Listar por autor "Mañas Padilla, María del Carmen"
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Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero Zerbo, Silvana Yanina
; García-Fernández, Maria Inmaculada; Santin-Nuñez, Luis Javier[et al.] (2022-07)
Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2021)
Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, ... -
Deterioro cognitivo inducido por cocaína: una revisión sistemática
(2020-12-15)La adicción a las drogas es un trastorno crónico y recurrente caracterizado por la búsqueda compulsiva de la droga, y la disminución de la capacidad para limitar la ingesta. En la adicción a la cocaína, las áreas del cerebro ... -
Educación superior y emociones, bases epistemológicas de Maturana
Mañas Padilla, María del Carmen; Edelkraut, Lisa; Castilla-Ortega, María Estela; Araos, Pedro (2021-11-20)
Introducción. Las emociones serán entendidas como las disposiciones corporales que especifican el dominio de acción en que ese mueve el organismo. Son el fundamento de muchos aspectos de la vida y la educación es parte de ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santin-Nuñez, Luis Javier[et al.] (2019-07-03)
Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santin-Nuñez, Luis Javier[et al.] (2019-10-01)
Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice
Mañas Padilla, María del Carmen; Tezanos, Patricia; Cintado, Elisa; Vicente, Lucía; Sánchez-Salido, Lourdes; Gil-Rodriguez, Sara; Trejo-Pérez, José Luis; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-11-16)
Cocaine is a widely used psychostimulant drug whose repeated exposure induces persistent cognitive/emotional dysregulation, which could be a predictor of relapse in users. However, there is scarce evidence on effective ... -
Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference
Mullor-Vigo, Rosa; Ávila-Gámiz, Fabiola; Zambrana-Infantes, Emma; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Santin-Nuñez, Luis Javier; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis Javier[et al.] (2022)
AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning ... -
Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine
Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil-Rodriguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2021)
Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely ... -
Persistent drug-associated memories coexist with hippocampal-dependent cognitive decline and altered adult hippocampal neurogenesis in mice withdrawn from cocaine.
Mañas Padilla, María del Carmen; Gil-Rodriguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2019-10-01)
Aims: Using a new animal model (‘chronic’ cocaine-induced conditioned place preference –CPP- paradigm), this work studied whether the long-term maintenance of cocaine-associated memories was concomitant to cognitive ... -
¿Podemos realizar una actividad de discusión grupal en un entorno virtual?
Edelkraut, Lisa; Mañas Padilla, María del Carmen; Araos, Pedro; Pedraza-Benítez, Maria del Carmen; Castilla-Ortega, María Estela (2021-11-20)
Introducción. La adaptación de la docencia universitaria a los entornos virtuales, debido a la pandemia de la COVID-19, puede resultar más compleja en el caso de actividades que requieren una interacción dinámica entre ... -
Reduction of adult neurogenesis by temozolomide inhibits intrinsic preference for exploring complex objects in mice
Melgar-Locatelli, Sonia; Mañas Padilla, María del Carmen; Gil-Rodriguez, Sara; Vicente, Lucía; Gálvez-Callejón, Ana Mar; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (2022)
Intrinsic exploratory bias is an innate tendency to prefer certain types of stimuli or environments over others. For example, mice would genuinely spent more time exploring perceptually complex objects (i.e. with edges and ... -
Remote memory of drug experiences coexists with cognitive decline and abnormal adult neurogenesis in an animal model of cocaine-altered cognition
Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Sampedro-Piquero, Patricia; Ávila-Gámiz, Fabiola; Rodriguez-de-Fonseca, Fernando; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2021)
Cocaine addiction is a chronic disorder in which the person loses control over drug use. The past memories of the stimuli associated with the drug are a relevant clinical problem, since they trigger compulsive drug seeking ... -
Spatial training in the Water Maze facilitates extinction and prevents reinstatement of cocaine-induced Conditioned Place Preference
Ávila-Gámiz, Fabiola; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Zambrana-Infantes, Emma; Santin-Nuñez, Luis Javier; Ladrón de Guevara-Miranda, David[et al.] (2021)
Manipulation of adult hippocampal neurogenesis has been shown to affect the establishment of cocaine-context associations as well as extinction learning and reinstatement of these maladaptive memories. In this work, we ... -
Temozolomide treatment inhibits spontaneous motivation for exploring a complex object in mice: a potential role of adult hippocampal neurogenesis in ‘curiosity’.
Mañas Padilla, María del Carmen; Melgar-Locatelli, Sonia; Vicente, Lucía; Gil-Rodriguez, Sara; Rivera, Patricia; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-12-14)
Intrinsic exploratory biases are an innate motivation for exploring certain types of stimuli or environments over others, and they may be associated with cognitive, emotional, and even personality-like traits. However, ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis
Sampedro-Piquero, Patricia; Moreno-Fernández, Román D.; Mañas Padilla, María del Carmen; Gil Rodríguez, Sara; Gavito, Ana; Pavón, Francisco Javier; Pedraza-Benítez, Maria del Carmen; García-Fernández, Maria Inmaculada; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2018)
(AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the water maze paradigm, in which stress is a confounding factor that affects the AHN ... -
Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis.
Sampedro-Piquero, Patricia; Ladrón de Guevara-Miranda, David; Mañas Padilla, María del Carmen; Gil-Rodriguez, Sara; Gavito, Ana; Cano-Pavón, José Manuel; Pedraza-Benítez, Maria del Carmen; García-Fernández, María; Ladrón de Guevara-Miranda, David; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2018-07-20)
Learning experiences are potent modulators of adult hippocampal neurogenesis (AHN). However, the vast majority of findings on the learning-induced regulation of AHN derive from aversively-motivated tasks, mainly the ... -
Valoración de la docencia virtual por el profesorado universitario durante la pandemia de la COVID-19
(DYKINSON, S.L., 2021)La actual situación sanitaria propiciada por la COVID-19 ha forzado un cambio en el método habitual de llevar a cabo la docencia en al ámbito universitario, pasando de impartir las clases de un formato presencial a un ... -
Variables asociadas al Duelo Complicado tras una muerte traumática: Una revisión sistemática
(2017-04-05)El duelo es una experiencia humana universal, única y dolorosa que puede delimitarse en el tiempo, presenta una evolución previsiblemente favorable y requiere la necesidad de adaptación a la nueva situación. No obstante, ... -
Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test
Sampedro-Piquero, Patricia; Mañas Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Santin-Nuñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Springer, 2019)
The classic hole-board paradigm (a square arena with 16 holes arranged equidistantly in a 4x4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed ...