assembly on noble metal substrates, maintaining, due to their rigidity and specific geometry, the orientation ... -
Tripod-shaped penta (p-phenylene)s for the functionalization of silicon surfaces
Sánchez-Molina, María; Contreras-Cáceres, Rafael; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; López-Romero, Juan Manuel (2016-03-31)
In order to obtain nanostructured thin films to be used in biosensor devices, several chemical functionalization methods have been developed, such as Click chemistry or Suzuki carbon-carbon coupling reactions on surfaces.1 ... -
Tripodal p-phenylene Molecules: Synthesis and Immobilization on Gold and Silicon Substrates
(Uma Editorial, 2019-10)La principal hipótesis de este trabajo de Tesis consiste en que la máxima efectividad de cualquier dispositivo se logrará con la estructuración a nivel molecular de las superficies. Por ello es necesario disponer de métodos ...