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Listar por autor "Silva, Alcino J."
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Maternal Inflammation Contributes to Brain Overgrowth and Autism- Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells.
Le Belle, Janel E.; Sperry, Jantzen; Ngo, Amy; Ghochani, Yasmin; Laks, Dan R.; López-Aranda, Manuel Francisco; Silva, Alcino J.; Kornblum, Harley I.[et al.] (CellPress, 2014-11-11)A period of mild brain overgrowth with an unknown etiology has been identified as one of the most common phenotypes in autism. Here, we test the hypothesis that maternal inflammation during critical periods of embryonic ... -
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer’s disease and other tauopathies.
Caccamo, Antonella; Magrì, Andrea; Medina, David X.; Wisely, Elena V.; López-Aranda, Manuel Francisco; Silva, Alcino J.; Oddo, Salvatore[et al.] (Wiley-Blackwell, 2013-02-20)Accumulation of tau is a critical event in several neurodegenerative disorders, collectively known as tauopathies, which include Alzheimer's disease and frontotemporal dementia. Pathological tau is hyperphosphorylated and ... -
Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: role of microglia and clinical implications
López-Aranda, Manuel Francisco; Chattopadhyay, Ishanu; Boxx, Gayle M.; Fraley, Elizabeth R.; Silva, Tawnie K.; Zhou, Miou; Phan, Miranda; Herrera, Isaiah; Taloma, Sunrae; Mandanas, Rochelle; Bach, Karen; Gandal, Michael; Geschwind, Daniel H.; Cheng, Genhong; Rzhetsky, Andrey; White, Stephanie A.; Silva, Alcino J.[et al.] (AAAS, 2021-09-17)There is growing evidence that prenatal immune activation contributes to neuropsychiatric disorders. Here, we show that early postnatal immune activation resulted in profound impairments in social behavior, including in ... -
Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene.
López-Aranda, Manuel Francisco; Boxx, Gayle M.; Phan, Miranda; Bach, Karen; Mandanas, Rochelle; Herrera, Isaiah; Taloma, Sunrae; Thadani, Chirag; Lu, Odilia; Bui, Raymond; Liu, Shuhan; Nan, Li; Zhou, Yu; Cheng, Genhong; Silva, Alcino J.[et al.] (Elsevier, 2023-07)BACKGROUND: Tuberous sclerosis complex is a genetic disorder associated with high rates of intellectual disability and autism. Mice with a heterozygous null mutation of the Tsc2 gene (Tsc2+/-) show deficits in hippocampal ... -
Synaptic tagging during memory allocation.
Rogerson, Thomas; Cai, Denise J.; Frank, Adam; Sano, Yoshitake; Shobe, Justin; López-Aranda, Manuel Francisco; Silva, Alcino J.[et al.] (Nature, 2014-02-05)There is now compelling evidence that the allocation of memory to specific neurons (neuronal allocation) and synapses (synaptic allocation) in a neurocircuit is not random and that instead specific mechanisms, such as ...