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A model of increased impulsivity in rats with bilateral parkinsonism treated with Pramipexole
Gago, Belén; Jimenez-Urbieta, Haritz; Marin, Concepció; Quiroga-Varela, Ana; Delgado-Alvarado, Manuel; [et al.] (2016)Impulse control disorders (ICD) is a common side effect of the dopaminergic treatment in patients with Parkinson's disease, which is more associated with dopamine agonists than with levodopa. To understand its pathophysiology, ... -
Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus
Narváez, Manuel; Borroto-Escuela, Dasiel; Millon, Carmelo; Gago, Belén; Flores-Burgess, Antonio; [et al.] (2017-08-30)Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using ... -
Different susceptibility to pramipexole-induced impulsivity in a rat model of parkinson’s disease
Jimenez-Urbieta, Haritz; Merino-Galan, Leire; Rodriguez-Chinchilla, Tatiana; Belloso-Iguerategui, Arantzatzu; Delgado-Alvarado, Manuel; [et al.] (2019-09-12)Impulse Control Disorders (ICD) in patients with Parkinson’s disease are abnormal behaviors caused by long-term use of dopamine agonists, which pathophysiology is poorly understood. Using parkinsonian rats (adeno-associated ... -
Dopamine D4 receptor activation counteracts nigrostriatal pathway activation by morphine: relevance in drug addiction.
Rivera-Ramirez, Alicia; Suárez-Boomgaard, Diana; Gago, Belén; Valderrama-Carvajal, Alejandra; Medina-Luque, José; [et al.] (2013)Morphine induces dopamine release in the caudate putamen (CPu), which promotes stereotyped behavior and habit learning for drug-seeking and –taking. Nigrostriatal pathway stimulation by morphine is due to a removal of tonic ... -
The dopaminergic mesolimbic system are involved in the anhedonic-like effects produced by galanin (1-15) in rats.
Cantero-García, Noelia; García-Durán, Laura; Gago, Belén; Flores-Burgess, Antonio; Alén, Francisco; [et al.] (2019-09-10)Galanin (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in several behavioural tests. Recently, we described that GAL(1-15) induces an anhedonic-like effect in saccharine self-administration and sucrose ... -
The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
Millón, Carmelo; Flores-Burgess, Antonio; Gago, Belén; García-Durán, Laura; Cantero-García, Noelia; [et al.] (2019-11-18)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a ... -
Effects of galanin n-terminal fragment (1-15) in sac- charin self-administration and sucrose preference test in rats.
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago, Belén; Allén, Francisco; [et al.] (2019-09-12)The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions in several behavioral tests, and these effects were significantly stronger than the ones induced by Galanin (1-29). Since, ... -
Effects of Galanin N-Terminal fragment (1-15) in the anhedonic behavioural tests in rats.
Garcia-Cantero, Noelia; Flores-Burgess, Antonio; Gago, Belén; García-Durán, Laura; Alén, Francisco; [et al.] (2021-01-22)The Galanin N-terminal fragment (1-15)[GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioural tests in rats. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in ... -
Galanin (1-15) enhancement of the behavioral effects of a 5-HT1AR agonist and fluoxetine in the forced swimming test gives a new therapeutic strategy against depression: possible role of GALR1-GALR2-5-HT1AR heteroreceptor complexes
Flores-Burgess, Antonio; Millon, Carmelo; Puigcerver-Martinez, Araceli; Gago, Belén; García-Durán, Laura; [et al.] (2019-06-17)Major Depression is the most frequent mood disorder, with a lifetime prevalence that has been reported to range from 7% to 21%. It is associated with a substantial functional impairment, diminished quality of life, increased ... -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millón, Carmelo; Gago, Belén; Narváez, Manuel; Borroto-Escuela, Dasiel O.; [et al.] (2017)The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ... -
Galanin (1-15) enhances the behavioural effects of escitalopram in the forced swimming test in rats
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago, Belén; Puigcerver, Araceli; [et al.] (2021-01-22)The selective serotonergic reuptake inhibitors (SSRIs) are the most commonly used for the treatment of major depression. Recently, we observed that the Galanin N-terminal fragment (1-15) [GAL(1-15)] enhances the ... -
Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment
Narváez, Manuel; Borroto-Escuela, Dasiel; Millón, Carmelo; Flores-Burgess, Antonio; Gago, Belén; [et al.] (2015-10-05)We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin interacts with Neuropeptide Y Y1 receptor in the dentate gyrus of the hippocampus through GALR2/NPYY1R heterodimers
Narváez, Manuel; Borroto-Escuela, Dasiel; Millón, Carmelo; Flores-Burgess, Antonio; Gago, Belén; [et al.] (2016-07-11)We have shown Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to analyze GAL/NPYY1R interactions ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millón, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, Estela; Gago, Belén; Serrano, Antonia; [et al.] (2018-06-28)Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Galanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.
Millón, Carmelo; Flores-Burgess, Antonio; Narváez, Manuel; Borroto-Escuela, Dasiel; Santín, Luís; [et al.] (2016-07-27)Galanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In ... -
Galanin n-terminal gragment (1-15) modifies the 5-HT1A receptor against [H3]-8-OH-DPAT binding in the dorsal raphe and hippocampus of the rat
Flores-Burgess, Antonio; Millón, Carmelo; Narváez, Manuel; Barroto-Escuela, Dasiel; Santín, Luis; [et al.] (2016-09-09)We have described that Galanin N-terminal fragment (1-15) [GAL(1-15)] is associated with depressive effects and also modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist 8-OH-DPAT. The aim ... -
Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment
Narváez, Manuel; Borroto-Escuela, Dasiel; Millón, Carmelo; Flores-Burgess, Antonio; Gago, Belén; [et al.] (2015-10-05)We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin(1-15) reverses the impaired long-term memory effect of fluoxetine in the novel object recognition test. Role of 5-HT1A receptor in medial prefrontal cortex
Flores-Burgess, Antonio; Millón, Carmelo; Gago, Belén; García-Durán, Laura; Cantero-García, Noelia; [et al.] (2019-12-16)In this work, we have studied the effects of GAL(1-15) on FLX- mediated effects on the NOR and the OLM, two tasks where FLX treatment impaired long-term memories 24h post-training. Since the mPFC is a core region for the ... -
GALR2/NPYY1R heterodimers interact at receptor level in the dentate gyrus of the hippocampus in rats
Narváez, Manuel; Borroto-Escuela, Dasiel; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago, Belén; [et al.] (2016-09-26)Previously, we have described Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to study GAL/NPYY1R ... -
Increased Impulsivity following progressive nigral degenereation and chronic pramipexole treatment in an animal model of Parkinson's disease
Jimenez-Urbieta, Haritz; Merino-Galan, Leire; Rodríguez-Chichilla, Tatiana; Delgado-Alvarado, Manuel; Quiroga-Varela, Ana; [et al.] (2017-10-02)Dopamine agonists (DA) that are widely used to treat motor deficits in patients with Parkinson’s disease (PD) are frequently associated with the development of abnormal-impulsive behaviors (AIB). The pathophysiology ...