Listar por autor "Mañas-Padilla, María del Carmen"
Mostrando ítems 1-20 de 35
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A behavioral test battery only reveals Sex-Specific Differences in Spatial Reference Memory Acquisition in C57BL/6JRj Mice
Melgar-Locatelli, Sonia; Mañas-Padilla, María del Carmen; Gavito, Ana Luisa; Rivera-González, Patricia; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela
; Castro-Zavala, Adriana[et al.] (2024-01-15)
Sex disparities in declarative and spatial memory exist in humans, favoring either gender depending on the task. This trend is observed in rats but less so in mice. In our study with C57BL/6JRj mice, we conducted various ... -
A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer’s Disease
Esteban-Martos, Alvaro; Brokate-Llanos, Ana María; Real-Navarrete, Luis Miguel; Melgar-Locatelli, Sonia; De Rojas, Itziar; Castro-Zavala, Adriana; Bravo-Romero, María José; Mañas-Padilla, María del Carmen; García-González, Pablo; Ruiz-Galdón, Maximiliano; Pacheco-Sánchez, Beatriz; Polvillo, Rocío; Rodriguez-de-Fonseca, Fernando; González, Irene; Castilla-Ortega, María Estela; Muñoz-Gómez, Manuel; Rivera, Patricia; Reyes-Engel, Armando; Ruiz, Agustín; Royo-Sánchez-Palencia, José Luis[et al.] (MDPI, 2023)
Genome-wide association studies (GWAS) constitute a powerful tool to identify the different biochemical pathways associated with disease. This knowledge can be used to prioritize drugs targeting these routes, paving the ... -
Alteraciones conductuales y cognitivas inducidas por cocaína: beneficios del enriquecimiento ambiental.
(UMA Editorial, 2024)La cocaína es la droga sustancia ilegal más consumida después del cannabis. Su consumo acarrea numerosas consecuencias socioeconómicas y sanitarias y los consumidores de cocaína tienen un alto riesgo de desarrollar un ... -
Chronic cocaine exposure during adolescence in mice induces alterations in hippocampal neurogenesis and spatial memory
Gil Rodríguez, Sara; Mañas-Padilla, María del Carmen; Berdugo-Gómez, Mario; Ávila-Gámiz, Fabiola; Romero-Zerbo, Silvana Yanina; García-Fernández, María Inmaculada; Santín-Núñez, Luis Javier[et al.] (2022-07)
Objectives: Cocaine is the second most widely consumed illicit drug even at early ages, with a prevalence of 2.9% in Spain in the 14-18 age group. Chronic consumption produces several cognitive-behavioral and hippocampal ... -
Cognitive impairment and persistent changes in exploration and hyperactivity in mice after withdrawn from chronic cocaine
Mañas-Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (2021)
Lasting neurobehavioral adaptations such as cognitive decline are induced by chronic cocaine exposure in animal models. However, persistent changes in motor and exploratory responses are rarely reported. In this study, ... -
Deterioro cognitivo inducido por cocaína: una revisión sistemática
(2020-12-15)La adicción a las drogas es un trastorno crónico y recurrente caracterizado por la búsqueda compulsiva de la droga, y la disminución de la capacidad para limitar la ingesta. En la adicción a la cocaína, las áreas del cerebro ... -
Diet enriched with high-phenolic cocoa potentiates hippocampal brain-derived neurotrophic factor expression and neurogenesis in healthy adult micewith subtle effects on memory
Melgar-Locatelli, Sonia; Mañas-Padilla, María del Carmen; Castro-Zavala, Adriana; Rivera, Patricia; Razola-Díaz, María del Carmen; Monje, Francisco J; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela; Razola-Díaz[et al.] (Royal Society of Chemistry, 2024-08-12)
Cocoa is widely known for its health benefits, but its neurocognitive impact remains underexplored. This preclinical study aimed to investigate the effects of cocoa and cocoa polyphenols on hippocampal neuroplasticity, ... -
Educación superior y emociones, bases epistemológicas de Maturana
Mañas-Padilla, María del Carmen; Edelkraut, Lisa; Castilla-Ortega, María Estela; Araos Gómez, Pedro Fernando (2021-11-20)
Introducción. Las emociones serán entendidas como las disposiciones corporales que especifican el dominio de acción en que ese mueve el organismo. Son el fundamento de muchos aspectos de la vida y la educación es parte de ... -
Effect of a spatial memory training on the persistence of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas-Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier[et al.] (2019-07-03)
Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators ... -
Effects of cocoa-derived polyphenols treatment in regulating the adverse impacts of early-life stress in male and female mice.
