Listar por autor "Alonso-Carrión, Francisco José"
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Antioxidant responses related to temozolomide resistance in glioblastoma
Campos-Sandoval, Jose Angel
; Gómez-García, María C.; Santos-Jiménez, Juan de los; Mates-Sanchez, Jose Manuel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier[et al.] (Elsevier, 2021)
Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ... -
Aprendizaje colaborativo y el modelo de clase invertida como ayuda para el aprendizaje del metabolismo
Alonso-Carrión, Francisco José (2018-11-09)
Lo siguiente resume el contenido de la presentación oral que será expuesta en este Congreso dedicada a describir la base de las metodologías de aprendizaje colaborativo (AC) y de inversión de la clase (flipped learning) ... -
Changes in the nuclear proteomic profiling of human glioblastoma cells after glutaminase overexpression
Márquez-Gómez, Javier; Cardona, Carolina; Alonso-Carrión, Francisco José; Lobo, Carolina; Campos-Sandoval, Jose Angel; Martín Rufián, Mercedes[et al.] (2013)
Human glutaminase (GA) enzymes are the products of two genes, GLS and GLS2. GA isozymes play markedly different roles in tumour biology: GLS isoforms (KGA and GAC) are related to cell growth and proliferation, whereas GLS2 ... -
Design and generation of a glutaminase GLS2 conditional knockout mice
Peñalver, Ana; Tosina, Marta; Martín-Rufián, Mercedes; Campos-Sandoval, Jose Angel; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sanchez, Jose Manuel; Ramírez, Miguel Ángel; Gutiérrez-Adán, Alfonso; Márquez-Gómez, Javier[et al.] (2014-10-04)
Mammalian glutaminase (GA; EC 3.5.1.2) is the main enzyme involved in brain generation of glutamate (Glu). This amino acid acts as an excitatory neurotransmitter within the CNS, and it is also implicated in behavioral ... -
Generación y caracterización de modelos murinos transgénicos para el análisis de glutaminasas cerebrales
(UMA Editorial, 2016)El estudio de modelos murinos transgénicos deficientes para un determinado gen (knockout, KO) es una de las principales herramientas que permite elucidar la función génica. Con el objetivo de modificar secuencias endógenas, ... -
Glutaminasa GLS2 en cerebro y cáncer: nuevas localizaciones celulares e identificación de proteínas interactivas mediante aproximaciones neuroquímicas y proteómicas
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)En este trabajo se resumen importantes nuevas funciones asociadas a la expresión de isoenzimas glutaminasa (GA; EC 3.5.1.2), tanto en cerebro como en células cancerosas, con especial énfasis en las isoenzimas Gls2. En ... -
La enseñanza del metabolismo: retos y oportunidades
Medina, Miguel Ángel; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José; Valpuesta-Fernandez, Victoriano; Heredia-Bayona, Antonio; Salto-González, Rafael; Vílchez-Rienda, José Dámaso; Girón González, María Dolores; Morata-Losa, Maria Pilar; Urdiales-Ruiz, Jose Luis; Fajardo-Paredes, Ignacio José; García Ponce, Ángel Luis; Torres, Néstor; Santos, Guido; Herráez, Ángel; Roca-Salom, Pilar; Sastre-Serra, Jorge; Oliver, Jordi; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Navas-Delgado, Ismael; García-Godoy, Maria Jesús; López-Camacho, Esteban; Rybinski, Maciej; Aldana-Montes, José Francisco; Rodrígue-Caso, Carlos; Perez-Rodriguez, Josefa; Blanco-Lopez, Angel[et al.] (2017-12)
Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos ... -
Learning contract, co-operative and flipped learning as useful tools for studying metabolism
Martinez-Poveda, Beatriz Amparo; García Ponce, Ángel Luis; Blanco-Lopez, Angel; Rodriguez-Quesada, Ana Maria; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José; Medina, Miguel Ángel[et al.] (2018-06-25)
Undergraduate students in Biology identify Metabolic Biochemistry as a particularly difficult subject. This is due to the fact that students need to interconnect properly all the contents of its syllabus throughout their ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
de los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, Jose Angel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sanchez, Jose Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus
García-Bonilla, María; Shumilov, Kirill; Peñalver, Ana; Castilla, Laura; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutierrez-Perez, Antonia; Jimenez-Lara, Antonio Jesus[et al.] (2016-07-11)
Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative ... -
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation
García-Ponce, Ángel Luis; Martinez-Poveda, Beatriz Amparo; Blanco-Lopez, Angel; Rodriguez-Quesada, Ana Maria; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José; Medina, Miguel Ángel[et al.] (2020-09-23)
Metabolism and its regulation is one of the most complex and difficult topics for students learning biochemistry. A problem-/case-based learning (PBL) approach can be useful to help biochemistry students to fulfill the ... -
Ratones knock-out del receptor lpa1 de ácido lisofosfatídico presentan un acusado déficit de la isoenzima glutaminasa KGA (GLS) y una morfología alterada en las espinas dendríticas de hipocampo y corteza
Peñalver, Ana; Campos-Sandoval, Jose Angel; Sanchez-Varo, Raquel Maria; Cardona, Carolina; Castilla, Laura; Blanco, Eduardo; Martín-Rufián, Mercedes; Segura-Checa, Juan Antonio; Mates-Sanchez, Jose Manuel; Alonso-Carrión, Francisco José; Gutierrez-Perez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (2015-09-25)
Objectives: The objective of the present study was to utilize mice with knocked-down lysophosphatidic acid 1 (LPA1) receptor to ascertain changes in glutamatergic transmission that may help to explain part of the cognitive ... -
Regulación Transcripciones del Gen GLS2 y Obtención de Células Madre Embrionarias Transformadas para Generación de Ratones Knockout
(Servicio de Publicaciones y Divulgación Científica, 2016)La enzima glutaminasa activada por fosfato (GA) cataliza la hidrólisis del grupo amido de la glutamina (Gln) para rendir glutamato (Glu) y amonio. Esta enzima es esencial para el ciclo Gln-Glu entre neuronas y astrocitos ... -
Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles
Medina, Miguel Ángel; García-Ponce, Ángel Luis; Blanco-Lopez, Angel; Rodriguez-Quesada, Ana Maria; Urdiales-Ruiz, Jose Luis; Fajardo-Paredes, Ignacio José; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José[et al.] (ACS, 2022-05-25)
Metabolism is a challenging subject for bioscience students due to the intrinsic complexity of the metabolic network, as well as that of the overlapping mechanisms of metabolic regulation. Collaborative learning based on ...