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Impaired Peripheral Lymphatic Function and Cerebrospinal Fluid Outflow in a Mouse Model of Alzheimer's Disease
Kwon, Wu; Moreno-Gonzalez, Ines; Taylor-Presse, Kaithlyn; Edwards, George; Gamez, Nazaret; Calderon, Olivia; Zhu, Be; Velasquez, Francisco C; Soto, Claudio; Sevick-Muraca, Eva Marie; Taylor-Presse[et al.] (Sage Journals, 2019)Cerebrospinal fluid (CSF) outflow from the brain occurs through absorption into the arachnoid villi and, more predominantly, through meningeal and olfactory lymphatics that ultimately drain into the peripheral lymphatics. ... -
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
Mukherjee, Abhisek; Morales-Scheihing, Diego; Salvadores, Natalia; Moreno-Gonzalez, Ines; Gonzalez, Cesar; Taylor-Presse, Kaithlyn; Mendez, Nicolas; Shahnawaz, Mohamed; Gaber, Ahmed Osama; Sabek, Omaima; Fraga, Daniel W; Soto, Claudio[et al.] (Rockefeller University PRess, 2017)Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP ... -
Peripheral delivery of neural precursor cells ameliorates parkinson’s disease-associated pathology
Edwards, George; Gámez, Nazaret; Armijo, Enrique; Kramm, Carlos; Morales, Rodrigo; Taylor-Presse, Kaithlyn; Schulz, Paul; Soto, Claudio; Moreno-González, Inés[et al.] (MDPI, 2019)Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute ...