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Listar por autor "Ruiz-Sánchez, Antonio Jesús"
Mostrando ítems 1-19 de 19
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A perspective of nanotechnology in hypersensitivity reactions including drug allergy
Montañez-Vega, María Isabel; Ruiz-Sánchez, Antonio Jesús; Perez-Inestrosa, Ezequiel (Lippincott Williams & Wilkins, 2010-08)
Purpose of review We provide an overview of the application of the concepts of nanoscience and nanotechnology as a novel scientific approach to the area of nanomedicine related to the domain of the immune system. Particular ... -
Analytical methodologies for the determination of cisplatin
Espinosa-Bosch, Maria; Ruiz-Sánchez, Antonio Jesús; Sánchez-Rojas, María Fuensanta; Bosch-Ojeda, Catalina
(ScienceDirect, 2008-07-15)
cis-Diamminedichloroplatinum(II) (cisplatin) is a important chemotherapeutic drug for cancer treatment since 1978. Unfortunately, because of the severe side-effects like nephrotoxicity, ototoxicity, etc., they are administered ... -
Cation template assisted oligoethylene glycol desymmetrization by intramolecular Cannizzaro reaction of topologically remote aldehydes.
Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda; Suau Suárez, Rafael; Pérez-de-Inestrosa-Villatoro, Ezequiel
(Elsevier, 2008)
Oligoethylene glycol chains containing 2–5 ethylene glycol units, and possessing a benzyl alcohol and a benzoic acid end groups, can be quantitatively obtained by intramolecular Cannizzaro reaction of the corresponding ... -
Dendrimer-Modified Solid Supports: Nanostructured Materials with Potential Drug Allergy Diagnostic Applications
Ruiz-Sanchez, Antonio Jesus; Montañez-Vega, María Isabel; Nájera-Albendín, Francisco
; Vida-Pol, Yolanda
; Pérez-de-Inestrosa-Villatoro, Ezequiel
(CURRENT MEDICINAL CHEMISTRY, 2012)
Complex functional materials consisting of bioactive molecules immobilized on solid supports present potential applications in biosensoring. Advances in the fabrication of these surface materials are of growing interest ... -
Dendrimeric Antigens. New Approaches Towards Detection of IgE‐Mediated Drug Allergy Reactions
Montañez-Vega, María Isabel; Mayorga, Cristobalina; Torres-Jaén, María Josefa
; Ruiz-Sánchez, Antonio Jesús; Malkoch, M; Hult, A; Blanca, Miguel; Pérez-de-Inestrosa-Villatoro, Ezequiel
[et al.] (RSC Publishing, 2013-05-31)
Drugs are low molecular weight substances which cannot cause an immune response on their own. However, they can act as haptens and form covalent adducts with proteins. The resulting hapten‐carrier (drug‐protein) conjugate ... -
Dendrimers-modified solid supports: towards nanostructures materials for clinical diagnostic
Vida-Pol, Yolanda; Collado-Martín, Daniel
; Nájera-Albendín, Francisco
; Montañe, M I; Pérez-de-Inestrosa-Villatoro, Ezequiel
; Ruiz-Sanchez, Antonio Jesus[et al.] (2013-09-25)
The design and synthesis of new materials for biomedical applications is a high-priority research topic in a number of biomedical areas. The rapid development of nanotechnology over the past few decades has created wide ... -
Design of multi-haptenized dendrimeric-antigens for in vitro IgE recognition
Nájera-Albendín, Francisco; Montañez-Vega, María Isabel
; Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda
; Collado-Martín, Daniel
; Pérez-de-Inestrosa-Villatoro, Ezequiel
; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa
; Blanca Gómez, Miguel[et al.] (2014-06-12)
Reactions mediated by the Immunoglobulin E (IgE) involved a high number of allergic drug responses, ranging from simple skin symptoms to anaphylactic shock.1 In order to emulate the recognition process working in vivo, ... -
Direct characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnose
Ruiz-Sanchez, Antonio Jesus; Collado-Martín, Daniel; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa
; Pérez-de-Inestrosa-Villatoro, Ezequiel
(2020-10-01)
β-lactams are the most widely drug prescribed against infections, but they are the most commonly reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid rejecting them by other ... -
Managing with (fluorescent)-biomimetic dendrimers
Pérez-de-Inestrosa-Villatoro, Ezequiel; Vida-Pol, Yolanda
; Collado-Martín, Daniel
; Nájera-Albendín, Francisco
; Mesa-Antunez, Pablo; Ruiz-Sanchez, Antonio Jesus; Molina, Noemi; Morgado, Anjara[et al.] (2017-06-30)
Dendrimers that are modified through their peripheral groups have been employed for many biomedical purposes. Diagnosis via specific interactions with target proteins is one of the objectives that has been given more ... -
New Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnose
Collado-Martín, Daniel; Pérez-de-Inestrosa-Villatoro, Ezequiel
; Ruiz-Sanchez, Antonio Jesus; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa
(2019-09-11)
Betalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to ... -
Optical Chemical Biosensors for High Throughput Screening of Drugs
Espinosa Bosh, Maria; Ruiz-Sánchez, Antonio Jesús; Sánchez-Rojas, María Fuensanta; Bosch-Ojeda, Catalina
(Bentham Science Publishers Ltd., 2007)
Optical biosensors have been commercially available since the early 1990s, and have been used extensively in many areas of research in the life sciences. Optical biosensors developed for drug analysis generally exploit ... -
Recent Development in Optical Fiber Biosensors
Ruiz-Sanchez, Antonio Jesus; Sánchez-Rojas, María Fuensanta; Bosch-Ojeda, Catalina
; Espinosa-Bosch, Maria (MDPI, 2007)
Remarkable developments can be seen in the field of optical fibre biosensors in the last decade. More sensors for specific analytes have been reported, novel sensing chemistries or transduction principles have been introduced, ... -
Recognition of multiepitope dendrimeric antigens by human immunoglobulin E.
Montañez-Vega, María Isabel; Nájera-Albendín, Francisco
; Mayorga, Cristobalina; Ruiz-Sánchez, Antonio Jesús; Vida-Pol, Yolanda
; Collado-Martín, Daniel
; Blanca, Miguel; Torres-Jaén, María Josefa
; Pérez-de-Inestrosa-Villatoro, Ezequiel
[et al.] (Elsevier, 2015-02-07)
In vitro drug allergy tests have limited sensitivity, partly due to a poor understanding of the immunological recognition of in vitro drug–protein conjugates. We have designed and synthesized multivalent mono- and bi-epitope ... -
Role of minor determinants of amoxicillin in the diagnosis of immediate allergic reactions to amoxicillin.
Background: Skin testing of subjects with immediate hypersensitivity to amoxicillin is performed using major and minor determinants of benzylpenicillin plus amoxicillin. However, sensitivity is not optimal, and other ... -
Sensor electroquímico selectivo hacia BPA en aguas residuales mediante polímeros de impresión molecular sobre óxido de grafeno magnético.
Ruiz-Sánchez, Antonio Jesús; Mena Herrera, Lourdes; Montoro-Leal, Pablo; Jiménez Pérez, Rebeca; Martínez Piernas, Ana B.; Sánchez-Trujillo, Irene; López-Guerrero, María del Mar; Vereda-Alonso, Elisa Isabel
[et al.] (2024)
El bisfenol A (BPA) es un compuesto orgánico ampliamente utilizado en la producción de plásticos y resinas; el cual se libera fácilmente de estos productos y que puede afectar a la salud humana al ser un disruptor endocrino ... -
Spontaneous [2+2] macrocyclization trhough dynamic covalent aminal bonds
Ruiz-Sanchez, Antonio Jesus; Carbajo, Daniel; Nájera-Albendín, Francisco; Alfonso, Ignacio; Pérez-de-Inestrosa-Villatoro, Ezequiel
(2022-06)
Aminals are characterized by the connectivity of two amino groups to the same carbon atom, being the nitrogenated equivalent of acetals. Unlike acetals, aminals have been slightly underexplored in dynamic covalent chemistry ... -
Synthesis and Biomedical aplications of BAPAD: Bisaminoalkylpolyamide Dendrimers
Pérez-de-Inestrosa-Villatoro, Ezequiel; Ruiz-Sanchez, Antonio Jesus; Vida-Pol, Yolanda
; Collado-Martín, Daniel
; Nájera-Albendín, Francisco
; Mesa, Pablo; Morato, Isabel; Barbero, Nekane[et al.] (2014-02-06)
A new class of Dendrimeric Systems (Dendrimers and Dendrons) and the study of their properties in molecular recognition processes are presented. These Dendrimers (BAPAD: BisAminoalkylPolyAmideDendrimers), are designed to ... -
Synthesis of all-aliphatic polyamide dendrimers based on a 3,3′-diaminopivalic acid scaffold.
Ruiz-Sánchez, Antonio Jesús; Mesa-Antúnez, Pablo; Barbero, Nekane; Collado-Martín, Daniel; Vida-Pol, Yolanda
; Nájera-Albendín, Francisco
; Pérez-de-Inestrosa-Villatoro, Ezequiel
[et al.] (RSC publication, 2015-03-09)
Over recent years the importance of dendrimers has continued to increase in both life and material sciences. Multiple chemical strategies have been described toward the preparation of dendrimeric structures. Here, we present ... -
The C-Terminus of H-Ras as a Target for the Covalent Binding of Reactive Compounds Modulating Ras-Dependent Pathways
Oeste, Clara; Díez-Dacal, Beatriz; Bray, Francesca; García de Lacoba, Mario; G de la Torre, Beatriz; Andreu, David; Ruiz-Sánchez, Antonio Jesús; García-Dominguez, Carlota; Rojas, Jose M; Perez-Sala, Dolores[et al.] (PLOS One, 2011-01)
Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their ...