Castro-Zavala, Adriana; Melgar-Locatelli, Sonia; Mañas-Padilla, María del Carmen; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela (2023)
Depression is one of the mental disorders that significantly affects today's society and calls for new treatments. In recent years, the gut microbiota has emerged as a key modulator of behaviour and mood due to the existence ... -
Enhancement of adult hippocampal neurogenesis by spatial memory training and its effect on the maintenance of cocaine-contextual memory
Ávila-Gámiz, Fabiola; Mañas-Padilla, María del Carmen; Ladrón de Guevara-Miranda, David; Gil Rodríguez, Sara; Rodriguez-de-Fonseca, Fernando; Castilla-Ortega, María Estela; Santín-Núñez, Luis Javier[et al.] (2019-10-01)
Aims:Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been asserted that learning-related experiences promote hippocampal ... -
Environmental enrichment alleviates cognitive and psychomotor alterations and increases adult hippocampal neurogenesis in cocaine withdrawn mice
Mañas-Padilla, María del Carmen; Tezanos, Patricia; Cintado, Elisa; Vicente, Lucía; Sánchez-Salido, Lourdes; Gil-Rodríguez, Sara; Trejo-Pérez, José Luis; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Wiley, 2022-11-16)
Cocaine is a widely used psychostimulant drug whose repeated exposure induces persistent cognitive/emotional dysregulation, which could be a predictor of relapse in users. However, there is scarce evidence on effective ... -
Evaluación neuropsicológica en daño cerebral adquirido: propuesta de aprendizaje basado en proyectos para estudiantes del máster en psicología general sanitaria.
Serrano-Ibáñez, Elena Rocío; Ortega-Acosta, Sergio; Mañas-Padilla, María del Carmen; Castro-Zavala, Adriana; Rodríguez-Martínez, María del Carmen; Castilla-Ortega, María Estela[et al.] (2023)
Se relata la experiencia docente del proyecto “Neuropsicoartes (Npsicoartes): mejorando la calidad de vida e integración social de las personas con daño cerebral adquirido”, financiado por la Universidad de Málaga en el ... -
Experiencia de uso de un cómic (“Arrugas”) como material didáctico en el aula universitaria.
García Borrego, Raúl; Requena-Ocaña, Nerea; Mañas-Padilla, María del Carmen; Castro Zavala, Adriana; Araos Gómez, Pedro Fernando; Gil-Rodríguez, Sara; Caramés-Tejedor, José María; Ortega-Acosta, Sergio; Edelkraut, Lisa; Rivas-Herencia, Eugenio; Castilla-Ortega, María Estela[et al.] (2023)
En la actualidad, existen pocas experiencias docentes que incorporen el cómic al entorno universitario. En este trabajo hemos explorado la utilidad de un cómic (“Arrugas”, de Paco Roca) para mejorar el proceso de ... -
Impact of a cocoa-based diet rich in polyphenols on cognitive function, emotional behavior, and adult hippocampal neurogenesis in mice.
Melgar-Locatelli, Sonia; Mañas-Padilla, María del Carmen; Castro-Zavala, Adriana; Razola-Díaz, María del Carmen; Palma-Morales, Marta; Rivera-González, Patricia; Rodríguez-Pérez, Celia; Castilla-Ortega, María Estela[et al.] (2023)
Cocoa consumption has long been associated with numerous health benefits due to its rich composition of minerals, fiber, methylxanthines, and polyphenols, particularly flavanols. However, the cognitive effects of cocoa ... -
Influence of neurogenic improvement strategies on extinction and reinstatement of cocaine-induced conditioned place preference
Mullor-Vigo, Rosa; Ávila-Gámiz, Fabiola; Zambrana-Infantes, Emma; Mañas-Padilla, María del Carmen; Gil Rodríguez, Sara; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David; Santín-Núñez, Luis Javier[et al.] (2022)
AIMS: Modulation of adult hippocampal neurogenesis (AHN) has been shown to influence the maintenance of drug-context associations. We aimed to study whether the enhancement of AHN by using a water maze spatial learning ... -
Intervenciones basadas en el Arte en Daño Cerebral Adquirido: Experiencia de Aprendizaje Basado en Proyectos con estudiantes de Terapia Ocupacional.
Rodríguez-Martínez, María del Carmen; Serrano-Ibáñez, Elena Rocío; Ortega-Acosta, Sergio; Mañas-Padilla, María del Carmen; Castro-Zabala, Adriana; Castilla-Ortega, María Estela[et al.] (2023)
Introducción: El Aprendizaje Basado en Proyectos (ABP) es una metodología activa que se fundamenta en el constructivismo, siendo el alumnado el centro de su propio aprendizaje. Se ha demostrado que este método tiene un ... -
miRNA-132/212 Deficiency Disrupts Selective Corticosterone Modulation of Dorsal vs. Ventral Hippocampal Metaplasticity
Kouhnavardi, Shima; Cabatic, Maureen; Mañas-Padilla, María del Carmen; Malabanan, Marife-Astrid; Smani, Tarik; Cicvaric, Ana; Muñoz Aranzalez, Edison Alejandro; Koenig, Xavier; Urban, Ernst; Lubec, Gert; Castilla-Ortega, María Estela; Monje, Francisco[et al.] (2023)
Cortisol is a potent human steroid hormone that plays key roles in the central nervous system, influencing processes such as brain neuronal synaptic plasticity and regulating the expression of emotional and behavioral ... -
Nutrition and adult neurogenesis in the hippocampus: Does what you eat help you remember?
(2023-02-23)Neurogenesis is a complex process by which neural progenitor cells (NPCs)/neural stem cells (NSCs) proliferate and differentiate into new neurons and other brain cells. In adulthood, the hippocampus is one of the areas ... -
Persistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocaine
Mañas-Padilla, María del Carmen; Ávila-Gámiz, Fabiola; Gil-Rodríguez, Sara; Ladrón de Guevara-Miranda, David; Rodriguez-de-Fonseca, Fernando; Santín-Núñez, Luis Javier; Castilla-Ortega, María Estela[et al.] (Elsevier, 2021)
Repeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely ...