Listar por autor "López-Salas, Alexander"
Mostrando ítems 1-7 de 7
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Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion
Díaz-Sánchez, Estela; López-Salas, Alexander; Mirchandani-Duque, Marina; Álvarez-Contino, José Erik; Sánchez-Pérez, José Andrés; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia
; Narváez-Peláez, Manuel[et al.] (Elsevier, 2023)
Different brain regions’ interactions have been implicated in relevant neurological diseases, such as major depressive disorder (MDD), anxiety disorders, age-dependent cognitive decline, Alzheimer’s disease (AD) and addiction. ... -
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions.
Sánchez-Varo, Raquel María; López-Salas, Alexander; Rasiel, Beltran-Casanueva; Díaz-Sánchez, Estela; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (Springer Nature, 2024-03-28)
Background: Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This ... -
Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations
Narváez-Peláez, Manuel; Andrade-Talavera, Yuniesky; Fores-Pons, Ramón; Valladolid-Acebes, Ismael; Siegele, Pia; Hernández-Sosa, Alejandro; Fisahn, Andre; López-Salas, Alexander; Borroto Escuela, Dasiel Óscar[et al.] (2021-11-04)
The majority of the fibroblast growth factor receptor 1-serotonin 1 A receptor (FGFR1-5-HT1AR) heterocomplexes in the hippocampus appeared to be located mainly in the neuronal networks and a relevant target for antidepressant ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus with Consequent Augmented Spatial Memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (IOAP-MPDI, 2022-06-01)
Dysregulation of hippocampal neurogenesis is linked to several neurodegenereative diseases, where boosting hippocampal neurogenesis in these patients emerges as a potential therapeutic approach. Accumulating evidence for ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (2022-09-22)
Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses ... -
Galanin and neuropeptide Y interactions linked to neuronal precursor cells of the dentate gyrus in the hippocampus. Role in depression and cognitive impairment.
Fores-Pons, Ramón; Borroto Escuela, Dasiel Óscar; Pita-Rodríguez, Mariana; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Rosas-Marqués, Paloma; Zamorano-González, Pablo; Fuxe, Kjell; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2021-11-05)
Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Unveiling the Synergistic Interplay of Neuropeptides for Novel Therapeutic Approaches in Neurodegenerative and Depressive Disorders.
Díaz-Sánchez, Estela; López-Salas, Alexander; Álvarez-Contino, José Erik; Barbancho-Fernández, Miguel Ángel; Sánchez-Pérez, José Andrés; Blanco-Reina, Encarnación; Brito Rodríguez, Ismel; Serrano-Castro, Pedro Jesús; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2023)
The intricate relationship between hippocampal neurogenesis dysregulation and neurodegenerative diseases such as Alzheimer's, as well as depression, has sparked an urgent call for innovative therapeutic strategies. Our ...