Listar por autor "Muñoz-Castro, Clara"
Mostrando ítems 1-12 de 12
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Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.
Sanchez-Mico, Maria Virtudes; Jiménez, Sebastián; Gómez-Arboledas, Ángela; Muñoz-Castro, Clara; Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Mejías, Elisabeth
; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Galea, Elena; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Wiley, 2020-12-07)
Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques in Alzheimer's disease (AD). We have previously shown that reactive astrocytes enwrap, phagocytose, ... -
An intragenic duplication within SIRPβ1 shows a dual effect over Alzheimer’s disease cognitive decline altering the microglial response.
García-Alberca, JM; de Rojas, I; Sánchez-Mejías, Elisabeth; Garrido-Martín, D; Gonzalez-Palma, L; Jimenez, S; Pino-Angeles, A; Cruz-Gamero, JM; Mendoza, S; Alarcón-Martín, E; Muñoz-Castro, Clara; Real-Navarrete, Luis Miguel; Tena, Juan J.; Polvillo, R; Govantes, F; Lopez, A; Royo-Aguado, JL; Navarro, V; Gonzalez, I; Ruiz, M; Reyes-Engel, Armando; Gris, E; Bravo, MJ; Lopez-Gutierrez, L; Mejías-Ortega, Marina; De la Guía, María Paz; López de la Rica, M; Ocejo, Olga; Torrecilla, J; Zafra, C; Nieto, MD; Urbano, C; Jiménez-Sánchez, R; Pareja, N; Luque, M; García-Peralta, María; Carrillejo, Rosario; Furniet, MDC; Rueda, L; Sánchez-Fernández, A; Mancilla, T; Peña, I; García-Casares, N; Moreno-Grau, S; Hernández, I; Montrreal, L; Quintela, I; González-Pérez, A; Calero, M; Franco-Macías, Emilio; Macías, J; Menéndez-González, M; Frank-García, A; Huerto Vilas, R; Diez-Fairen, M; Lage, C; García-Madrona, S; García-González, P; Valero, S; Sotolongo-Grau, O; Pérez-Cordón, A; Rábano, A; Arias Pastor, A; Pastor, AB; Espinosa, A; Corma-Gómez, A; Martín Montes, A; Sanabria, A; Martínez Rodríguez, C; Buiza-Rueda, D; Rodriguez-Rodriguez, E; Ortega, G; Alvarez, I; Rosas Allende, I; Pineda, JA; Rosende-Roca, M; Bernal Sánchez-Arjona, M; Fernández-Fuertes, M; Alegret, M; Roberto, N; Del Ser, T; Garcia-Ribas, G; Sánchez-Juan, P; Pastor, P; Piñol-Ripoll, G; Bullido, MJ; Álvarez, V; Mir, P; Medina, M; Marquié, M; Sáez, ME; Carracedo, A; Laplana, M; Tomas-Gallardo, L; Orellana, A; Tárraga, LL; Boada, M; Fibla Palazon, J; Vitorica Ferrández, Javier; Ruiz, A; Guigo, R; Gutiérrez-Pérez, Antonia; Royo-Sánchez-Palencia, José Luis[et al.] (SAGE, 2024)
Microglia play an important role in the maintenance of brain homeostasis, and microglial dysfunction plays a causative role in Alzheimer disease pathogenesis. Here we focus on the signal regulatory protein SIRPβ1, a surface ... -
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology.
Romero-Molina, Carmen; Navarro, Victoria; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Fernández-Valenzuela, Juan José; Sanchez-Mico, Maria Virtudes; Muñoz-Castro, Clara; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier; Vizuete, Marisa[et al.] (Frontiers, 2018-11-14)
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer's disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology ... -
Diversity of plaque-associated myeloid cells subtypes in human alzheimer’s disease brain
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Aims: Parenchymal microglia, as well other myeloid cells, have been postulated as a critical factor in Alzheimer´s disease (AD) pathogenesis since the identification of genetic risk factors related to their functions. ... -
Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.
Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jimenez, Sebastian; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Springer Nature, 2020-09-08)
In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation ... -
Involvement of different aβ-associated myeloid populations in the human alzheimer’s brain
Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Muñoz-Castro, Clara; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2022)
Parenchymal microglia, the brain-resident immune cells, have been postulated as a critical factor in Alzheimer´s disease (AD) since the identification of genetic risk factors related to their functions. Though the role of ... -
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Navarro-Garrido, Victoria; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Muñoz-Castro, Clara; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Frontiers, 2018-05)
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ... -
Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Muñoz-Castro, Clara; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2018-07-20)
Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
Sánchez-Varo, Raquel María; Fernández-Valenzuela, Juan José; Muñoz-Castro, Clara; De Castro Carratalá, Vanessa; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Núñez-Díaz, Cristina; Gómez-Arboledas, Ángela; Moreno-González, Inés; Moyano, F; Vizuete, María Luisa; Dávila-Cansino, José Carlos; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (Alzheimer disease & Parkinson disease Conference 2021, 2021)
Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Monocyte-derived cells invade amyloid plaques in human alzheimer’s disease hippocampus.
Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica Ferrández, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Peripheral myeloid cells infiltrate the hippocampus of Alzheimer's disease patients.
Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ...