• A New Multi-Objective Approach for Molecular Docking Based on RMSD and Binding Energy 

      López-Camacho, Esteban; García Godoy, María Jesús; García-Nieto, José; Nebro-Urbaneja, Antonio Jesus; Aldana-Montes, Jose Francisco (2016-07-12)
      Ligand-protein docking is an optimization problem based on predicting the position of a ligand with the lowest binding energy in the active site of the receptor. Molecular docking problems are traditionally tackled with ...
    • A Study of Archiving Strategies in Multi-Objective PSO for Molecular Docking 

      García-Nieto, José; López-Camacho, Esteban; García Godoy, María Jesús; Nebro-Urbaneja, Antonio Jesus; Durillo, Juan J.; [et al.] (2016-09-30)
      Molecular docking is a complex optimization problem aimed at predicting the position of a ligand molecule in the active site of a receptor with the lowest binding energy. This problem can be formulated as a bi-objective ...
    • About Designing an Observer Pattern-Based Architecture for a Multi-objective Metaheuristic Optimization Framework 

      Benítez-Hidalgo, Antonio; Nebro-Urbaneja, Antonio Jesus; Durillo, Juan J.; García-Nieto, José; López-Camacho, Esteban; [et al.] (2018-11-05)
      Multi-objective optimization with metaheuristics is an active and popular research field which is supported by the availability of software frameworks providing algorithms, benchmark problems, quality indicators and other ...
    • Bioqueries: a collaborative environment to create, explore and share SPARQL queries in Life Sciences 

      García-Godoy, Maria Jesús; López-Camacho, Esteban; Navas-Delgado, Ismael; Aldana-Montes, Jose Francisco (2016)
      Bioqueries provides a collaborative environment to create, explore, execute, clone and share SPARQL queries (including Federated Queries). Federated SPARQL queries can retrieve information from more than one data source.
    • Bioqueries: a collaborative environment to create, explore and share SPARQL queries in Life Sciences 

      Navas-Delgado, Ismael; García-Godoy, Maria Jesús; López-Camacho, Esteban; Aldana-Montes, Jose Francisco (2016)
      Bioqueries provides a collaborative environment to create, explore, execute, clone and share SPARQL queries (including Federated Queries). Federated SPARQL queries can retrieve information from more than one data source.
    • Docking Inter/Intra-Molecular Mediante Metaheurísticas Multi-objetivo 

      López-Camacho, Esteban; García Godoy, María Jesús; García-Nieto, José; Nebro-Urbaneja, Antonio Jesus; Aldana-Montes, Jose Francisco (2015-02-11)
      El Acoplamiento Molecular (Molecular Docking) es un problema de optimización de gran complejidad que consiste en predecir la orientación de dos moléculas: el ligando y el receptor, de manera que formen un complejo molecular ...
    • Enriquecimiento automático de ontologías biomédicas mediante el uso de mappings 

      García Godoy, María Jesús; López-Camacho, Esteban; Roldan-Garcia, Maria del Mar; Aldana-Montes, Jose Francisco (2018-11-15)
      Dione es una representación en OWL del ICD-10-CM, consistente lógicamente, cuyos axiomas definen las inclusiones y exclusiones del ICD-10-CM mediante una metodología basada en los mappings ICD-10-CM/SNOMED-CT, proporcionados ...
    • Estudio de Estrategias de Archivo en PSO Multi-Objetivo para el Docking Molecular 

      López-Camacho, Esteban; García Godoy, María Jesús; García-Nieto, José; Nebro-Urbaneja, Antonio Jesus; Aldana-Montes, Jose Francisco (2016)
      El acoplamiento molecular es un problema de optimización complejo cuyo objetivo es la predicción de la posición de un ligando en el sitio activo de un receptor con la mínima energía de unión. Este problema puede ser formulado ...
    • kpath: An example of metabolic pathway data integration using Linked Data 

      Navas-Delgado, Ismael; García-Godoy, Maria Jesús; López-Camacho, Esteban; Ribinski, Maciej; Reyes-Palomares, Armando; [et al.] (2016)
      The main databases related to metabolic pathways, such as Kegg, Brenda, Reactome and Biocyc, provide partially interlinked data on metabolic pathways. This limitation only allows independent searches to retrieve cross-database ...
    • La enseñanza del metabolismo: retos y oportunidades 

      Medina, Miguel Ángel; Suarez-Marin, Maria Fernanda; Alonso-Carrion, Francisco Jose; Valpuesta-Fernandez, Victoriano; Heredia-Bayona, Antonio; [et al.] (2017-12)
      Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos ...
    • Re-constructing Hidden Semantic Data Models by Querying SPARQL Endpoints 

      García-Godoy, Maria Jesús; López-Camacho, Esteban; Navas-Delgado, Ismael; Aldana-Montes, Jose Francisco (2016-10-24)
      Linked Open Data community is constantly producing new repositories that store information from different domains. The data included in these repositories follow the rules proposed by the W3C community, based on standards ...