Listar por autor "Peñalver, Ana"
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Design and generation of a glutaminase GLS2 conditional knockout mice
Peñalver, Ana; Tosina, Marta; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel
; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Ramírez, Miguel Ángel; Gutiérrez-Adán, Alfonso; Márquez-Gómez, Javier[et al.] (2014-10-04)
Mammalian glutaminase (GA; EC 3.5.1.2) is the main enzyme involved in brain generation of glutamate (Glu). This amino acid acts as an excitatory neurotransmitter within the CNS, and it is also implicated in behavioral ... -
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
López de la Oliva, Amada; Campos-Sandoval, José A.; Gómez-García, María Carmen; Cardona, Carolina; Martín-Rufián, Mercedes; Sialana, Fernando J.; Castilla, Laura; Bae, Narkhyun; Lobo, Carolina; Peñalver, Ana; García-Frutos, Marina; Carro, David; Enrique, Victoria; Paz-Gutiérrez, José Carlos; Mirmira, Raghavendra G.; Gutiérrez, Antonia; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Lubec, Gert; Márquez-Gómez, Javier[et al.] (Nature Portfolio, 2020-02-10)
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently ... -
Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus
García-Bonilla, María; Shumilov, Kirill; Peñalver, Ana; Castilla, Laura; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús[et al.] (2016-07-11)
Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative ... -
Ratones knock-out del receptor lpa1 de ácido lisofosfatídico presentan un acusado déficit de la isoenzima glutaminasa KGA (GLS) y una morfología alterada en las espinas dendríticas de hipocampo y corteza
Peñalver, Ana; Campos-Sandoval, José Ángel; Sánchez-Varo, Raquel María; Cardona Ramírez, Carolina; Castilla, Laura; Blanco, Eduardo; Martín-Rufián, Mercedes; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (2015-09-25)
Objectives: The objective of the present study was to utilize mice with knocked-down lysophosphatidic acid 1 (LPA1) receptor to ascertain changes in glutamatergic transmission that may help to explain part of the cognitive ...